Disruption of Cellular Proteostasis by H1N1 Influenza A Virus Causes α-Synuclein Aggregation

Authors Rita Marreiros , Andreas Müller-Schiffmann , Svenja V Trossbach , Ingrid Prikulis , Sebastian Hänsch , Stefanie Weidtkamp-Peters , Ana Raquel Moreira , Shriya Sahu , Irina Soloviev , Suganya Selvarajah , Vishwanath R Lingappa , Carsten Korth 
Details Rita Marreiros et al; Proc Natl Acad Sci U S A; 2020
DOI 10.1073/pnas.1906466117
Source View on PubMed

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Jill Bouchard
Jill Bouchard
Editor in Chief, Condensates.com

It’s interesting that viral infection results in the aggregation of α-synuclein, but not of tau or TDP-43. And the anti-influenza drug prevented said aggregation. I bet there are some pearls of wisdom within.