A quantitative biology approach correlates neuronal toxicity with the largest inclusions of TDP-43

Authors Roberta Cascella , Alessandra Bigi , Dylan Giorgino Riffert , Maria Cristina Gagliani , Emilio Ermini , Matteo Moretti , Katia Cortese , Cristina Cecchi , Fabrizio Chiti 
Details Roberta Cascella et al; Sci Adv; 2022;
DOI 10.1126/sciadv.abm6376
Source View on PubMed

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Jill Bouchard
Jill Bouchard
Editor in Chief, Condensates.com

This method allowed the authors to “identify and follow, in real time, the contributions of various aspects of TDP-43 localization and aggregation state…” and should be useful for a lot of other disease-related and phase separating proteins.