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Signalling mechanisms and cellular functions of SUMO

Authors Alfred C O Vertegaal 
Details Alfred C O Vertegaal; Nat Rev Mol Cell Biol; 2022;
DOI 10.1038/s41580-022-00500-y
Source View on PubMed

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Sidharth Sirdeshmukh Recent comment authors
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Sidharth Sirdeshmukh
Sidharth Sirdeshmukh
Research Associate, Dewpoint

Sumoylation is a post-translational modification that organizes and coordinates systematic processes within cells. One of these processes that people are interested in is targeted protein degradation. E3 ligases are ultimately responsible for depositing SUMO proteins onto target proteins, and scientists are hoping that the process of identifying sumoylated proteins (target proteins), and then tuning SUMO deposition will enable programmed upregulation and downregulation of these targets to conquer disease. Because sumoylation (and ubiquitinoylation) is reversible, the goal would be to somehow sustain this phenotype. However, it’s probably more nuanced than this- there is likely a threshold within the SUMO-cycle that needs… Read more »