Journal of the American Chemical Society
Most Recent
Proceedings of the National Academy of Sciences of the United States of America
Glucocorticoid receptor condensates link DNA-dependent receptor dimerization and transcriptional transactivation
JCI insight
Characterization of HNRNPA1 mutations defines diversity in pathogenic mechanisms and clinical presentation
Jill Bouchard
Editor in Chief, Condensates.com
The mutations caused a range of effects on phase separation and stress granule dynamics.
Biochemistry
Liquid-Liquid Phase Separation in Biology: Specific Stoichiometric Molecular Interactions vs Promiscuous Interactions Mediated by Disordered Sequences
The journal of physical chemistry letters
Interplay between Kinetics and Dynamics of Liquid-Liquid Phase Separation in a Protein Solution Revealed by Coherent X-ray Spectroscopy
Journal of the American Chemical Society
Different Folding States from the Same Protein Sequence Determine Reversible vs Irreversible Amyloid Fate
Jill Bouchard
Editor in Chief, Condensates.com
This work argues amyloids can be reversible and irreversible.
Science Advances
FUS-ALS mutants alter FMRP phase separation equilibrium and impair protein translation
Journal of virology
EV71 2A Protease inhibits P-body formation to promote viral RNA synthesis
Jill Bouchard
Editor in Chief, Condensates.com
I see a lot of interesting work about the role of stress granules in viral infections. This work looks at P bodies. Check out this paper for a fresh take on condensates in infections.
The EMBO journal
Tudor staphylococcal nuclease is a docking platform for stress granule components and is essential for SnRK1 activation in Arabidopsis
Jill Bouchard
Editor in Chief, Condensates.com
We saw this paper come out on bioRxiv last year, and it's nice to see it published in EMBO J now! Check out our post about the original bioRxiv preprint here.
bioRxiv
Regulation of a bacterial histidine kinase by a phase separating scaffolding protein
BioRxiv
Mechanisms of translation inhibition and suppression of Stress Granule formation by cisplatin
eLife
Pak1 kinase controls cell shape through ribonucleoprotein granules
Nature communications
High-depth spatial transcriptome analysis by photo-isolation chemistry
Jill Bouchard
Editor in Chief, Condensates.com
This looks to be a useful new method to detect genes expressed in condensates.
Biochimica et biophysica acta Molecular cell research
Liquid-liquid phase separation as a common organizing principle of intracellular space and biomembranes providing dynamic adaptive responses
Nature Reviews Molecular Cell Biology
RNA polymerase II transcription compartments: from multivalent chromatin binding to liquid droplet formation?
Professor Anthony Hyman is a new member of the Leopoldina
Biochimica et Biophysica Acta Molecular Cell Research
M33 condenses chromatin through nuclear body formation and methylation of both histone H3 lysine 9 and lysine 27
Nature Communications
Nuclear condensates of p300 formed though the structured catalytic core can act as a storage pool of p300 with reduced HAT activity
Acta neuropathologica
HnRNP K mislocalisation is a novel protein pathology of frontotemporal lobar degeneration and ageing and leads to cryptic splicing
Jill Bouchard
Editor in Chief, Condensates.com
Spoiler alert for condensate fans: HnRNP K mislocalizes to cytoplasmic puncta that are not stress granules.
Journal of the American Chemical Society