The Plant cell
Most Recent
Nature structural & molecular biology
Nucleolus assembly impairment leads to two-cell transcriptional repression via NPM1-mediated PRC2 recruitment
bioRxiv
Multivalent coiled-coil interactions enable full-scale centrosome assembly and strength
BioRxiv
Protein intrinsically disordered regions have a non-random, modular architecture
Matthew Parker
,
Protein intrinsically disordered regions are commonly implicated in biomolecular phase separation. Classifying disordered sequences has been difficult since they lack a unifying sequence organizational principle. This short report describes the development of a statistically robust computational algorithm to quantify linear variance in amino acid composition within a protein sequence. With this approach we unexpectedly found that IDRs of both low and high sequence complexity (but not folded domains) are built from juxtaposed modules with distinct compositional bias. This concept likely represents a fundamental organizational principle of disordered sequences in the sense that it is generalizable, broadly operative, and enables the unbiased sub-division of a sequence into component parts. We hope this will provide a rational approach for pinpointing the functional regions of disordered sequences. The code for these analyses is freely available and easily implemented.
Jonathan O’Connell on High-Throughput Screening in Drug Discovery
Wednesday, July 12, 2023
bioRxiv
Macrophage innate immune gene expression requires dynamic regulation of the nuclear paraspeckle
The journal of physical chemistry B
Time-Dependent Material Properties of Aging Biomolecular Condensates from Different Viscoelasticity Measurements in Molecular Dynamics Simulations
Science advances
A bending rigidity parameter for stress granule condensates
bioRxiv
In situ Quantification of Biomolecular Concentration of Cytoplasmic Membraneless Organelles in a Living Cell
Trends in neurosciences
RNA granules in neuronal plasticity and disease
ACS nano
Phase-Separated Synthetic Organelles Based on Intrinsically Disordered Protein Domain for Metabolic Pathway Assembly in Escherichia coli
Methods in molecular biology (Clifton, NJ)
Analysis of Phase-Separated Biomolecular Condensates in Cancer
Autophagy
SQSTM1/P62 promotes lysophagy via formation of liquid-like condensates maintained by HSP27
Methods in molecular biology (Clifton, NJ)
Gain-of-Function Variomics and Multi-omics Network Biology for Precision Medicine
Soft matter
Membrane curvature sensing by model biomolecular condensates
PLoS computational biology
Self-assembly coupled to liquid-liquid phase separation
bioRxiv
Mutations in tau protein promote aggregation by favoring extended conformations
bioRxiv
Sequence-Dependent Material Properties of Biomolecular Condensates
bioRxiv
SEMORE: SEgmentation and MORphological fingErprinting by machine learning automates super-resolution data analysis
bioRxiv