Polyelectrolyte interactions enable rapid association and dissociation in high-affinity disordered protein complexes

Authors Andrea Sottini , Alessandro Borgia  , Madeleine B Borgia  , Katrine Bugge , Daniel Nettels , Aritra Chowdhury , Pétur O Heidarsson  , Franziska Zosel  , Robert B Best , Birthe B Kragelund , Benjamin Schuler  
DetailsAndrea Sottini et al; Nat Commun; 2020;
DOI10.1038/s41467-020-18859-x
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Jill Bouchard
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Jill Bouchard
Contributing editor, Condensates.com

Here’s a note to anyone studying condensate-loving IDPs: when highly charged species are involved, concentration can drastically change the kinetics of interactions.