An intrinsically disordered region-mediated confinement state contributes to the dynamics and function of transcription factors
Authors | David A Garcia , Thomas A Johnson , Diego M Presman , Gregory Fettweis , Kaustubh Wagh , Lorenzo Rinaldi , Diana A Stavreva , Ville Paakinaho , Rikke A M Jensen , Susanne Mandrup , Arpita Upadhyaya , Gordon L Hager |
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Details | David A Garcia et al; Mol Cell; 2021; |
DOI | 10.1016/j.molcel.2021.01.013 |
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Source | View on PubMed |
A major breakthrough shows a new mode of T factor dynamics that requires the IDR of a transcription factor, but does not require the DNA binding domain.