Compositional analysis of ALS-linked stress granule-like structures reveals factors and cellular pathways dysregulated by mutant FUS under stress
Authors | Haiyan An, Gioana Litscher, Wenbin Wei, Naruaki Watanabe, Tadafumi Hashimoto, Takeshi Iwatsubo, Vladimir L. Buchman, Tatyana A. Shelkovnikova |
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Details | BioRxiv. March 02, 2021. |
DOI | 10.1101/2021.03.02.433611 |
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Source | View on BioRxiv |
I’m not surprised that pathological and physiological stress granules have very different proteomes. These differences may inform ways to selectively treat the bad ones.