A quantitative biology approach correlates neuronal toxicity with the largest inclusions of TDP-43
| Authors | Roberta Cascella , Alessandra Bigi , Dylan Giorgino Riffert , Maria Cristina Gagliani , Emilio Ermini , Matteo Moretti , Katia Cortese , Cristina Cecchi , Fabrizio Chiti |
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| Details | Roberta Cascella et al; Sci Adv; 2022; |
| DOI | 10.1126/sciadv.abm6376 |
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| Source | View on PubMed |
This method allowed the authors to “identify and follow, in real time, the contributions of various aspects of TDP-43 localization and aggregation state…” and should be useful for a lot of other disease-related and phase separating proteins.