I will be talking about how nuclear bodies form on specific sites on chromatin and how they relate to transcription of specific sets of genes. A major idea in the nucleus is that these biomolecular condensates form on nascent RNA tethered to these long DNA polymers. This enables specificity of composition, structure, and function for each nuclear body. We have been focused on Cajal bodies and related other bodies, such as histone locus bodies. I will discuss our evidence for RNA involvement in Cajal body formation as well as unpublished work on the protein composition of Cajal bodies. This work has revealed potential roles for a novel set of proteins in regulating the chromatin association of Cajal bodies. I will also discuss our recent insights into the substructure of Cajal bodies and the role of SMN tudor domain binding to proteins modified by dimethylarginine (DMA). I will discuss the potential for DMA-tudor interactions to create an interface between functionally different subdomains of the Cajal body and specular on other roles DMA-tudor interactions may play in cellular organization.

Talk by:
Karla Neugebauer
Yale University

Start time in various timezones:
7:00 am PDT
9:00 am CDT
10:00 am EDT
2:00 pm UTC
3:00 pm BST
4:00 pm CEST

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