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LMB Seminar: Biomolecular condensates and their implications for physiology and disease

Event Date October 19, 2021
11:00 am - 12:00 pm - BST
Website https://www2.mrc-lmb.cam.ac.uk/news-and-events/scientific-seminars/
Organizers MRC Laboratory of Molecular Biology, Cambridge
Location Online

Speaker: Tony Hyman, Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany
Host: Andrew Carter

Cells organize many of their biochemical reactions by formation and dissolution of non-membrane-bound compartments. Recent experiments show that one common mechanism for such biochemical organization is phase separation of disordered proteins to form liquid-like compartments. These compartments can subsequently harden to form compartments with new material properties such as gels and glasses. These compartments can be described by principles elucidated from condensed-matter physics and are therefore termed biomolecular condensates. I will discuss potential roles of phase separation in organization and robustness of cellular biochemistry and the role of aberrant phase separation in disease.