RNF8 Dysregulation and Down-regulation During HTLV-1 Infection Promote Genomic Instability in Adult T-Cell Leukemia
| Authors | Huijun Zhi , Xin Guo , Yik-Khuan Ho , Nagesh Pasupala , Hampus Alexander Anders Engstrom , Oliver John Semmes , Chou-Zen Giam |
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| Details | Huijun Zhi et al; PLoS Pathog; 2020; |
| DOI | 10.1371/journal.ppat.1008618 |
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| Source | View on PubMed |
Interesting stuff: These authors show that upon infection of a leukemia-linked retrovirus, important DNA repair enzymes get sequestered away in Tax speckle structures, which leads to further genomic instability in leukemia cells.