Executive Assistant to the CSO
Dewpoint Therapeutics | Boston, MA, USA
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Scientist/Sr. Scientist Exploratory Biology (m/f/d)
Dewpoint Therapeutics | Dresden, Germany
ApplySenior Scientist – Virology
Dewpoint Therapeutics | Boston, MA, USA
ApplySenior Research Associate or Scientist – Virology
Dewpoint Therapeutics | Boston, MA, USA
ApplyMolecular genetics & genomic medicine
SUMOylated Senataxin functions in genome stability, RNA degradation, and stress granule disassembly, and is linked with inherited ataxia and motor neuron disease
Jill Bouchard
Managing editor, Condensates.com
It looks like this protein may have a cell-cycle dependent localization between stress granules and DNA damage loci.
bioRxiv
Imaging and single cell sequencing analyses of super-enhancer activation mediated by NF-κB in B cells
RNA (New York, NY)
Recruitment of endoplasmic reticulum-targeted and cytosolic mRNAs into membrane-associated stress granules
Sr. VP – Neuromuscular & Cardiopulmonary
Dewpoint Therapeutics | Boston, MA, USA
ApplyCell reports
Deletion of RBMX RGG/RG motif in Shashi-XLID syndrome leads to aberrant p53 activation and neuronal differentiation defects
Jill Bouchard
Managing editor, Condensates.com
And the RGG domain was also required for condensate formation in U2OS cells.
Cell reports
Site-specific O-GlcNAcylation of Psme3 maintains mouse stem cell pluripotency by impairing P-body homeostasis
The Journal of cell biology
Small-molecule modulators of INAVA cytosolic condensate and cell-cell junction assemblies
The Journal of biological chemistry
The N-terminal domain of the Schaaf-Yang syndrome protein MAGEL2 likely has a role in RNA metabolism
Jill Bouchard
Managing editor, Condensates.com
It looks like this disease might happen through a condensate mechanism.
International journal of biological macromolecules
Effect of a good buffer on the fate of metastable protein-rich droplets near physiological composition
bioRxiv
Condensate-mediated reactivation of mumps virus infection under stress
bioRxiv
Nucleolar stress controls mutant Huntingtin toxicity and monitors Huntington disease progression
The FEBS journal
Nuclear speckles: dynamic hubs of gene expression regulation
Comparative biochemistry and physiology Part B, Biochemistry & molecular biology
Dact1 is expressed during chicken and mouse skeletal myogenesis and modulated in human muscle diseases
Jill Bouchard
Managing editor, Condensates.com
This protein happens to be found in "aggregates" inside muscle cells. Go figure, it's also predicted to be disordered and to phase separate.
bioRxiv
Interplay between disordered regions in RNAs and proteins modulates interactions within stress granules and processing bodies
Nucleic Acids Research
Roles of non-canonical structures of nucleic acids in cancer and neurodegenerative diseases
Jill Bouchard
Managing editor, Condensates.com
This review is full of a lot of juicy details about the role of RNA in phase separation.
bioRxiv