Rohatgi Lab Post-doctoral Position: Protein Phase Separation and Neurodegeneration

Website Rohatgi Lab - Stanford University

Over the past five years, protein phase separation has emerged as a key principle in cell organization, with particular implications for the mechanisms of neurodegenerative disease. The Rohatgi Lab is recruiting a post-doctoral fellow interested in studying the role of protein phase separation in both the normal function and pathological dysfunction of proteins implicated in neurodegeneration.  We have recently developed a powerful new phase separation reporter based on TDP-43, a protein that is found aggregated in many neurodegerative diseases and mutated in Amyotrophic Lateral Sclerosis (Cell Reports 2016, PMID 4972689). We are using such reporters to understand how phase separation regulates protein function and to understand (and hopefully modify) the factors that regulate the dynamic properties and aggregation propensity of proteins that segregate into liquid droplets.

An ideal candidate would have a Ph.D. in Neurobiology, Cell Biology, Biochemistry or related fields and have experience with the techniques in these areas. Experience with live-cell imaging, neuronal cell culture, iPS-derived neurons and CRISPR methods would be ideal. Please email Raj Rohatgi ( with a copy of your CV and a letter describing your prior research background, current research interests, and names of three references.

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