Synaptic accumulation of FUS triggers age-dependent misregulation of inhibitory synapses in ALS-FUS mice

Authors Sonu Sahadevan, Katharina M Hembach, Elena Tantardini, Manuela Perez-Berlanga, Marian Hruska-Plochan, Julien Weber, Petra Schwarz, Luc Dupuis, Mark D. Robinson, Pierre De Rossi, Magdalini Polymenidou
DetailsBioRxiv. Posted June 10, 2020.
DOI10.1101/2020.06.10.136010
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Jill Bouchard Recent comment authors
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Jill Bouchard
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Jill Bouchard
Contributing editor, Condensates.com

It looks like the main problem is the localization of FUS at the synapse and the RNA it brings with it. I wonder if phase separation is at play here?