|Event Date||October 19, 2021|
11:00 am - 12:00 pm - BST
|Organizers||MRC Laboratory of Molecular Biology, Cambridge|
Speaker: Tony Hyman, Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany
Host: Andrew Carter
Cells organize many of their biochemical reactions by formation and dissolution of non-membrane-bound compartments. Recent experiments show that one common mechanism for such biochemical organization is phase separation of disordered proteins to form liquid-like compartments. These compartments can subsequently harden to form compartments with new material properties such as gels and glasses. These compartments can be described by principles elucidated from condensed-matter physics and are therefore termed biomolecular condensates. I will discuss potential roles of phase separation in organization and robustness of cellular biochemistry and the role of aberrant phase separation in disease.