A Concentration-Dependent Liquid Phase Separation Can Cause Toxicity upon Increased Protein Expression
Authors | Bolognesi B, Lorenzo Gotor N, Dhar R, Cirillo D, Baldrighi M, Tartaglia GG, Lehner B |
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Details | Cell Rep. 2016 Jun 28;16(1):222-231. doi: 10.1016/j.celrep.2016.05.076. Epub 2016 Jun 16 |
DOI | 10.1016/j.celrep.2016.05.076 |
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Source | View on PubMed |
Have you ever wondered if there’s an alternate explanation for how phase separation of a given protein contributes to disease? Toxicity could be an important feature to consider.