Kitchen Table Talk
Must Reads
Developmental Cell
Phase Separation-A Physical Mechanism for Organizing Information and Biochemical Reactions
Jill Bouchard
Contributing editor, Condensates.com
Our good friend Rohit Pappu wrote a nice commentary introducing a series of reviews on phase separation in the latest issue of Developmental Cell. Check out each of the 7 below: 1) Phase Separation in Germ Cells and Development 2) LLPS in neuronal development and synaptic signaling 3) Phase Separation in Membrane Biology 4) Phase Separation and Neurodegenerative Diseases 5) Emerging Roles for Phase Sseparation in Plants 6) Biomolecular Condensates and Gene Activation in Development and Disease 7) Visualizing Molecular Architectures of Cellular Condensates
Nature Cell Biology
Mitochondrial RNA granules are fluid condensates positioned by membrane dynamics
Science
Beyond aggregation: Pathological phase transitions in neurodegenerative disease
Jill Bouchard
Contributing editor, Condensates.com
Have you seen this review yet? I think it's gonna be a great one!
Cell
Phase Separation of Disease-Associated SHP2 Mutants Underlies MAPK Hyperactivation
bioRxiv
Phase Separation Can Increase Enzyme Activity by Concentration and Molecular Organization
Nature cell biology
Nucleated transcriptional condensates amplify gene expression
Nature
A protein assembly mediates Xist localization and gene silencing
Nature cell biology
lncRNA DIGIT and BRD3 protein form phase-separated condensates to regulate endoderm differentiation
Cell
Formation of NPR1 Condensates Promotes Cell Survival during the Plant Immune Response
Nature reviews Molecular cell biology
The nucleolus as a multiphase liquid condensate
Nature
A prion-like domain in ELF3 functions as a thermosensor in Arabidopsis
Jill Bouchard
Contributing editor, Condensates.com
Unsurprisingly, this thermosensor functions via temperature-mediated phase separation. ;)
Cell
Phase Separation of a PKA Regulatory Subunit Controls cAMP Compartmentation and Oncogenic Signaling
Cell
Head-to-Tail Polymerization in the Assembly of Biomolecular Condensates
Kitchen Table Talk
Rohit Pappu on Molecular Grammar of Condensates – Part 3
bioRxiv
Ligand Effects on Phase Separation of Multivalent Macromolecules
Jill Bouchard
Contributing editor, Condensates.com
It was so great to see Rohit Pappu present some of this work last week at his final talk in his 3-part series on molecular grammar of condensates!
bioRxiv
Hydration-dependent phase separation of a prion-like protein regulates seed germination during water stress.
Kitchen Table Talk
Rohit Pappu on Molecular Grammar of Condensates – Part 2
Nature chemistry
De novo engineering of intracellular condensates using artificial disordered proteins
Kitchen Table Talk