Sr. VP – Neuromuscular & Cardiopulmonary


Website Dewpoint Therapeutics

The Condensates Company

Dewpoint Therapeutics is building a highly collaborative team to harness the power of biomolecular condensates. Together, we are leveraging a transformative shift in the understanding of cellular biology to discover and advance breakthrough therapeutics for the toughest diseases.

We are searching for a Sr. Vice President – Neuromuscular & Cardiopulmonary to lead the overall strategy, planning, and execution of drug discovery to translational medicine to clinical trials. Reporting to the Chief Scientific Officer, you will be responsible for championing and overseeing the work of drug discovery and translational medicine across all stages of drug development and working with cross-functional clinical development teams to develop clinical trial designs. The ideal candidate is a strategically minded, hands-on translational medicine and early clinical development expert with the responsibility for transitioning projects from research into clinic development, and for the translational and early clinical development strategy for specific diseases. You would have a mix of strong disease knowledge, cutting edge science, but enough early development experience to be able to be autonomous when driving programs into the clinic and through the regulatory process.

In this position you’ll be part of highly collaborative, international, multi-disciplinary team, working in an energizing and supportive startup culture engaged in continuous learning. This role is based at our site in Boston's Seaport district and there is some travel, including international travel, expected 5%-10% of the year. Dewpoint offers competitive salary and benefits.

 In this role you will…

  • Collaborate with colleagues across the R&D organization to foster an end-to-end view of drug development, with a focus on improving patient care
  • Provide medical leadership and translational medicine expertise on cross-functional Project Teams.
  • Provide clear and timely communication and interpretation of study results to department and organizational governance, functional area experts, and development review committees
  • Engage with external academic and industry partners in planning and executing strategy and clinical studies
  • Engage with external scientific and medical experts to bring insight to development programs
  • Develop early clinical development plans that are innovative, safe and create a foundation for decision making
  • Be responsible for Phase 0, First-in-Human, Proof-of-Mechanism and Phase 1 studies throughout development, including validation of innovative clinical biomarkers to support decision making
  • Guide and mentor teams of multidisciplinary discovery scientists, working on early biology, to translate their findings and understanding into highly impactful drug discovery programs
  • Be a critical element in Dewpoint’s approach to create an effective bridge between discovery research and clinical development
  • Become a valuable contributor to other initiatives as they arise in our fast paced, startup environment

To do that you will need…

  • MD or MD/PhD and at least 8+ years of broad bio/pharmaceutical industry experience in drug development, coupled with at least 3+ years of experience of leading projects in industry from translational medicine to clinical or PhD with 8+ years of translational or clinical experience
  • Strong record of basic and/or translational research productivity
  • Early clinical development experience in an industry setting
  • Experience with first-in-class clinical trial design, patient selection, regulatory discussion, and a programmatic approach to learn about a new mechanism in the clinic
  • Expertise in Neuromuscular & Cardiopulmonary diseases with at least some experiences that range from Discovery through Clinical POC
  • Proven experience leading teams in the development of specific small molecules through preclinical development, IND filing, and initiation of clinical trials
  • Proven ability to effectively build alliances across functions, based on end-to-end drug development thinking and experience
  • Ability to collaborate in a multidisciplinary and dynamic environment and experience in mentoring and leading scientific teams
  • Ability to communicate effectively in English, the shared language of our multicultural team
About Dewpoint
Dewpoint Therapeutics is the first company founded to apply the emerging discipline of biomolecular condensates to drug discovery. Dewpoint believes that a vast range of conditions have pathways that are regulated by condensates or arise from the dysfunction of condensates — including cancer, neurodegeneration, and metabolic disease. Dewpoint scientists are working in Boston, MA, and Dresden and Berlin, Germany, to translate condensate biology into treatments for the toughest diseases.
Dewpoint strives to cultivate an inclusive international community that welcomes and empowers everyone. We reject racism, discrimination, harassment, brutality, and all other manifestations of hate. We draw strength from diversity.

Dewpoint is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, or veteran status.

Please, no solicitations by agencies.

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