Frontiers In Molecular Biosciences
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Nature
Phase separation drives aberrant chromatin looping and cancer development
bioRxiv
Accurate model of liquid-liquid phase behaviour of intrinsically-disordered proteins from data-driven optimization of single-chain properties
Nature Structure & Molecular Biology
Fusion proteins form onco-condensates
Jill Bouchard
Editor in Chief, Condensates.com
Here's the News and Views article about the recent Nature paper on the role of phase separation in chromatin looping and cancer.
Journal of cell science
Condensation of pericentrin proteins in human cells illuminates phase separation in centrosome assembly
The journal of physical chemistry B
Pressure and Temperature Phase Diagram for Liquid-Liquid Phase Separation of the RNA-Binding Protein Fused in Sarcoma
Proceedings of the National Academy of Sciences of the United States of America
N-terminal tail prolines of Gal-3 mediate its oligomerization/phase separation
Jill Bouchard
Editor in Chief, Condensates.com
Here’s the Commentary article about the recent PNAS paper on the glycan-mediated LLPS of the Gal-3 carb-binding protein.
Cell reports
TOR signaling regulates liquid phase separation of the SMN complex governing snRNP biogenesis
bioRxiv
Regulation of the Molecular Shuttle Service: A Multiscale Model of Aquaporin 2 Recycling
Jill Bouchard
Editor in Chief, Condensates.com
The authors think condensates play a role in this process, and are looking for biomolecules that are involved in cAMP compartmentalization.
bioRxiv
RNA at the surface of phase-separated condensates impacts their size and number
bioRxiv
Pickering stabilization of a dynamic intracellular emulsion
Jill Bouchard
Editor in Chief, Condensates.com
Have you heard of Pickering emulsion theory? (I hadn't either. ;) ) This paper shows how it applies to condensates.
Cell Reports
Positive feedback between the T cell kinase Zap70 and its substrate LAT acts as a clustering-dependent signaling switch
Jill Bouchard
Editor in Chief, Condensates.com
Here's a new optogenetic method that may come in handy for answering condensate-related questions.
Journal of the American Chemical Society
Quadruplex Folding Promotes the Condensation of Linker Histones and DNAs via Liquid-Liquid Phase Separation
IDPSeminars: Rosana Collepardo & Shasha Chong — June 24
Thursday, June 24, 2021
bioRxiv
Identification of the stress granule transcriptome via RNA-editing in single cells and in vivo
Jill Bouchard
Editor in Chief, Condensates.com
This could be a very useful method for research on other RNA-enriched condensates.
bioRxiv
Multivalent interactions with RNA drive RNA binding protein recruitment and dynamics in biomolecular condensates in Xenopus oocytes
People & Culture (HR) Administrator (Temp)
Dewpoint Therapeutics | Boston, MA, USA
ApplyNature Communications
Active coacervate droplets are protocells that grow and resist Ostwald ripening
The journal of physical chemistry B
Protein Phase Separation Arising from Intrinsic Disorder: First-Principles to Bespoke Applications
Angewandte Chemie (International ed in English)
Unambiguous tracking of protein phosphorylation by fast high-resolution FOSY NMR
Jill Bouchard
Editor in Chief, Condensates.com
This could be a useful method for identifying regulated regions of condensate-loving IDPs.