Assembly of higher-order SMN oligomers is essential for metazoan viability and requires an exposed structural motif present in the YG zipper dimer

Authors Kushol Gupta , Ying Wen , Nisha S Ninan , Amanda C Raimer  , Robert Sharp , Ashlyn M Spring  , Kathryn L Sarachan , Meghan C Johnson , Gregory D Van Duyne , A Gregory Matera   
Details Kushol Gupta et al; Nucleic Acids Res; 2021;
DOI 10.1093/nar/gkab508
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Jill Bouchard
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Jill Bouchard
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The authors also think this protein’s oligomerization is important for its localization to stress granules and Cajal bodies, so they’re probably currently working out those details.