LRP1 Is a Master Regulator of Tau Uptake and Spread
| Authors | Jennifer N Rauch , Gabriel Luna , Elmer Guzman , Morgane Audouard , Collin Challis , Youssef E Sibih , Carolina Leshuk , Israel Hernandez , Susanne Wegmann , Bradley T Hyman , Viviana Gradinaru , Martin Kampmann , Kenneth S Kosik |
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| Details | Jennifer N Rauch et al; Nature; 2020 Apr; |
| DOI | 10.1038/s41586-020-2156-5 |
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| Source | View on PubMed |
Here’s some stellar work showing that LRP1 interacts w/ lysine residues in Tau, allowing Tau to spread to other neurons.