FRET-based Tau seeding assay does not represent prion-like templated assembly of Tau filaments

Authors Senthilvelrajan Kaniyappan  , Katharina Tepper , Jacek Biernat , Ram Reddy Chandupatla , Sabrina Hübschmann , Stephan Irsen , Sandra Bicher , Christoph Klatt , Eva-Maria Mandelkow  , Eckhard Mandelkow  
DetailsSenthilvelrajan Kaniyappan et al; Mol Neurodegener; 2020;
DOI10.1186/s13024-020-00389-1
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Jill Bouchard
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Jill Bouchard
Contributing editor, Condensates.com

This study shows an important consideration for condensate studies: does the tag affect the solubility of the protein of interest?