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Unblending of Transcriptional Condensates in Human Repeat Expansion Disease

Authors Shaon Basu , Sebastian D Mackowiak , Henri Niskanen , Dora Knezevic , Vahid Asimi , Stefanie Grosswendt , Hylkje Geertsema , Salaheddine Ali , Ivana Jerković , Helge Ewers , Stefan Mundlos , Alexander Meissner , Daniel M Ibrahim , Denes Hnisz 
DetailsShaon Basu et al; Cell; 2020;
DOI10.1016/j.cell.2020.04.018
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Jill Bouchard
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Jill Bouchard
Contributing editor, Condensates.com

It’s not surprising that repeat expansions alter the phase separation and subsequent material properties of condensates. The discussion on how poly-alanine (and other IDR) tracts contribute to disease will be super useful going forward.