Cell
Must Reads
Science
HSP70 chaperones RNA-free TDP-43 into anisotropic intranuclear liquid spherical shells
Cell
RNA-Mediated Feedback Control of Transcriptional Condensates
Cell
Condensed Chromatin Behaves like a Solid on the Mesoscale In Vitro and in Living Cells
Cell
Single-Molecule Imaging Reveals Translation of mRNAs Localized to Stress Granules
Jill Bouchard
Contributing editor, Condensates.com
Here's a big nail in the coffin for the hypothesis that stress granules are for storage.
Science (New York, NY)
Protein condensates as aging Maxwell fluids
Nature Cell Biology
Phase separation of SERRATE drives dicing body assembly and promotes miRNA processing in Arabidopsis
Nature reviews Genetics
RNA-binding proteins in human genetic disease
Nature nanotechnology
Structural and dynamics analysis of intrinsically disordered proteins by high-speed atomic force microscopy
Nature Plants
The structural basis of Rubisco phase separation in the pyrenoid
Nature
Assembly of synaptic active zones requires phase separation of scaffold molecules
Nature medicine
Dysregulated ribonucleoprotein granules promote cardiomyopathy in RBM20 gene-edited pigs
Nature reviews Molecular cell biology
A framework for understanding the functions of biomolecular condensates across scales
Nature genetics
MLL4-associated condensates counterbalance Polycomb-mediated nuclear mechanical stress in Kabuki syndrome
Webinar
Life Sciences School “Condensates and Phase separation in Biology” YouTube Channel
Cell
Cellular Control of Viscosity Counters Changes in Temperature and Energy Availability
Kitchen Table Talk
Jeremy Schmit on the Biophysical Basis of Condensate Functionality
Developmental Cell
Phase Separation-A Physical Mechanism for Organizing Information and Biochemical Reactions
Jill Bouchard
Contributing editor, Condensates.com
Our good friend Rohit Pappu wrote a nice commentary introducing a series of reviews on phase separation in the latest issue of Developmental Cell. Check out each of the 7 below: 1) Phase Separation in Germ Cells and Development 2) LLPS in neuronal development and synaptic signaling 3) Phase Separation in Membrane Biology 4) Phase Separation and Neurodegenerative Diseases 5) Emerging Roles for Phase Sseparation in Plants 6) Biomolecular Condensates and Gene Activation in Development and Disease 7) Visualizing Molecular Architectures of Cellular Condensates
Nature Cell Biology
Mitochondrial RNA granules are fluid condensates positioned by membrane dynamics
Science
Beyond aggregation: Pathological phase transitions in neurodegenerative disease
Jill Bouchard
Contributing editor, Condensates.com
Have you seen this review yet? I think it's gonna be a great one!