Adapted from Patel A, et al, Front Mol Biosci (2022)
A condensate modifying drug, also referred to as condensate modulator (c-mod), is a molecule that modifies the properties of a biomolecular condensate (refer to Glossary for condensate science terminology). The c-mod encyclopedia is a literature-based, semi-manually curated list of tool compounds and clinically-validated drugs, with experimental evidence of condensate modulating mechanism of action. The denoted phenotypic class is relative to the condensate marker(s) utilized in the respective cited study. While the deliberate discovery and development of c-mods is in its early stages, many FDA-approved drugs are now retrospectively understood to function, at least in part, through condensate-mediated mechanisms.
NEW! The c-mod encyclopedia is now integrated in CD-CODE and cross-referenced with other external large databases, including UniProt, ChEMBL, PubChem and Disease Ontology.
Curator in residence: Allysa P. Kemraj
The legacy c-mods table below will be retired at the end of the year.
Last updated on October 16, 2025 | N = 591
* A drug is marked “Yes” if it is approved by a Competent Health Authority (e.g., FDA in the US) in at least one Territory/Region, for human and/or veterinary use.”
Approval status and canonical target are based on https://drugs.ncats.io/
| C-mod | *Approved? | Target condensate | Condensate marker(s) | Target molecule | Phenotypic class | Modality | Reference | ||
|---|---|---|---|---|---|---|---|---|---|
| KB2 | No | Stress granules | G3BP1 | unknown | Inducer | fragment | COVID | https://pubmed.ncbi.nlm.nih.gov/38014036/ | |
| KB20 | No | Stress granules | G3BP1 | unknown | Inducer | fragment | COVID | https://pubmed.ncbi.nlm.nih.gov/38014036/ | |
| KB23 | No | Stress granules | G3BP1 | unknown | Inducer | fragment | COVID | https://pubmed.ncbi.nlm.nih.gov/38014036/ | |
| KB5 | No | Stress granules | G3BP1 | unknown | Inducer | fragment | COVID | https://pubmed.ncbi.nlm.nih.gov/38014036/ | |
| KB7 | No | Stress granules | G3BP1 | unknown | Inducer | fragment | COVID | https://pubmed.ncbi.nlm.nih.gov/38014036/ | |
| (-)-Epigallocatechin-3-gallate | EGCG | No | Tau condensates | Tau | Tau | Inducer | natural product | Alzheimer's disease | https://pubmed.ncbi.nlm.nih.gov/36688583/ |
| (-)-Gallocatechin gallate | GCG | No | SARS-CoV-2 nucleocapsid condensates | SARS-Co-V2 nucleocapsid | Bcl-2; HIV-1 integrase | Dissolver | natural product | COVID | https://pubmed.ncbi.nlm.nih.gov/33837182/ |
| 5z-7-oxozeaenol | No | INAVA condensates | INAVA | TAK1 | Inducer | natural product | inflammatory bowel disease (IBD) | https://pubmed.ncbi.nlm.nih.gov/34251416/ | |
| Curcumin | No | α-Synuclein in vitro condensates | α-Synuclein | unknown | Morpher | natural product | Parkinson's disease | https://pubmed.ncbi.nlm.nih.gov/36061735/ | |
| Green Tea Polyphenols (GTP) | No | Insulin fibrils | Insulin | Insulin | Dissolver | natural product | neurodegeneration | https://pubmed.ncbi.nlm.nih.gov/38365968/ | |
| Green Tea Polyphenols (GTP) | No | α-synuclein fibrils | α-synuclein | α-synuclein | Dissolver | natural product | neurodegeneration | https://pubmed.ncbi.nlm.nih.gov/38365968/ | |
| Myricetin | No | Tau in vitro condensate, stress granules | Tau, G3BP1 | unknown | Dissolver | natural product | Alzheimer's disease | https://pubmed.ncbi.nlm.nih.gov/34560101/ | |
| Nobiletin | No | Stress granules | G3BP1, TIA1 | unknown | Dissolver | natural product | neurodegeneration | https://pubmed.ncbi.nlm.nih.gov/35631419/ | |
| Pateamine A | No | Stress granules | TIAR, G3BP1 | eIF4A | Inducer | natural product | influenza A virus (IAV) | https://pubmed.ncbi.nlm.nih.gov/29258238/ | |
| PCG | No | Transcriptional condensates | BRD4 | BRD4 | Inducer | natural product | https://pubmed.ncbi.nlm.nih.gov/35072011/ | ||
