Must Read

The Mediator complex as a master regulator of transcription by RNA polymerase II

Authors William F Richter, Shraddha Nayak, Janet Iwasa, Dylan J Taatjes
Details William F Richter et al; Nat Rev Mol Cell Biol; 2022
DOI 10.1038/s41580-022-00498-3
Source View on PubMed

Join the conversation

Create an Account or Sign In to comment.
1 Comment threads
0 Thread replies
Most reacted comment
Hottest comment thread
1 Comment authors
Sidharth Sirdeshmukh Recent comment authors
newest oldest most voted
Sidharth Sirdeshmukh
Sidharth Sirdeshmukh
Research Associate, Dewpoint

The Mediator complex is basically a central regulator/ coordinating scaffold for enhancers that beckons Pol II to transcribe DNA to RNA, but doesn’t bind to DNA itself. I think of it as a rotating log that floats around, but doesn’t touch the DNA. This log has peg holes, and the peg holes can change size and position, leaving room for various enhancers (the pegs). The size and position of the peg holes will continue to change as new enhancers bind. When the peg holes are filled ‘favorably’ then Pol II is finally recruited to the DNA, initiating transcription. This review… Read more »