CGG repeat RNA G-quadruplexes interact with FMRpolyG to cause neuronal dysfunction in fragile X-related tremor/ataxia syndrome

Authors Sefan Asamitsu , Yasushi Yabuki  , Susumu Ikenoshita  , Kosuke Kawakubo  , Moe Kawasaki  , Shingo Usuki , Yuji Nakayama , Kaori Adachi , Hiroyuki Kugoh  , Kazuhiro Ishii , Tohru Matsuura , Eiji Nanba , Hiroshi Sugiyama , Kohji Fukunaga , Norifumi Shioda  
Details Sefan Asamitsu et al; Sci Adv; 2021;
DOI 10.1126/sciadv.abd9440
Topics
Keywords
Source View on PubMed

1
Join the conversation

Create an Account or Sign In to comment.
1 Comment threads
0 Thread replies
1 Followers
 
Most reacted comment
Hottest comment thread
1 Comment authors
Jill Bouchard Recent comment authors
newest oldest most voted
Jill Bouchard
Editor
Jill Bouchard
Managing editor, Condensates.com

This protein phase separates, and the CGG99 RNA accelerates a liq-sol transition… not surprising that behavior is tied to neurodegeneration.