Website St. Jude Children's Research Hospital
The Mittag laboratory invites applications for a Postdoctoral Research Fellow to work on an interdisciplinary project that will involve in vitro biophysics studies of phase separation and cell biological approaches to assess function. The latter component is in collaboration with Linda Hendershot’s laboratory in the Department of Tumor Cell Biology. The project seeks to delineate the molecular mechanisms by which cancer mutations in the tumor suppressor SPOP, a ubiquitin ligase subunit, result in dysregulation of substrates. An important goal is to assess the role of phase separation for SPOP function.
Our recent work on this system can be found here: Marzahn et al. EMBO J 2016 (https://pubmed.ncbi.nlm.nih.gov/27220849/), Bouchard et al. Mol Cell 2018 (https://pubmed.ncbi.nlm.nih.gov/30244836/) and Schmit et al. JACS 2020 (https://pubmed.ncbi.nlm.nih.gov/31845799/).
The successful candidate will join a highly collaborative laboratory focused on elucidating mechanisms and function of biomolecular condensates in the Department of Structural Biology, with access to state-of-the-art instrumentation and expertise in NMR spectroscopy, X-ray crystallography, cryo-EM, single molecule techniques, and protein technology. St. Jude Children’s Research Hospital is a Fortune 100 Best Company that offers competitive salary and benefits.
Tanja Mittag, PhD
Department of Structural Biology
St. Jude Children’s Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
To apply for this job please visit postdoc-stjude.icims.com.