| Silvestrol | No | Stress granules | TIAR, G3BP1 | eIF4A | Inducer | natural product | influenza A virus (IAV) | https://pubmed.ncbi.nlm.nih.gov/29258238/ | |
| Triptolide | No | Stress granules | G3BP1, TIA1 | unknown | Dissolver | natural product | https://pubmed.ncbi.nlm.nih.gov/38366783/ | ||
| ASO-CCG | No | (CGG)100 RNA foci | (CGG)100 RNA | CGG RNA repeats | Dissolver | oligonucleotide | Fragile X-associated tremor/ataxia syndrome (FXTAS) | https://pubmed.ncbi.nlm.nih.gov/33627639/ | |
| c9ASO | No | C9ORF72 expansion bodies | (G4C2)149 RNA foci | C9ORF72 | Dissolver | oligonucleotide | amyotrophic lateral sclerosis (ALS)/frontotemporal dementia (FTD) | https://pubmed.ncbi.nlm.nih.gov/32878979/ | |
| ION363 | No | FUS aggregates | mutant FUS | FUS transcript | Dissolver | oligonucleotide | amyotrophic lateral sclerosis (ALS) | https://pubmed.ncbi.nlm.nih.gov/35075293/ | |
| Nusinersen | Yes | Cajal Body | Coilin, SMN | SMA | Inducer | oligonucleotide | Spinal muscular atrophy (SMA) | https://pubmed.ncbi.nlm.nih.gov/32612161/ | |
| cb-N-Apt17 | No | SARS-CoV-2 Nucleocapsid condensates, Nucleocapsid in vitro reconstituted condensates | SARS-CoV-2 N protein | SARS-CoV-2 N protein | Dissolver | oligonucleotide | COVID | https://pubmed.ncbi.nlm.nih.gov/38376366/ | |
| Guanosine 12-mer | No | SARS-CoV-2 nucleocapsid + viral RNA probe in vitro condensates | SARS-CoV-2 Nucleocapsid | SARS-CoV-2 Nucleocapsid | Localizer | oligonucleotide | COVID | https://pubmed.ncbi.nlm.nih.gov/36748338/ | |
| cDex | No | RNA condensates | RNA | RNA | Inducer | other | cancer | https://pubmed.ncbi.nlm.nih.gov/36209170/ | |
| DETA-Dex | No | RNA condensates | RNA | RNA | Inducer | other | cancer | https://pubmed.ncbi.nlm.nih.gov/36209170/ | |
| PEI | No | RNA condensates | RNA | RNA | Inducer | other | cancer | https://pubmed.ncbi.nlm.nih.gov/36209170/ | |
| NU7441 + CLM | No | Stress granules | G3BP1, FUS | DNA-PK + DNA | Localizer | other | https://pubmed.ncbi.nlm.nih.gov/33857636/ | ||
| GQDs-Cl | No | TDP-43 in vitro reconstituted condensate; TDP-43 nuclear bodies; stress granules | TDP-43 or mutant TDP-43 | TDP-43 | Dissolver | other | amyotrophic lateral sclerosis (ALS) | https://pubmed.ncbi.nlm.nih.gov/38582774/ | |
| Cl-GQDs-OH | No | TDP-43 in vitro reconstituted condensate; TDP-43 nuclear bodies; stress granules | TDP-43 or mutant TDP-43 | TDP-44 | Dissolver | other | amyotrophic lateral sclerosis (ALS) | https://pubmed.ncbi.nlm.nih.gov/38582774/ | |
| Green Tea Polyphenols (GTP)-capped AgNPs | No | Insulin fibrils | Insulin | Insulin | Dissolver | other | neurodegeneration | https://pubmed.ncbi.nlm.nih.gov/38365968/ | |
| Green Tea Polyphenols (GTP)-capped AgNPs | No | α-synuclein fibrils | α-synuclein | α-synuclein | Dissolver | other | neurodegeneration | https://pubmed.ncbi.nlm.nih.gov/38365968/ | |
| a-amanitin | No | Nucleolus | FUS | RNA polymerase | Localizer | peptide | https://pubmed.ncbi.nlm.nih.gov/34380923/ | ||
| a-amanitin | No | Stress granules | G3BP1, TIA1 | RNA Pol II | Dissolver | peptide | https://pubmed.ncbi.nlm.nih.gov/38366783/ | ||
| BiTud | No | Stress granules, G3BP1-TDRD3-RNA in vitro reconstituted condensates | G3BP1, TDRD3 | TDRD3 | Dissolver | peptide | cancer, drug resistance | https://pubmed.ncbi.nlm.nih.gov/38126399/ | |
| CrACP1 | No | SARS-Co-V2 Nucleocapsid in vitro reconstituted condensates | N protein | SARS-CoV-2 N protein | Morpher | peptide | COVID | https://pubmed.ncbi.nlm.nih.gov/38483823/ | |
| GKY20 | No | SARS-Co-V2 Nucleocapsid in vitro reconstituted condensates | N protein | N protein | Morpher | peptide | COVID | https://pubmed.ncbi.nlm.nih.gov/38483823/ | |
| LL-III | No | SARS-Co-V2 Nucleocapsid in vitro reconstituted condensates | N protein | N protein | Morpher | peptide | COVID | https://pubmed.ncbi.nlm.nih.gov/38483823/ | |
