bioRxiv
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bioRxiv
Physical theory of biological noise buffering by multi-component phase separation
bioRxiv
Role of spatial patterning of N-protein interactions in SARS-CoV-2 genome packaging
Jill Bouchard
Contributing editor, Condensates.com
The authors looked into whether the arrangement of LLPS-promoting and solubilizing sequences in the genome lead to single genome packaging. Read on to learn about generalizable principles of virus compaction.
Biomacromolecules
Self-Assembly of Silk-like Protein into Nanoscale Bicontinuous Networks under Phase-Separation Conditions
mSphere
Association of Zinc Finger Antiviral Protein Binding to Viral Genomic RNA with Attenuation of Replication of Echovirus 7
Jill Bouchard
Contributing editor, Condensates.com
The authors implicate stress granules and potentially other cellular compartments in mediating antiviral effects.
Biomacromolecules
Nanoscopic Dynamics Dictate the Phase Separation Behavior of Intrinsically Disordered Proteins
RNA biology
Identification and initial characterization of POLIII-driven transcripts by msRNA-sequencing
Jill Bouchard
Contributing editor, Condensates.com
It looks like this msRNAseq method may be helpful in identifying medium-sized RNA in other condensates too.
A Newfound Source of Cellular Order in the Chemistry of Life
Pfizer taps Dewpoint Therapeutics in $239M dystrophy drug deal
Cells
Limited Proteolysis-Coupled Mass Spectrometry Identifies Phosphatidylinositol 4,5-Bisphosphate Effectors in Human Nuclear Proteome
Jill Bouchard
Contributing editor, Condensates.com
Do lipids make it into condensates? This method seeks to uncover the complicated relationship between lipids and many proteins that localize to condensates.