Disordered region of cereblon is required for efficient degradation by proteolysis-targeting chimera

Authors Kim K,, Lee DH, Park S,, Jo SH,, Ku B, Park SG,, Park BC,, Jeon YU, Ahn S,, Kang CH,, Hwang D, Chae S, Ha JD, Kim S,, Hwang JY,, Kim JH,
Details Sci Rep. 2019 Dec 23;9(1):19654. doi: 10.1038/s41598-019-56177-5
DOI 10.1038/s41598-019-56177-5
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Jill Bouchard Recent comment authors
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Jill Bouchard
Jill Bouchard
Editor in Chief, Condensates.com

Interesting! Disordered regions made proteins more susceptible to PROTAC-induced degredation. Could this be useful for targetting IDPs in condensates?