BAG3 and BAG6 differentially affect the dynamics of stress granules by targeting distinct subsets of defective polypeptides released from ribosomes

Authors Laura Mediani , Veronica Galli , Arianna Dorotea Carrà , Ilaria Bigi , Jonathan Vinet , Massimo Ganassi , Francesco Antoniani , Tatiana Tiago , Marco Cimino , Daniel Mateju , Cristina Cereda , Orietta Pansarasa , Simon Alberti  , Jessica Mandrioli , Serena Carra 
DetailsLaura Mediani et al; Cell Stress Chaperones; 2020;
DOI10.1007/s12192-020-01141-w
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Jill Bouchard
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Jill Bouchard
Contributing editor, Condensates.com

It looks like not all misfolded proteins and chaperone complexes were created equal when it comes to aggregation propensity inside condensates. Understanding these subtleties will likely be key to therapeutic intervention.