Karyopherin abnormalities in neurodegenerative proteinopathies

Authors Terouz Pasha , Anna Zatorska , Daulet Sharipov , Boris Rogelj  , Tibor Hortobágyi  , Frank Hirth 
Details Terouz Pasha et al; Brain; 2021;
DOI 10.1093/brain/awab201
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Jill Bouchard
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Jill Bouchard
Managing editor, Condensates.com

This review focuses on the complex interplay between the dual functions of karyopherins–they’re known for nuclear import/export, but they also act as chaperones of disease-related proteins that are prone to phase separate.