Cells across the tree of life react to sudden increases in temperature—heat shock—in consistent ways. Proteins and mRNAs aggregate, most protein synthesis halts, and mRNAs encoding chaperones, long known as the protein-misfolding rescue crew, are massively expressed and selectively translated. But what looks like a cell-melting thermal catastrophe may be something else entirely: a series of adaptive condensation responses. I’ll discuss how condensation helps cells sense changes in temperature, how condensation redirects translation, and how chaperones act as condensation regulators.

Talk by:
D. Allan Drummond
University of Chicago

Start time in various timezones:
7:00 am PDT
9:00 am CDT
10:00 am EDT
2:00 pm UTC
3:00 pm CET
*Please note the time differences due to the end of daylight saving time in Europe

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