Postdoc position available to study the modular architecture of IDRs

University of Texas Southwestern Medical Center (UTSW)

Postdoctoral position to study the architecture and function of intrinsically disordered proteins.

The laboratory of Matthew Parker in the Department of Biophysics at UT Southwestern Medical Center has multiple postdoctoral positions available for researchers of diverse technical and educational backgrounds. The Parker Laboratory studies the molecular mechanisms of DNA replication initiation (Adiji et al. 2024) and the architecture and function of protein intrinsically disordered regions. We have recently developed a new bioinformatic approach to quantify linear variance in amino acid composition revealing a hitherto unappreciated level of logic and interpretability in protein disordered regions (McConnell and Parker 2023). These studies demonstrate that disordered sequences are non-randomly organized into modular architectures and we seek individuals interested in understanding how this novel sequence-spanning level of organization impacts protein disordered region function and conformation in vitro and in vivo. The Parker Laboratory implements a multidisciplinary approach that spans bioinformatics, reconstitution biochemistry, live cell fluorescence imaging, and genetics, and we are interested in recruiting highly ambitious individuals with the ability to think and work independently.

Candidates must hold a Ph.D. and/or M.D. degree and must have an established record of research productivity as evidenced by peer-reviewed publications.

Information on the UT Southwestern Medical Center postdoctoral training program and benefits can be found in our Postdoc Handbook or at

Interested individuals should send a cover letter explaining their interest in the lab, a CV and a list of three references to

Matthew Parker, Ph.D.
UT Southwestern Medical Center
5323 Harry Hines Blvd.
Dallas, Texas 75390-8816


UT Southwestern Medical Center is committed to an educational and working environment that provides equal opportunity to all members of the University community. In accordance with federal and state law, the University prohibits unlawful discrimination, including harassment, on the basis of: race; color; religion; national origin; sex; including sexual harassment; age; disability; genetic information; citizenship status; and protected veteran status. In addition, it is UT Southwestern policy to prohibit discrimination on the basis of sexual orientation, gender identity, or gender expression.



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