Hypusination of Eif5a regulates cytoplasmic TDP-43 aggregation and accumulation in a stress-induced cellular model

Authors Shayna Smeltzer , Zainuddin Quadri , Abraian Miller , Frank Zamudio , Jordan Hunter , Nicholas J F Stewart , Sheba Saji , Daniel C Lee , Dale Chaput , Maj-Linda B Selenica 
DetailsShayna Smeltzer et al; Biochim Biophys Acta Mol Basis Dis; 2020;
DOI10.1016/j.bbadis.2020.165939
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Jill Bouchard
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Jill Bouchard
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ICYMI, hypusine is an uncommon PTM on lysine, which causes interesting interactions between this translation initiation factor and proteins involved in 2 condensates (both stress granules and the nuclear pore complex).