An informal one day meeting organised by Astra Zeneca, MRC LMB and Imperial College London examining the application of cutting edge biophysical techniques in complex biological settings. Bringing together scientists in both academia and industry for stimulating talks and discussions how these new and emerging technologies may be able to address challenging questions in the future.

 

11.00-12.25:               Session I:  Imaging Across Scales

Sir Mene Pangalos, EVP Biopharmaceuticals R&D, AstraZeneca

Opening remarks

Andrew Carter.  MRC Laboratory of Molecular Biology, UK.

Shulin: a novel factor packaging axonemal outer dynein arms for ciliary targeting

Julia Mahamid.  EMBL Heidelberg, Germany.

Molecular view into cellular functions by in-cell cryo-electron tomography

Richard Goodwin.  Drug Discovery AstraZeneca, UK.

Integrated molecular imaging–technologies with the power to offer a new view on the tissue microenvironment and map the efficacy and safety of new therapies

12.25-13.00:   ‘Lunch’

13.00-14.15:               Session II:  Theory and Simulation

Philip Biggin.  Dept. Biochemistry, University of Oxford, UK.

Computational biophysics of trafficking receptors

Martin Depken.  TU Delft, Netherlands.

Using mechanistic modelling to improve off-target activity predictions and elucidate the physical basis of SpCas9 fidelity

Jean-Philip Piquemal.  Dept. Chemistry, Sorbonne University, France.

TBC

14.15-14.30:    Break

14.30-15.45:                Session III:  Biological Phase Separation

Evan Sprujit.  Radboud University, Netherlands.

Understanding biological phase transitions with minimal peptide-based models

Priya Banerjee.  Dept. Physics. University at Buffalo, USA.

Emergent structure and dynamics of protein-RNA condensates

Stephanie Weber.  Dept. Biology, McGill University, Canada.

No membrane, no problem: condensing bacterial organelles

15.45-16.00:    Break

16.00-17.00                Keynote Lecture

Petra Schwille.  Director, Max Plank Institute for Biochemistry, Martinsried, Germany

Is there a minimal set of functions for life?

TBC

Closing remarks