A Concentration-Dependent Liquid Phase Separation Can Cause Toxicity upon Increased Protein Expression

Authors Bolognesi B, Lorenzo Gotor N, Dhar R, Cirillo D, Baldrighi M, Tartaglia GG, Lehner B
Details Cell Rep. 2016 Jun 28;16(1):222-231. doi: 10.1016/j.celrep.2016.05.076. Epub 2016 Jun 16
DOI 10.1016/j.celrep.2016.05.076
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Jill Bouchard Recent comment authors
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Jill Bouchard
Jill Bouchard
Editor in Chief, Condensates.com

Have you ever wondered if there’s an alternate explanation for how phase separation of a given protein contributes to disease? Toxicity could be an important feature to consider.