Arginine-Enriched Mixed-Charge Domains Provide Cohesion for Nuclear Speckle Condensation

Authors Jamie A Greig , Tu Anh Nguyen , Michelle Lee , Alex S Holehouse , Ammon E Posey , Rohit V Pappu , Gregory Jedd 
Details Jamie A Greig et al; Mol Cell; 2020
DOI 10.1016/j.molcel.2020.01.025
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Jill Bouchard
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Jill Bouchard
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Looks like proteins have to think positive to get into nuclear speckles, but that’s not always a good thing. As with all things in life, moderation is key.