Research Associate – Computer Simulations and Statistical Mechanics of Chromatin Organisation (Fixed Term)

Website University of Cambridge

Fixed-term: The funds for this post are available for 2 years in the first instance.

Applications are invited for a postdoctoral position to develop computational approaches to study the physical determinants of liquid-liquid phase separation of chromatin and chromatin-binding proteins. The post is available for a fixed-term period of 2 years starting on 1 April 2021 (or mutually agreed date shortly after), with possible extension for a third year. The position allows considerable flexibility in research topics within the main theme. Guided by experimental observations and physicochemical information, the Collepardo group develops theoretical methods and multiscale computational models to investigate physical and molecular mechanisms that regulate the organization of biomolecules, including chromatin, inside cells (Farr et al., Nat Comms, 2021; Krainer/Welsh/Joseph, Nat Comms, 2021; Espinosa et al. PNAS 2020; Sridhar et al., PNAS, 2020).

The successful candidate will join the research group of Dr. Rosana Collepardo ( based at the Chemistry and Genetics Departments, University of Cambridge.

The proposed research project is particularly suitable for candidates who have extensive experience with LAMMPS, experience in developing coarse-grained models, polymer models, and/or in developing and applying Molecular Dynamics and/or Monte Carlo simulations to biomolecular systems or condensed matter systems. Experience in chromatin structure is a plus.

The successful candidate will have strong experience in molecular modelling and simulations and statistical mechanics and will hold (or be about to obtain) a PhD/DPhil in physics, chemistry, or a closely related field, with a strong interest in biological systems.

The role holder responsibilities will include carrying out their research in computer simulations and statistical mechanics of chromatin liquid-liquid phase separation. Related tasks will include collaborating in the preparation of reports and journal articles, presenting papers at conferences and workshops, representing the group at meetings and seminars, and supervision of graduate students.

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Informal enquiries can be addressed via email to Dr. Rosana Collepardo

Please quote reference MA25972 on your application and in any correspondence about this vacancy.

The Department holds an Athena SWAN silver award for women in Science, Technology, Engineering, Mathematics, and Medicine.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

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