| NSIP-III | No | SARS-CoV-2 nucleocapsid condensates | SARS-CoV-2 Nucleocapsid | TRIM28/SARS-CoV-2 Nucleocapsid | Dissolver | peptide | COVID | https://pubmed.ncbi.nlm.nih.gov/38172120/ | |
| P22 | No | SARS-CoV-2 Nucleoprotein fibrils | Nucleoprotein | Nucleoprotein | Dissolver | peptide | COVID | https://www.biorxiv.org/content/10.1101/2021.03.05.434000v2 | |
| P29 | No | SARS-CoV-2 Nucleoprotein fibrils | Nucleoprotein | Nucleoprotein | Dissolver | peptide | COVID | https://www.biorxiv.org/content/10.1101/2021.03.05.434000v2 | |
| S17 | No | SARS-CoV-2 Nucleoprotein fibrils | Nucleoprotein | Nucleoprotein | Dissolver | peptide | COVID | https://www.biorxiv.org/content/10.1101/2021.03.05.434000v2 | |
| S18 | No | SARS-CoV-2 Nucleoprotein fibrils | Nucleoprotein | Nucleoprotein | Dissolver | peptide | COVID | https://www.biorxiv.org/content/10.1101/2021.03.05.434000v2 | |
| ADH-6 | No | p53 mutant aggregates | p53 mutant | p53 | Dissolver | peptide | cancer | https://pubmed.ncbi.nlm.nih.gov/34172723/ | |
| AVLX-144 | No | PSD95 in vitro condensates | PSD95 | PSD95 | Inducer | peptide | https://pubmed.ncbi.nlm.nih.gov/35198873/ | ||
| Nerinetide | NA-1 | No | PSD95 in vitro condensates | PSD95 | PSD95 | Inducer | peptide | ischemic stroke | https://pubmed.ncbi.nlm.nih.gov/35198873/ |
| Nerinetide | NA-1 | No | ePSD in vitro condensates | PSD95, Shank3 | PSD95 | Inducer | peptide | ischemic stroke | https://pubmed.ncbi.nlm.nih.gov/35198873/ |
| NIP-V | No | SARS-CoV-2 Nucleocapsid and RNA in vitro reconstituted condensates|SARS-CoV-2 Nucleocapsid condensates | SARS-CoV-2 Nucleocapsid | SARS-CoV-2 Nucleocapsid | Dissolver | peptide | COVID | https://pubmed.ncbi.nlm.nih.gov/34239064/ | |
| Streptavidin | SA | No | Streptavidin/ACC1 cytosolic condensates | ACC1, Streptavidin | ACC1 | Localizer | protein | nonalcoholic steatohepatitis | https://pubmed.ncbi.nlm.nih.gov/37976162/ |
| UT-143 | No | Androgen receptor foci | Androgen receptor splice variants | Androgen receptor | Dissolver | small molecule | prostate cancer | https://pubmed.ncbi.nlm.nih.gov/36577061/ | |
| 17-Allylamino-geldanamycin | No | INAVA condensates | INAVA | HSP90 | Inducer | small molecule | inflammatory bowel disease (IBD) | https://pubmed.ncbi.nlm.nih.gov/34251416/ | |
| 5z-7-oxozeaenol | No | IL-1b-induced INAVA condensates | INAVA | TAK1 | Dissolver | small molecule | inflammatory bowel disease (IBD) | https://pubmed.ncbi.nlm.nih.gov/34251416/ | |
| Acepromazine | Yes | multimeric proteins (such as in condensates) to the NPC | NUP98 | TRIM21 | Localizer | small molecule | neurodegeneration, autoimmunity, cancer | https://www.biorxiv.org/content/10.1101/2024.01.31.578122v1 | |
| Actinomycin D | Yes | Stress granules | G3BP1, TIA1 | DNA | Dissolver | small molecule | https://pubmed.ncbi.nlm.nih.gov/38366783/ | ||
| ADP-heptose | No | TIFA condensates | TIFA|TRAF6 | ALPK1 | Inducer | small molecule | https://pubmed.ncbi.nlm.nih.gov/38357697/ | ||
| Afatinib | Yes | Stress granules | G3BP1 | mTORC1 | Inducer | small molecule | COVID | https://pubmed.ncbi.nlm.nih.gov/38014036/ | |
| Albendazole | Yes | INAVA condensates | INAVA | Tubulin | Inducer | small molecule | inflammatory bowel disease (IBD) | https://pubmed.ncbi.nlm.nih.gov/34251416/ | |
| AMG-47a | No | IL-1b-induced INAVA condensates | INAVA | LCK | Dissolver | small molecule | inflammatory bowel disease (IBD) | https://pubmed.ncbi.nlm.nih.gov/34251416/ | |
| AMG-Tie2-1 | No | IL-1b-induced INAVA condensates | INAVA | Tie-2 | Dissolver | small molecule | inflammatory bowel disease (IBD) | https://pubmed.ncbi.nlm.nih.gov/34251416/ | |
| Anisomycin | No | IL-1b-induced INAVA condensates | INAVA | Protein synthesis | Dissolver | small molecule | inflammatory bowel disease (IBD) | https://pubmed.ncbi.nlm.nih.gov/34251416/ | |
