Science (New York, NY)
Most Recent
Nature
DEAD-box ATPases are global regulators of phase-separated organelles
Neuron
Inhibition of Axon Regeneration by Liquid-like TIAR-2 Granules
Nature
Arabidopsis FLL2 promotes liquid-liquid phase separation of polyadenylation complexes
Journal of the American Chemical Society
Pressure-Sensitive and Osmolyte-Modulated Liquid-Liquid Phase Separation of Eye-Lens γ-Crystallins
Jill Bouchard
Editor in Chief, Condensates.com
Cool! Deep sea fish have extra osmolytes in their eyes to stabilize their condensates at high pressure, giving them an adaptive advantage! I wonder if these insights could help us treat cataracts?
Current opinion in genetics & development
Implications of liquid-liquid phase separation in plant chromatin organization and transcriptional control
Jill Bouchard
Editor in Chief, Condensates.com
This is an interesting review & prospective on what condensates may do in plants.
Expert review of proteomics
Targeting intrinsically disordered proteins in neurodegenerative and protein dysfunction diseases: another illustration of the D(2) concept
FEBS letters
Fuzzy complexes: Specific binding without complete folding
Jill Bouchard
Editor in Chief, Condensates.com
This is a nice review detailing our growing understanding of transient interactions... they no doubt also play a large role in condensates.
Journal of the American Chemical Society
Folding and binding of an intrinsically disordered protein: fast, but not ‘diffusion-limited’
Jill Bouchard
Editor in Chief, Condensates.com
The inverse dependence on solvent viscosity should become very important inside condensates.
Proceedings of the National Academy of Sciences of the United States of America
Mapping low-affinity/high-specificity peptide-protein interactions using ligand-footprinting mass spectrometry
Jill Bouchard
Editor in Chief, Condensates.com
This could be a very useful method for finding what drives promiscuous proteins into condensates.
Nature cell biology
Functional transcription promoters at DNA double-strand breaks mediate RNA-driven phase separation of damage-response factors
Molecular cell
Mediator Condensates Localize Signaling Factors to Key Cell Identity Genes
Jill Bouchard
Editor in Chief, Condensates.com
A cool piece of work showing how signaling molecules use their intrinsically disordered tails to find/enter condensates at super-enhancers. See for yourself!
Journal of cellular physiology
Age-related neurodegenerative diseases
Cell
Organization of Chromatin by Intrinsic and Regulated Phase Separation
Jill Bouchard
Editor in Chief, Condensates.com
Check out this paper to gain insights into how our genes are regulated by phase separation.
Biophysical journal
Quantifying Dynamics in Phase-Separated Condensates Using Fluorescence Recovery after Photobleaching
Jill Bouchard
Editor in Chief, Condensates.com
FRAP is a used commonly to show that condensates have liquid properties, but what does it really tell us? This is worth a read to make sure you are analyzing your data correctly and drawing the right conclusions.
Nature
DDX3X acts as a live-or-die checkpoint in stressed cells by regulating NLRP3 inflammasome
Jill Bouchard
Editor in Chief, Condensates.com
This is quite the interesting connection between stress granules and the inflammasome to determine cell-fate decisions!
Nature reviews Cancer
Targeting transcription factors in cancer – from undruggable to reality
Jill Bouchard
Editor in Chief, Condensates.com
I'm sure this review will detail some important strategies for making cancer therapeutics that will nicely complement our knowledge of condensates!
Trends in neurosciences
Physiological, Pathological, and Targetable Membraneless Organelles in Neurons
Neuron
Phase Separation-Mediated TARP/MAGUK Complex Condensation and AMPA Receptor Synaptic Transmission
Cell
Amyloid-like Assembly Activates a Phosphatase in the Developing Drosophila Embryo
Jill Bouchard
Editor in Chief, Condensates.com
A cool study showing how not all amyloid-like assemblies are bad!