bioRxiv
Uncovering Differences in Hydration Free Energies for Model Compound Mimics of Charged Sidechains of Amino Acids
Jill Bouchard
Editor in Chief, Condensates.com
This work helps explain a lot of phase behavior in charged protein sequences.
Most Recent
bioRxiv
Design of intrinsically disordered proteins that undergo phase transitions with lower critical solution temperatures
Frontiers in cell and developmental biology
Stress Granules in the Post-transcriptional Regulation of Immune Cells
Jill Bouchard
Editor in Chief, Condensates.com
There could be some important insights about stress granules in this review if you're looking into targeting them therapeutically.
Molecular cell
Stress-induced nuclear condensation of NELF drives transcriptional downregulation
BioRxiv
RNA polymerase II clusters form in line with liquid phase wetting of chromatin
Analytical chemistry
Dynamic Monitoring of Phase-Separated Biomolecular Condensates by Photoluminescence Lifetime Imaging
Journal of molecular cell biology
Membrane-associated phase separation: organization and function emerge from a two-dimensional milieu
Life science alliance
1,6-hexanediol rapidly immobilizes and condenses chromatin in living human cells
Jill Bouchard
Editor in Chief, Condensates.com
This is not the first (and probably not the last) cautionary note about using 1,6-hexanediol in condensate studies.
bioRxiv
A modular platform for engineering function of natural and synthetic biomolecular condensates
Nucleic acid therapeutics
Solid-Phase Separation of Toxic Phosphorothioate Antisense Oligonucleotide-Protein Nucleolar Aggregates Is Cytoprotective
Cell reports
Predicting protein condensate formation using machine learning
CNS & neurological disorders drug targets
Functional Neuroproteomics: An imperative approach for unravelling protein implicated complexities of brain
Jill Bouchard
Editor in Chief, Condensates.com
This review could be useful for figuring out how to get data on condensates in neurons.
Kitchen Table Talk
Must ReadVIDEO: Serena Sanulli on Chromatin and its Phases
Mar
24
Shana Elbaum-Garfinkle on Emergent Material Properties of Biomolecular Condensates
Wednesday, March 24, 2021
Briefings in bioinformatics
Computational resources for identifying and describing proteins driving liquid-liquid phase separation
Journal of molecular biology
Designer condensates: a toolkit for the biomolecular architect
Journal of molecular biology
Mechanistic inferences from analysis of measurements of protein phase transitions in live cells
bioRxiv
piRNAs Coordinate poly(UG) Tailing to Prevent Aberrant and Permanent Gene Silencing
Jill Bouchard
Editor in Chief, Condensates.com
The authors put forth a couple of models about how condensates are involved in this new function of piRNAs. Check them out in the discussion.
bioRxiv
dSCOPE: a software to detect sequences critical for liquid-liquid phase separation
Jill Bouchard
Editor in Chief, Condensates.com
This database should be helpful for lots of folks out there. I’ve saved it in our library of Resources–check it out here: https://condensates.com/resources/dscope/
Viruses
Reovirus and the Host Integrated Stress Response: On the Frontlines of the Battle to Survive
Jill Bouchard
Editor in Chief, Condensates.com
Here's another data point on how viruses use stress granules to evade the immune response.