| AS-605240 | No | Paraspeckles | NEAT1_2 | PI3K | Dissolver | small molecule | https://pubmed.ncbi.nlm.nih.gov/36099417/ | ||
| Auranofin | Yes | INAVA condensates | INAVA | Mitochondrial thioredoxin reductase | Inducer | small molecule | inflammatory bowel disease (IBD) | https://pubmed.ncbi.nlm.nih.gov/34251416/ | |
| Auranofin | Yes | Stress granules | G3BP1 | TXNRD1/2 | Inducer | small molecule | COVID | https://pubmed.ncbi.nlm.nih.gov/38014036/ | |
| AV-412 | No | INAVA condensates | INAVA | EFGR/HER2 | Inducer | small molecule | inflammatory bowel disease (IBD) | https://pubmed.ncbi.nlm.nih.gov/34251416/ | |
| AV951 | No | IL-1b-induced INAVA condensates | INAVA | VEGF receptor | Dissolver | small molecule | inflammatory bowel disease (IBD) | https://pubmed.ncbi.nlm.nih.gov/34251416/ | |
| BAPTA-AM | No | INAVA condensates | INAVA | Ca2+ chleator | Inducer | small molecule | inflammatory bowel disease (IBD) | https://pubmed.ncbi.nlm.nih.gov/34251416/ | |
| Berberine chloride | No | Stress granules | FUS, G3BP1, Fibrillarin | AMPK | Localizer | small molecule | https://pubmed.ncbi.nlm.nih.gov/36606141/ | ||
| Beta-lapachone | No | INAVA condensates | INAVA | Topoisomerase | Inducer | small molecule | inflammatory bowel disease (IBD) | https://pubmed.ncbi.nlm.nih.gov/34251416/ | |
| BEZ235 | No | IL-1b-induced INAVA condensates | INAVA | mTOR | Dissolver | small molecule | inflammatory bowel disease (IBD) | https://pubmed.ncbi.nlm.nih.gov/34251416/ | |
| Bleomycin | Yes | DNA damage foci | g-H2AX | DNA | Inducer | small molecule | https://pubmed.ncbi.nlm.nih.gov/34306316/ | ||
| Bortezomib | Yes | INAVA condensates | INAVA | Proteasome | Inducer | small molecule | inflammatory bowel disease (IBD) | https://pubmed.ncbi.nlm.nih.gov/34251416/ | |
| BX795 | No | IL-1b-induced INAVA condensates | INAVA | TBK1/PDK | Dissolver | small molecule | inflammatory bowel disease (IBD) | https://pubmed.ncbi.nlm.nih.gov/34251416/ | |
| Calicheamicin | CLM | Yes | Stress granules | G3BP1 | DNA | Inducer | small molecule | https://pubmed.ncbi.nlm.nih.gov/33857636/ | |
| Carbon monoxide-releasing molecular-A1 | CORM-A1 | No | DNA damage foci | g-H2AX | Integrated stress response (ISR) | Dissolver | small molecule | https://pubmed.ncbi.nlm.nih.gov/34306316/ | |
| Carbon monoxide-releasing molecular-A1 | CORM-A1 | No | Stress granules | TIA1, G3BP1, PAI1 | Integrated stress response (ISR) | Inducer | small molecule | https://pubmed.ncbi.nlm.nih.gov/34306316/ | |
| Cycloheximide | No | IL-1b-induced INAVA condensates | INAVA | Protein synthesis | Dissolver | small molecule | inflammatory bowel disease (IBD) | https://pubmed.ncbi.nlm.nih.gov/34251416/ | |
| Cyclopamine | CPM | No | Viral factories, in vitro reconstituted viral condensates | RSV Phosphoprotein| RSV Nucleoprotein| RSV M2-1 | M2-1 | Morpher | small molecule | respiratory syncytial virus (RSV) | https://pubmed.ncbi.nlm.nih.gov/34234347/ |
| A3E | No | Viral factories, in vitro reconstituted viral condensates | RSV Phosphoprotein| RSV Nucleoprotein| RSV M2-1 | M2-1 | Morpher | small molecule | respiratory syncytial virus (RSV) | https://pubmed.ncbi.nlm.nih.gov/34234347/ | |
| Cytochalasin D | No | INAVA condensates | INAVA | Actin | Inducer | small molecule | inflammatory bowel disease (IBD) | https://pubmed.ncbi.nlm.nih.gov/34251416/ | |
| Dasatinib | Yes | Paraspeckles | NEAT1_2 | ABL | Dissolver | small molecule | https://pubmed.ncbi.nlm.nih.gov/36099417/ | ||
| DCC-2036 | No | IL-1b-induced INAVA condensates | INAVA | Bcr-Abl kinase/TIE/VEGF receptor | Dissolver | small molecule | inflammatory bowel disease (IBD) | https://pubmed.ncbi.nlm.nih.gov/34251416/ | |
| Emetine | Yes | IL-1b-induced INAVA condensates | INAVA | Protein synthesis | Dissolver | small molecule | inflammatory bowel disease (IBD) | https://pubmed.ncbi.nlm.nih.gov/34251416/ | |
