April 3, 3:30 PM – 4:30 PM
From molecular condensation to protein sorting
Engineered nuclear import receptor karyopherin-β2 chaperones aberrant phase transitions of disease-associated cargo
Charlotte M. Fare, University of Pennsylvania
Proteasome localization is regulated through mitochondrial respiration and kinase signaling
Kenrick A. Waite, University of Kansas Medical Center
Interplay between TPR nucleoporin and TREX-2 complex in mRNA export
Mary Dasso, National Institute of Child Health and Human Development
Structure of a pathologic amyloid nucleus determined by rational genetic deconstruction of an intracellular nucleation barrier
Randal Halfmann, Stowers Institute for Medical Research

April 3, 3:30 PM – 4:30 PM
Membrane and membrane-free organelles and quality control
Client specificity of an ATP-independent chaperone is regulated by a temperature sensitive switch
Alex Siegel, California Institute of Technology
Self-assembling long coiled-coil proteins driving the formation of a nanoscale cylindrical architecture at human centrosomes
Jong il Ahn, National Cancer Institute
Identification of signaling pathways and phase separating domains that drive cajal body formation
Madelyn Kaye Logan, University of Mississippi Medical Center
Investigating mitochondrial dysfunction in Barth syndrome
Olivia L. Sniezek, Johns Hopkins School of Medicine

April 3, 3:30 PM – 4:30 PM
Atypical signaling
Unconventional GPCR-PKA signaling in the hedgehog pathway
Benjamin Myers, University of Utah School of Medicine
First-in-class deubiquitylase inhibitors reveal new enzyme conformations
Francesca Chandler, University of Leeds
Non-canonical recruitment of PKA catalytic subunits to RIα-driven biomolecular condensates
Julia C. Hardy, University of California, San Diego
The plastoglobule-localized AtABC1K6 is a Mn2+-dependent protein kinase necessary for timely transition to reproductive growth
Peter K Lundquist, Michigan State University

April 3, 4:45 PM – 5:45 PM
RNA: processing, transport and regulatory mechanisms
Detecting RNA dynamics in live mammalian cells with fluorescence lifetime-based sensors
Esther Braselmann, Georgetown University
Divalent cation driven liquid-liquid phase separation of disordered acidic proteins
Joshua E. Mayfield, University of California, San Diego
The effects of tail truncations of pre-messenger RNA splicing protein Dib1
Virginia McGrath, Trinity University
Imaging mRNAs with corrected RNA stability
Weihan Li, Albert Einstein College of Medicine

April 3, 4:45 PM – 5:45 PM
New innovations in “omic” technology
A meta-transcriptomic analysis of complicated diverticulitis tissue: The role of xenobiotics in the gut
Brittney Nichole McMullen, Juniata College
Targeted metabolomics reveals plasma biomarkers and metabolic alterations of the aging process in healthy young and older adults
Jeffrey Patterson, Arizona State University
Evidence for widespread cytoplasmic structuring into mesoscopic condensates
Martin Wühr, Princeton University
Lipidomics identifies novel circulating markers of CVD risk in African American and Caucasian women
Paula Gonzalez, University of Wisconsin–Madison

April 4, 9:15 AM – 11:15 AM
Phase transitions of structured complexes and cellular machinery
Building the microtubule cytoskeleton via phase transitions
Sabine Petry, Princeton University
Selective transport in the nuclear pore complex
David Cowburn, Albert Einstein College of Medicine
Understanding how oncogenic fusion proteins drive aberrant gene expression through phase separation
Richard Kriwacki, St. Jude Children’s Research Hospital
Decoding plasticity of the dark proteome
Edward Lemke, Johannes Gutenberg University; Institute of Molecular Biology