Loading Events
  • This event has passed.

Biochemistry Seminar: Richard W. Kriwacki, “Phase Separation in Biology and Disease”

Event Date October 24, 2018
8:00 am - 5:00 pm - EDT
Website http://forum.sci.ccny.cuny.edu/administration/chemistry/events/archives/2018/10/biochemistry-seminar-richard-w.-kriwacki-tba
Organizers Science Division Forum
Venue CUNY Advanced Science Research Center
85 St Nicholas Terrace
New York, NY 10031 United States

+ Google Map
Richard W. Kriwacki, Associate Member
Department of Structural Biology
St. Jude Graduate School of Biomedical Science
St. Jude Children’s Research Hospital, TN, USA



Phase separation mediates formation of various membraneless organelles, as well as assembly of other cellular structures that control diverse biological processes, including membrane receptor signaling, endocytosis, stress sensing, and both activation and silencing of gene transcription. Phase separation organizes chemically diverse biopolymers, including proteins, nucleic acids, and lipids, to perform complex biochemical and mechanical processes. Consequently, alteration of the process of phase separation, yielding aberrant molecular organization and condensed phases with atypical material properties, is associated with a range of human diseases such as neurodegeneration and cancer. For example, the properties of the nucleolus, the largest membraneless organelle in human cells and a center for ribosome biogenesis and stress signaling, are altered through different mechanisms in ALS and certain cancers. Further, regulation of gene expression, hypothesized to be controlled through condensation of genes, transcription factors and RNA polymerase II, may be altered by phase separation-prone oncoproteins in certain leukemias. We will discuss our efforts to understand how phase separation contributes to biological processes in normal cells and how these processes are altered in disease, including neurodegeneration and cancer.