| EN450 | No | Stress granules | G3BP1 | E2 ubiquitin-conjugating enzyme | Inducer | small molecule | COVID | https://pubmed.ncbi.nlm.nih.gov/38014036/ | |
| ET070 | No | mutant SHP2 condensates | mutant SHP2 | SHP2 | Dissolver | small molecule | SHP2‒associated cancers | https://pubmed.ncbi.nlm.nih.gov/38451719/ | |
| Fascaplysin | No | INAVA condensates | INAVA | Cdk | Inducer | small molecule | inflammatory bowel disease (IBD) | https://pubmed.ncbi.nlm.nih.gov/34251416/ | |
| Flagellin | No | TIFA condensates | TRAF6|TIFA | TLR5 | Inducer | small molecule | https://pubmed.ncbi.nlm.nih.gov/38357697/ | ||
| Furoxan | No | INAVA condensates | INAVA | ROS | Inducer | small molecule | inflammatory bowel disease (IBD) | https://pubmed.ncbi.nlm.nih.gov/34251416/ | |
| Ganetespib | No | INAVA condensates | INAVA | HSP90 | Inducer | small molecule | inflammatory bowel disease (IBD) | https://pubmed.ncbi.nlm.nih.gov/34251416/ | |
| GDC-0980 | No | IL-1b-induced INAVA condensates | INAVA | mTOR | Dissolver | small molecule | inflammatory bowel disease (IBD) | https://pubmed.ncbi.nlm.nih.gov/34251416/ | |
| Geldanamycin | GA | No | INAVA condensates | INAVA | HSP90 | Inducer | small molecule | inflammatory bowel disease (IBD) | https://pubmed.ncbi.nlm.nih.gov/34251416/ |
| GNE-493 | No | IL-1b-induced INAVA condensates | INAVA | mTOR | Dissolver | small molecule | inflammatory bowel disease (IBD) | https://pubmed.ncbi.nlm.nih.gov/34251416/ | |
| Gramicidin | Yes | INAVA condensates | INAVA | Antibacterial | Inducer | small molecule | inflammatory bowel disease (IBD) | https://pubmed.ncbi.nlm.nih.gov/34251416/ | |
| GSK2879552 | No | Superenhancer condensates | BRD4 | LSD1 | Dissolver | small molecule | castration-resistant prostate cancer | https://pubmed.ncbi.nlm.nih.gov/36877164/ | |
| GSK626616 | No | Stress granules | G3BP2 | DYRK3 | Inducer | small molecule | https://pubmed.ncbi.nlm.nih.gov/33738926/ | ||
| GSK626616 | No | Nuclear speckles | SC35, DYRK3 | DYRK3 | Localizer | small molecule | https://pubmed.ncbi.nlm.nih.gov/33738926/ | ||
| GTPL6019 | No | IL-1b-induced INAVA condensates | INAVA | PDGF receptor tyrosine kinase | Dissolver | small molecule | inflammatory bowel disease (IBD) | https://pubmed.ncbi.nlm.nih.gov/34251416/ | |
| GW856553X | No | IL-1b-induced INAVA condensates | INAVA | p38 MAPK | Dissolver | small molecule | inflammatory bowel disease (IBD) | https://pubmed.ncbi.nlm.nih.gov/34251416/ | |
| Herbimycin A | No | INAVA condensates | INAVA | Tyrosine kinase | Inducer | small molecule | inflammatory bowel disease (IBD) | https://pubmed.ncbi.nlm.nih.gov/34251416/ | |
| Ibrutinib | Yes | Stress granules | G3BP1 | Btk | Inducer | small molecule | COVID | https://pubmed.ncbi.nlm.nih.gov/38014036/ | |
| Icaritin | ICA | No | Stress granules | G3BP1, IKKa mRNA | NF-kB, IL6 | Dissolver | small molecule | concurrent intrahepatic cholangiocarcinoma (ICC) and hepatolithiasis | https://pubmed.ncbi.nlm.nih.gov/38368261/ |
| IKK inhibitor VII | No | IL-1b-induced INAVA condensates | INAVA | IKK | Dissolver | small molecule | inflammatory bowel disease (IBD) | https://pubmed.ncbi.nlm.nih.gov/34251416/ | |
| IKK-2 inhibitor IV | No | IL-1b-induced INAVA condensates | INAVA | IKK-2 | Dissolver | small molecule | inflammatory bowel disease (IBD) | https://pubmed.ncbi.nlm.nih.gov/34251416/ | |
| IKK-2 inhibitor VI | No | IL-1b-induced INAVA condensates | INAVA | IKK-2 | Dissolver | small molecule | inflammatory bowel disease (IBD) | https://pubmed.ncbi.nlm.nih.gov/34251416/ | |
| IKK-2 inhibitor XI | No | IL-1b-induced INAVA condensates | INAVA | IKK-2 | Dissolver | small molecule | inflammatory bowel disease (IBD) | https://pubmed.ncbi.nlm.nih.gov/34251416/ | |
| IL-1b | No | TIFA condensates | TRAF6|TIFA | IL-1R | Inducer | protein | https://pubmed.ncbi.nlm.nih.gov/38357697/ | ||
