RNF8 Dysregulation and Down-regulation During HTLV-1 Infection Promote Genomic Instability in Adult T-Cell Leukemia

Authors Huijun Zhi , Xin Guo , Yik-Khuan Ho , Nagesh Pasupala , Hampus Alexander Anders Engstrom , Oliver John Semmes , Chou-Zen Giam 
Details Huijun Zhi et al; PLoS Pathog; 2020;
DOI 10.1371/journal.ppat.1008618
Source View on PubMed

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Jill Bouchard
Jill Bouchard
Editor in Chief, Condensates.com

Interesting stuff: These authors show that upon infection of a leukemia-linked retrovirus, important DNA repair enzymes get sequestered away in Tax speckle structures, which leads to further genomic instability in leukemia cells.