An intrinsically disordered region-mediated confinement state contributes to the dynamics and function of transcription factors

Authors David A Garcia , Thomas A Johnson , Diego M Presman , Gregory Fettweis , Kaustubh Wagh , Lorenzo Rinaldi , Diana A Stavreva , Ville Paakinaho , Rikke A M Jensen , Susanne Mandrup , Arpita Upadhyaya , Gordon L Hager 
Details David A Garcia et al; Mol Cell; 2021;
DOI 10.1016/j.molcel.2021.01.013
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Gordon Hager
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Gordon Hager
Lab Chief, National Inst. of Health

A major breakthrough shows a new mode of T factor dynamics that requires the IDR of a transcription factor, but does not require the DNA binding domain.