Compositional analysis of ALS-linked stress granule-like structures reveals factors and cellular pathways dysregulated by mutant FUS under stress

Authors Haiyan An, Gioana Litscher, Wenbin Wei, Naruaki Watanabe, Tadafumi Hashimoto, Takeshi Iwatsubo, Vladimir L. Buchman, Tatyana A. Shelkovnikova
Details BioRxiv. March 02, 2021.
DOI 10.1101/2021.03.02.433611
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Jill Bouchard
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Jill Bouchard
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I’m not surprised that pathological and physiological stress granules have very different proteomes. These differences may inform ways to selectively treat the bad ones.