Staff Scientist- Cell and Molecular Biology

The Kriwacki lab seeks to understand how phase separation drives the condensation of biomolecules to create liquid-like bodies that mediate diverse biological processes. Importantly, aberrant biomolecular condensation is associated with several devastating human diseases, including cancer and neurodegeneration. A new initiative in the laboratory addresses the role of aberrant phase separation by fusion oncoproteins as drivers in cancer ( e.g ., NUP98 fusions in AML & AEL) and we seek an analytical, critical thinking, and self-motivated cell biologist to join our team. The Staff Scientist will be responsible for conducting cutting edge research on phase separation by cancer-associated fusion oncoproteins in cells, their effects on chromatin structure and function, and their roles in cellular transformation. The Staff Scientist will also contribute to the training of postdoctoral fellows and students and the management of their projects, and coordinate collaborative projects with internal and external investigators.

The Ideal Candidate Will Have

• • a PhD degree in Cell Biology, Chromatin Structure/Function, Epigenetics or related field
  • a minimum of 5 years post-graduate experience with cell biology methods including tissue culture (primary and immortalized cell lines), functional genomics methods (e.g., RNA-seq, CHIP-seq, 3C-based methods, etc.), and confocal fluorescence microscopy and quantitative image analysis of cells. Experience with gene editing is desired.
  • project management experience
  • scientific writing experience
  • excellent organizational and communication skills
  • prior experience with biomolecular condensates is highly desired, as also is experience with cellular models of cancer

To Learn More About Our Work, Follow These Links

How does the most common ALS mutation doom cells?

How do molecular partners form dynamic scaffolding for protein machinery?

Key inner control mechanism of cell’s “smart glue”

Protein glue that holds biomolecules within the nucleolus
Minimum Education

• A Ph.D. in an appropriate scientific field is required

Minimum Experience

• A minimum of five (5) years of relevant and productive (combined) years postdoctoral research associate or five (5) years of combined academic experience at the postdoctoral level or above.

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St. Jude is an Equal Opportunity Employer

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