Apolipoprotein E isoform-specific phase transitions in the retinal pigment epithelium drive disease phenotypes in age-related macular degeneration

Authors Nilsa La Cunza, Li Xuan Tan, Gurugirijha Rathnasamy, Thushara Thamban, Colin J. Germer, Kimberly A. Toops, Aparna Lakkaraju
DetailsbioRxiv. July 16, 2020
DOI10.1101/2020.07.15.201723
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Jill Bouchard
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Jill Bouchard
Contributing editor, Condensates.com

Interesting– the redox-related phase separation of a cholesterol transporter may lead to the deposits causing macular degeneration. AND(!) therapeutically restoring function just happens to interfere with condensate formation.