Kitchen Table Talk
Must Reads
Nature chemistry
De novo engineering of intracellular condensates using artificial disordered proteins
Kitchen Table Talk
Rohit Pappu on Molecular Grammar of Condensates – Part 1
Nature cell biology
Biophysical properties of AKAP95 protein condensates regulate splicing and tumorigenesis
Nature Reviews, Microbiology
Formation and function of bacterial organelles
Jill Bouchard
Contributing editor, Condensates.com
The authors cover both membrane-bound and membrane-less organelles...should be a good read.
Nature
MeCP2 links heterochromatin condensates and neurodevelopmental disease
Trends in biochemical sciences
Biomolecular Condensates in the Nucleus
Jill Bouchard
Contributing editor, Condensates.com
Need an update on what's new with nuclear condensates? This will be a good place to start!
Nature nanotechnology
Biomolecular condensates undergo a generic shear-mediated liquid-to-solid transition
Nature reviews Molecular cell biology
RNA Contributions to the Form and Function of Biomolecular Condensates
Jill Bouchard
Contributing editor, Condensates.com
This review covers some of the principles Amy touched upon when she visited us for her Kitchen Table Talk on RNA-driven phase separation.
bioRxiv
Spatial engineering of E. coli with addressable phase-separated RNAs
Proceedings of the National Academy of Sciences of the United States of America
Phase Transition of RNA-protein Complexes Into Ordered Hollow Condensates
Jill Bouchard
Contributing editor, Condensates.com
So glad to see this work out! We really enjoyed getting a sneak peak at Priya Banerjee's Kitchen Table talk. I hope you'll enjoy the video and paper too!
Science (New York, NY)
Partitioning of Cancer Therapeutics in Nuclear Condensates
bioRxiv
Specific viral RNA drives the SARS CoV-2 nucleocapsid to phase separate
Jill Bouchard
Contributing editor, Condensates.com
Here's another condensates study getting into how SARS CoV-2 works! I especially like the part where they show small molecules can alter these viral condensates inside mammalian cells.
Nature
LEM2 Phase Separation Promotes ESCRT-mediated Nuclear Envelope Reformation
Science advances
Sequence-based Engineering of Dynamic Functions of Micrometer-Sized DNA Droplets
Jill Bouchard
Contributing editor, Condensates.com
The sooner we learn how to control condensates, the sooner we can harness their power for cool applications. This study gets us one step closer.
bioRxiv
Observation of an α-synuclein liquid droplet state and its maturation into Lewy body-like assemblies
Nature chemistry
α-Synuclein Aggregation Nucleates Through Liquid-Liquid Phase Separation
Nature Genetics
Selective Mediator Dependence of Cell-Type-Specifying Transcription
Jill Bouchard
Contributing editor, Condensates.com
The authors argue that their data agrees with the model where phase separation plays an important role in transcription initiation.
bioRxiv
Structure−function properties in disordered condensates
Jill Bouchard
Contributing editor, Condensates.com
It's interesting to see how the structures outside and inside condensates matter for function.
Nature