Advanced materials (Deerfield Beach, Fla)
Must Reads
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Emerging Implications of Phase Separation in Cancer
Nature
Living material assembly of bacteriogenic protocells
Science translational medicine
Poly(ADP-ribose) promotes toxicity of C9ORF72 arginine-rich dipeptide repeat proteins
Nature cell biology
Heat-shock chaperone HSPB1 regulates cytoplasmic TDP-43 phase separation and liquid-to-gel transition
Nature
Capillary forces generated by biomolecular condensates
Advanced materials (Deerfield Beach, Fla)
Molecularly Engineered Protein Glues with Superior Adhesion Performance
Trends in Pharmacological Sciences
Biomolecular condensates: new opportunities for drug discovery and RNA therapeutics
Mariano Oppikofer
Project Lead, Pfizer, Inc.
By taking a deep dive into the field of RNA therapeutics, our article complements the great review published by our Dewpoint colleagues in Nature Reviews Drug Discovery entitled "Modulating biomolecular condensates: a novel approach to drug discovery". We provide readers with forward-looking insights into a drug discovery era that integrates the evolving fields of biomolecular condensates and RNA therapeutics to deliver novel opportunities for patients.
bioRxiv
Androgen receptor condensates as drug targets
Nature reviews Drug discovery
Modulating biomolecular condensates: a novel approach to drug discovery
Nature
A condensate dynamic instability orchestrates actomyosin cortex activation
Science (New York, NY)
LLPS of FXR1 drives spermiogenesis by activating translation of stored mRNAs
Science (New York, NY)
Meiotic exit in Arabidopsis is driven by P-body-mediated inhibition of translation
Nature
A mitotic chromatin phase transition prevents perforation by microtubules
Advanced materials (Deerfield Beach, Fla)
Optothermally Programmable Liquids with Spatiotemporal Precision and Functional Complexity
Array
VIDEO: Ankur Jain on Nucleic Acid Phase Separation
Nature immunology
Deactylation by SIRT1 enables liquid-liquid phase separation of IRF3/IRF7 in innate antiviral immunity
Nature genetics
Hijacking of transcriptional condensates by endogenous retroviruses
Nature chemical biology
Systematic discovery of biomolecular condensate-specific protein phosphorylation
Advanced materials (Deerfield Beach, Fla)