Nature cell biology
Most Recent
Nature cell biology
Kinetically distinct phases of tau on microtubules regulate kinesin motors and severing enzymes
Cells
Membrane-Bound Meet Membraneless in Health and Disease
Nature
Organization and regulation of gene transcription
bioRxiv
CDK-regulated phase separation seeded by histone genes ensures precise growth and function of Histone Locus Bodies
bioRxiv
Multivalent proteins rapidly and reversibly phase-separate upon osmotic cell volume change
bioRxiv
Mitochondrial RNA granules are fluid condensates, positioned by membrane dynamics
Jill Bouchard
Editor in Chief, Condensates.com
A cool use of super resolution microscopy to dive deep into mitochondria and see all the phases at play!
bioRxiv
Nucleated transcriptional condensates amplify gene expression
bioRxiv
Small molecules for modulating protein driven liquid-liquid phase separation in treating neurodegenerative disease
Jill Bouchard
Editor in Chief, Condensates.com
Cool! One step closer to treating ALS by modulating phase behavior.
bioRxiv
Deep-learning enables proteome-scale identification of phase-separated protein candidates from immunofluorescence images
bioRxiv
A heterochromatin-specific RNA export pathway facilitates piRNA production
bioRxiv
Phase separation of zonula occludens proteins drives formation of tight junctions
bioRxiv
A quantitative inventory of yeast P body proteins reveals principles of compositional specificity
Genes & development
Evaluating phase separation in live cells: diagnosis, caveats, and functional consequences
Jill Bouchard
Editor in Chief, Condensates.com
This is an important cautionary tale, and a call for better diagnostic assays to prove LLPS.
Cell stem cell
The RNA Helicase DDX6 Controls Cellular Plasticity by Modulating P-Body Homeostasis
Jill Bouchard
Editor in Chief, Condensates.com
This was quite the meeting of the minds to show an important link between P bodies and cell fate decisions in stem cells.
Nucleic acids research
PhaSepDB: a database of liquid-liquid phase separation related proteins
Jill Bouchard
Editor in Chief, Condensates.com
This is #2/4 condensate-related database featured in the 2020 Nucleic Acids Database Issue. I like that this one catalogs which membraneless organelles a given protein has been reported in. I've saved it in our library of Resources--check it out here: https://condensates.com/resources/phasepdb/
Nature reviews Neuroscience
Stress granules and neurodegeneration
Jill Bouchard
Editor in Chief, Condensates.com
This is a nice review with important insights into potential therapeutic treatments.
Molecular cell
The Control Centers of Biomolecular Phase Separation: How Membrane Surfaces, PTMs, and Active Processes Regulate Condensation
Nature
HP1 reshapes nucleosome core to promote heterochromatin phase separation
Nucleic acids research
PhaSePro: the database of proteins driving liquid-liquid phase separation
Jill Bouchard
Editor in Chief, Condensates.com
This is #3/4 condensate-related database featured in the 2020 Nucleic Acids Database Issue. I like that this one highlights the structural features driving phase separation....It's quite thorough! I've saved it in our library of Resources--check it out here: https://condensates.com/resources/phasepro/