Postdoctoral Associate – Disney Lab

Beginning June 1, 2020, the Disney group in the Department of Chemistry at The Scripps Research Institute (disneylaboratory.org) is seeking to hire multiple Postdoctoral Fellows in RNA Chemical Biology.

Scripps Research, one of the largest private non-profit biomedical research institutes in the world, comprises two linked campuses in Florida and California. New Fellows will conduct studies in drug discovery & development alongside over 200 internationally renowned faculty, contributing to Scripps’ reputation as the top-ranked stand-alone institute for biomedical research in the United States (Nature Index, 2019).

Lab Overview:
The Disney group is a chemical biology laboratory focused on developing rational approaches to design highly selective therapeutics from only genome sequence. Known for its prolific output and pioneering research culture, the group has furthered advancements in annotating RNA structure from sequence alongside several novel technologies created in-house. The laboratory’s targeting of RNA by small molecules, an ambitious and highly focused enterprise in pursuit of chemical probe and lead medicine development, is summarized in the Journal of the American Chemical Society (2019) 141:6776-6790.

Other representative publications from the Disney group include:

* Studying disease mediated by RNA repeat expansions that cause genetically defined ALS and dementia:
oNeuron (2014) 83:1043-50
oCell Chemical Biology (2019) 26:179-190

* Targeted RNA degradation and related technologies:
oProceedings of the National Academy of Sciences USA (2020) 117:2406-2411
oJournal of the American Chemical Society (2018) 140:6741-6744
oProceedings of the National Academy of Sciences USA (2019) 116:7799-7804.
oNature Chemical Biology (2017) 13:188-193

* Precision targeted therapeutics for difficult-to-treat cancers and other diseases:
oJournal of the American Chemical Society (2019) 141:2960-2974
oCell Chemical Biology (2018) 25:1086-1094
oProceedings of the National Academy of Sciences USA (2016) 113:5898-903
oProceedings of the National Academy of Sciences USA (2020) 117:1457-1467.

Our Commitment: The Disney group is highly committed to each individual’s professional development during his or her time in the lab. A high impact research project and training plan to support the achievement of short-term as well as long-term career goals is customized for each student.

Contact: Applicants should send their CV and have three letters of reference sent on their behalf directly to Prof. Matthew Disney at disney@scripps.edu.