Postdoctoral position in biophysical investigation of phase separation on protein kinase function – MULDER lab

Aarhus University

A two-year post-doctoral position “Condensates and control of kinase signalling” is available from 1 January 2022 (or soon thereafter) in the group of Prof. Dr. Frans A.A. Mulder at the Department of Chemistry and Interdisciplinary Nanoscience Center (iNANO) at Aarhus University, Denmark. URL: https://pure.au.dk/portal/en/fmulder@chem.au.dk

The position is part of BOUNDLESS (https://boundless.au.dk), an interdisciplinary consortium funded by a synergy grant from the Novo Nordisk Foundation. BOUNDLESS was formed to study signalling in membrane-less organelles, and involves an integration that spans from physics and modelling to clinical medicine.

This project is a close collaboration with the group of Prof. Magnus Kjærgaard (Dept. of Molecular Biology). URL: https://pure.au.dk/portal/en/magnus@mbg.au.dk

Project Goal and Tasks
The project applies protein biochemistry, biophysics and NMR spectroscopy to address the structure-function relationship of kinase signalling in phase-separating systems. Specifically, you will study how the structure, composition, physicochemical properties and dynamics of condensates affect phosphorylation reactions in membrane-less organelles by systematic variation of condensate and substrate properties.

Your profile
We are looking for a knowledgeable, ambitious and creative person to join our team. It is expected that the successful candidate will independently manage the development, implementation of NMR experiments and data analysis, as well as work together with other groups in local and international collaborations. Key elements of the project are (1) generation and purification of isotopically labelled proteins, (2) advanced NMR spectroscopy, (3) protein biochemistry and kinase assays, (4) biophysics, analysis and integration with complementary techniques. Minor involvement in teaching activities may be solicited.

Scientific Surroundings
The Ultra High Field NMR Center at Aarhus University offers a stimulating research environment, covering complementary research activities in the area of liquid state NMR, oriented and MAS solid state NMR, HR-MAS, pulse sequence development, low-field NMR, high-pressure NMR and imaging. The lab is equipped with state-of-the-art spectrometers operating at 950 MHz, 700 MHz, 500 MHz, and 400 MHz. The BioNMR research is embedded within the Department of Chemistry (https://chem.au.dk/en/) and the Interdisciplinary Nanoscience Center (iNANO; http://inano.au.dk). These provide abundant and state-of-the-art techniques in structural and molecular biology.
Aarhus University further provides a strong international research and training environment with excellent professional and private conditions. Foreign employees can get help and information from the AU International Center (http://www.au.dk/en/internationalcentre/) and Work in Denmark (https://workindenmark.dk/). Tax reduction schemes for researchers may apply.

For information about our laboratory, activities and recent publications please follow these links:
Link to the BOUNDLESS consortium
Link to the Danish Center for Ultrahigh Field NMR Spectroscopy
Link to Mulder lab publications and citations
Link to the professional website of Frans Mulder at Aarhus University


Qualifications and Conditions of Employment

The applicant should:

  • hold a PhD degree in structural (bio)chemistry or (protein) biophysics, preferentially with experience in NMR spectroscopy and/or the investigation of liquid-liquid phase separation.
  • demonstrate proven scientific excellence.
  • be able to work independently and participate creatively in refining project directions.
  • have good collegial, oral and written communication skills.


Place of work and area of employment

The place of work is Gustav Wieds Vej 14, 8000 Aarhus C, and the area of employment is Aarhus University with related departments.

For further information:
Applicants seeking further information are invited to contact:
Prof. Dr. Frans A.A. Mulder
Interdisciplinary Nanoscience Center (iNANO) and
Department of Chemistry, Aarhus University
Phone  +45 51 44 73 44
Email  fmulder@chem.au.dk
nmr.au.dk // inano.au.dk

To apply for this job please visit www.ofir.dk.

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