Disordered region of cereblon is required for efficient degradation by proteolysis-targeting chimera
|Authors||Kim K,, Lee DH, Park S,, Jo SH,, Ku B, Park SG,, Park BC,, Jeon YU, Ahn S,, Kang CH,, Hwang D, Chae S, Ha JD, Kim S,, Hwang JY,, Kim JH,|
|Details||Sci Rep. 2019 Dec 23;9(1):19654. doi: 10.1038/s41598-019-56177-5|
|Source||View on PubMed|
Interesting! Disordered regions made proteins more susceptible to PROTAC-induced degredation. Could this be useful for targetting IDPs in condensates?