| INK128 | No | Stress granules | G3BP1 | mTOR | Dissolver | small molecule | https://pubmed.ncbi.nlm.nih.gov/36099417/ | ||
| INK-128 | No | IL-1b-induced INAVA condensates | INAVA | mTOR | Dissolver | small molecule | inflammatory bowel disease (IBD) | https://pubmed.ncbi.nlm.nih.gov/34251416/ | |
| Isoginkgetin | No | Stress granules | G3BP1, TIA1 | SF3B1 | Dissolver | small molecule | https://pubmed.ncbi.nlm.nih.gov/38366783/ | ||
| JC19 | No | Stress granules | G3BP1 | nsp14 | Inducer | small molecule | COVID | https://pubmed.ncbi.nlm.nih.gov/38014036/ | |
| K-252a | No | IL-1b-induced INAVA condensates | INAVA | PKA/C/G | Dissolver | small molecule | inflammatory bowel disease (IBD) | https://pubmed.ncbi.nlm.nih.gov/34251416/ | |
| KU0063794 | No | IL-1b-induced INAVA condensates | INAVA | mTOR | Dissolver | small molecule | inflammatory bowel disease (IBD) | https://pubmed.ncbi.nlm.nih.gov/34251416/ | |
| KW-2449 | No | IL-1b-induced INAVA condensates | INAVA | FLT3 | Dissolver | small molecule | inflammatory bowel disease (IBD) | https://pubmed.ncbi.nlm.nih.gov/34251416/ | |
| KX01 | No | INAVA condensates | INAVA | Tubulin | Inducer | small molecule | inflammatory bowel disease (IBD) | https://pubmed.ncbi.nlm.nih.gov/34251416/ | |
| Latrunculin B | No | INAVA condensates | INAVA | Actin | Inducer | small molecule | inflammatory bowel disease (IBD) | https://pubmed.ncbi.nlm.nih.gov/34251416/ | |
| LPS | No | TIFA condensates | TRAF6|TIFA | TLR1/1 | Inducer | small molecule | https://pubmed.ncbi.nlm.nih.gov/38357697/ | ||
| LY2228820 | No | IL-1b-induced INAVA condensates | INAVA | p38 MAPK | Dissolver | small molecule | inflammatory bowel disease (IBD) | https://pubmed.ncbi.nlm.nih.gov/34251416/ | |
| LY3023414 | No | Paraspeckles | NEAT1_2 | PI3K/mTOR/DNA-PK | Dissolver | small molecule | https://pubmed.ncbi.nlm.nih.gov/36099417/ | ||
| LY-83583 | No | INAVA condensates | INAVA | ROS | Inducer | small molecule | inflammatory bowel disease (IBD) | https://pubmed.ncbi.nlm.nih.gov/34251416/ | |
| Lycorine | No | IL-1b-induced INAVA condensates | INAVA | Protein synthesis | Dissolver | small molecule | inflammatory bowel disease (IBD) | https://pubmed.ncbi.nlm.nih.gov/34251416/ | |
| Methylene blue | Yes | Tau in vitro condensates | Tau | Tau | Inducer | small molecule | https://pubmed.ncbi.nlm.nih.gov/37673952/ | ||
| MG132 | No | Stress granules | TIA1 | Proteosome | Inducer | small molecule | https://pubmed.ncbi.nlm.nih.gov/27570075/ | ||
| MG132 | No | INAVA condensates | INAVA | Proteasome | Inducer | small molecule | inflammatory bowel disease (IBD) | https://pubmed.ncbi.nlm.nih.gov/34251416/ | |
| MG132 | No | Stress granules | UBP1b, TZF1 | Proteosome | Localizer | small molecule | https://www.biorxiv.org/content/10.1101/2024.02.20.581253v1 | ||
| NB001 | No | Stress granules | G3BP1 | nsp14 | Inducer | small molecule | COVID | https://pubmed.ncbi.nlm.nih.gov/38014036/ | |
| NG25 | No | IL-1b-induced INAVA condensates | INAVA | mulitple kinases | Dissolver | small molecule | inflammatory bowel disease (IBD) | https://pubmed.ncbi.nlm.nih.gov/34251416/ | |
| NS-1619 | No | INAVA condensates | INAVA | K-channel | Inducer | small molecule | inflammatory bowel disease (IBD) | https://pubmed.ncbi.nlm.nih.gov/34251416/ | |
| NVP-AUY922 | No | INAVA condensates | INAVA | HSP90 | Inducer | small molecule | inflammatory bowel disease (IBD) | https://pubmed.ncbi.nlm.nih.gov/34251416/ | |
| NVP-BHG712 | No | IL-1b-induced INAVA condensates | INAVA | EPHB4 | Dissolver | small molecule | inflammatory bowel disease (IBD) | https://pubmed.ncbi.nlm.nih.gov/34251416/ | |
| ODN | No | TIFA condensates | TRAF6|TIFA | TLR9 | Inducer | small molecule | https://pubmed.ncbi.nlm.nih.gov/38357697/ | ||
