Loading Events
  • This event has passed.

Emma Lundberg on Mapping the Spatiotemporal Proteome Architecture of Human Cells

Event Date June 1
Time
10:00 am - 11:00 am - EDT
Tags
Organizers Dewpoint Condensates.com
Location Online

Biological systems are functionally defined by the nature, amount, and spatial location of the totality of their proteins. We have generated an image-based map of the subcellular distribution of the human proteome and showed that there is great complexity to the subcellular organization of the cell. As much as half of all proteins localize to multiple compartments, giving rise to potential pleiotropic effects, and around 20% of the human proteome shows spatiotemporal variability. Our temporal mapping results show that cell cycle progression explains less than half of all temporal protein variability, and that most cycling proteins are regulated post-translationally, rather than by transcriptomic cycling. This work is critically dependent on computational image analysis, and I will discuss machine learning approaches for classification of spatial subcellular patterns and how such embeddings can be used to build a multi-scale model of cell architecture. In summary, I will demonstrate the importance of spatial proteomics data for improved single cell biology and present how the freely available Human Protein Atlas database (www.proteinatlas.org) can be used as a resource for life science.

Talk by:
Emma Lundberg
Stanford University

Start time in various timezones:
7:00 am PDT
9:00 am CDT
10:00 am EDT
2:00 pm UTC
3:00 pm BST
4:00 pm CEST

Note, this event has passed, but we’ve got you covered:
See the video here

Create an Account or Sign In to register for the talk.