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Santa Fe Institute: Phase Separation and the Formation of Cellular Bodies

Event Date August 11, 2019
12:15 pm - 1:15 pm - UTC-7
Website https://www.santafe.edu/events/phase-separation-and-the-formation-of-cellula
Organizers Santa Fe Institute
Venue Santa Fe Institute
1399 Hyde Park Rd
Santa Fe, NM 87501 United States

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Collins Conference Room

Bin Xu (Princeton University)

Abstract.  Cellular bodies in eukaryotic cells spontaneously assemble to form cellular compartments. Among other functions, these bodies carry out essential biochemical reactions. Cellular bodies form micron-sized structures, which, unlike canonical cell organelles, are not surrounded by membranes. A recent in vitro experiment has shown that phase separation of polymers in solution can explain the formation of cellular bodies. We constructed a lattice-polymer model to capture the essential mechanism leading to this phase separation. We used both analytical and numerical tools to predict the phase diagram of a system of two interacting polymers, including the concentration of each polymer type in the condensed and dilute phase.


SFI Host: SaJennifer Dunne
Purpose: Research Collaboration