| OTSSP167 | No | IL-1b-induced INAVA condensates | INAVA | MELK | Dissolver | small molecule | inflammatory bowel disease (IBD) | https://pubmed.ncbi.nlm.nih.gov/34251416/ | |
| Oxibendazole | Yes | INAVA condensates | INAVA | Tubulin | Inducer | small molecule | inflammatory bowel disease (IBD) | https://pubmed.ncbi.nlm.nih.gov/34251416/ | |
| p38 MAPK inhibitor VIII | No | IL-1b-induced INAVA condensates | INAVA | p38 MAPK | Dissolver | small molecule | inflammatory bowel disease (IBD) | https://pubmed.ncbi.nlm.nih.gov/34251416/ | |
| Paclitaxel | Yes | Stress granules | TIA1 | Tubulin | Inducer | small molecule | triple negative breast cancer (TNBC), drug resistance | https://pubmed.ncbi.nlm.nih.gov/34857678/ | |
| Pam2CSK4 | No | TIFA condensates | TRAF6|TIFA | TLR1/2 | Inducer | small molecule | https://pubmed.ncbi.nlm.nih.gov/38357697/ | ||
| Parthenolide | Yes | INAVA condensates | INAVA | Sesquiterpene lactone | Inducer | small molecule | inflammatory bowel disease (IBD) | https://pubmed.ncbi.nlm.nih.gov/34251416/ | |
| PD 169316 | No | IL-1b-induced INAVA condensates | INAVA | p38 MAPK | Dissolver | small molecule | inflammatory bowel disease (IBD) | https://pubmed.ncbi.nlm.nih.gov/34251416/ | |
| PDGF receptor tyrosine kinase inhibitor III | No | IL-1b-induced INAVA condensates | INAVA | PDGF receptor tyrosine kinase | Dissolver | small molecule | inflammatory bowel disease (IBD) | https://pubmed.ncbi.nlm.nih.gov/34251416/ | |
| PH-797804 | No | IL-1b-induced INAVA condensates | INAVA | p38 MAPK | Dissolver | small molecule | inflammatory bowel disease (IBD) | https://pubmed.ncbi.nlm.nih.gov/34251416/ | |
| PI-103 | No | IL-1b-induced INAVA condensates | INAVA | mTOR | Dissolver | small molecule | inflammatory bowel disease (IBD) | https://pubmed.ncbi.nlm.nih.gov/34251416/ | |
| PI-103 | No | Paraspeckles | NEAT1_2 | PI3K/mTOR/DNA-PK | Dissolver | small molecule | https://pubmed.ncbi.nlm.nih.gov/36099417/ | ||
| PI-3Kα inhibitor IV | No | IL-1b-induced INAVA condensates | INAVA | mTOR | Dissolver | small molecule | inflammatory bowel disease (IBD) | https://pubmed.ncbi.nlm.nih.gov/34251416/ | |
| PIK-75 | No | Paraspeckles | NEAT1_2 | PI3K | Dissolver | small molecule | https://pubmed.ncbi.nlm.nih.gov/36099417/ | ||
| PIK-75 | No | Stress granules | G3BP1 | PI3K | Dissolver | small molecule | https://pubmed.ncbi.nlm.nih.gov/36099417/ | ||
| PLB | No | Stress granules | G3BP1, TIA1 | SF3B1 | Dissolver | small molecule | https://pubmed.ncbi.nlm.nih.gov/38366783/ | ||
| PP242 | No | Paraspeckles | NEAT1_2 | mTOR | Dissolver | small molecule | https://pubmed.ncbi.nlm.nih.gov/36099417/ | ||
| PP242 | No | Stress granules | G3BP1 | mTOR | Dissolver | small molecule | https://pubmed.ncbi.nlm.nih.gov/36099417/ | ||
| R848 | No | TIFA condensates | TRAF6|TIFA | TLR7/8 | Inducer | small molecule | https://pubmed.ncbi.nlm.nih.gov/38357697/ | ||
| Radicicol | No | INAVA condensates | INAVA | HSP90 | Inducer | small molecule | inflammatory bowel disease (IBD) | https://pubmed.ncbi.nlm.nih.gov/34251416/ | |
| RWJ-67657 | No | IL-1b-induced INAVA condensates | INAVA | p38 MAPK | Dissolver | small molecule | inflammatory bowel disease (IBD) | https://pubmed.ncbi.nlm.nih.gov/34251416/ | |
| SB202190 | No | IL-1b-induced INAVA condensates | INAVA | p38 MAPK | Dissolver | small molecule | inflammatory bowel disease (IBD) | https://pubmed.ncbi.nlm.nih.gov/34251416/ | |
| SB203580 | No | IL-1b-induced INAVA condensates | INAVA | p38 MAPK | Dissolver | small molecule | inflammatory bowel disease (IBD) | https://pubmed.ncbi.nlm.nih.gov/34251416/ | |
| SB220025 | No | IL-1b-induced INAVA condensates | INAVA | p38 MAPK | Dissolver | small molecule | inflammatory bowel disease (IBD) | https://pubmed.ncbi.nlm.nih.gov/34251416/ | |
| SB242235 | No | IL-1b-induced INAVA condensates | INAVA | p38 MAPK | Dissolver | small molecule | inflammatory bowel disease (IBD) | https://pubmed.ncbi.nlm.nih.gov/34251416/ | |
| SHP099 | No | mutant SHP2 condensates | mutant SHP2 | SHP2 | Dissolver | small molecule | SHP2‒associated cancers | https://pubmed.ncbi.nlm.nih.gov/38451719/ | |
| Sorafenib | Yes | Stress granules | G3BP1, HuR | Tyrosine kinase | Inducer | small molecule | renal cancer, drug resistance | https://pubmed.ncbi.nlm.nih.gov/37216166/ | |
| Thimesoral | No | INAVA condensates | INAVA | Thiol oxidizer | Inducer | small molecule | inflammatory bowel disease (IBD) | https://pubmed.ncbi.nlm.nih.gov/34251416/ | |
| Torin 1 | No | Paraspeckles | NEAT1_2 | mTOR | Dissolver | small molecule | https://pubmed.ncbi.nlm.nih.gov/36099417/ | ||
| Torin 1 | No | Stress granules | G3BP1 | mTOR | Dissolver | small molecule | https://pubmed.ncbi.nlm.nih.gov/36099417/ | ||
| Vitamin C | Yes | 5hmC-DNA | 5hmC-DNA | unknown | Inducer | small molecule | colorectal cancer | https://pubmed.ncbi.nlm.nih.gov/38583183/ | |
| Vitamin C | Yes | PML body | PML | unknown | Inducer | small molecule | colorectal cancer | https://pubmed.ncbi.nlm.nih.gov/38583183/ | |
| Vitamin C | Yes | Cajal body | Coilin | unknown | Inducer | small molecule | colorectal cancer | https://pubmed.ncbi.nlm.nih.gov/38583183/ | |
| VX702 | No | IL-1b-induced INAVA condensates | INAVA | p38 MAPK | Dissolver | small molecule | inflammatory bowel disease (IBD) | https://pubmed.ncbi.nlm.nih.gov/34251416/ | |
| Z-leu3-VS | No | INAVA condensates | INAVA | Proteasome | Inducer | small molecule | inflammatory bowel disease (IBD) | https://pubmed.ncbi.nlm.nih.gov/34251416/ | |
| Gefitinib | Yes | p62/NBR1 condensates | p62, NBR1 | Epidermal growth factor receptor erbB1 | Inducer | small molecule | https://pubmed.ncbi.nlm.nih.gov/37847732/ | ||
| (R)-lipoic acid | No | Stress granules | G3BP1 | HDAC | Dissolver | small molecule | https://pubmed.ncbi.nlm.nih.gov/37322067/ | ||
| 1,6-hexanediol | No | non-specific | Dissolver | small molecule | https://pubmed.ncbi.nlm.nih.gov/27768897/ | ||||
| 17‐Allylamino‐17‐demethoxygeldanamycin | 17AAG | No | Stress granules | G3BP2 | HSP90 | Inducer | small molecule | https://pubmed.ncbi.nlm.nih.gov/33738926/ | |
| 17‐Allylamino‐17‐demethoxygeldanamycin | 17AAG | No | P bodies | DCP1A | HSP90 | Dissolver | small molecule | https://pubmed.ncbi.nlm.nih.gov/33738926/ | |
| 17‐Allylamino‐17‐demethoxygeldanamycin | 17AAG | No | Nuclear speckles | SC35, DYRK3 | HSP90 | Localizer | small molecule | https://pubmed.ncbi.nlm.nih.gov/33738926/ | |
| 2-[2-(3-chlorophenyl)hydrazinylidene]-propanedinitrile | CCCP | No | Proteasome storage granules | Rpn1 | ATP synthesis | Inducer | small molecule | https://pubmed.ncbi.nlm.nih.gov/35975718/ | |
| 2-aryl-4-aminothiazole | No | Nuclear speckles | SNMDC1, SRRM2 | SMNDC1 | Dissolver | small molecule | https://pubmed.ncbi.nlm.nih.gov/37587144/ | ||
| 3,4,5,4′-tetramethoxystilbene | No | Stress granules | G3BP, PABPC1, TIA1 | Inducer | small molecule | https://pubmed.ncbi.nlm.nih.gov/34432484/ | |||
| 3a | No | SARS-CoV-2 nucleocapsid condensates | SARS-CoV-2 Nucleocapsid | SARS-CoV-2 RNA-dependent RNA polymerase | Dissolver | small molecule | broad range viral infections | https://pubmed.ncbi.nlm.nih.gov/37834006/ | |
| 4-Hydroxynonenal | No | Stress granules | TDP-43 | TDP-43 | Inducer | small molecule | https://pubmed.ncbi.nlm.nih.gov/25998392/ | ||
| 5-diphospho-inositol-1,2,3,4,6-pentakisphosphate | 5-InsP7 | No | Nucleolus | Nucleostemin | Inducer | small molecule | https://pubmed.ncbi.nlm.nih.gov/36671538/ | ||
| 6-thioguanine | Yes | Stress granules | G3BP1, TIAR, eIF3A, PABP | HGPRTase | Inducer | small molecule | influenza A virus (IAV) | https://pubmed.ncbi.nlm.nih.gov/33762409/ | |
| 6-thioguanosine | No | Stress granules | G3BP1, TIAR, eIF3A, PABP | Inducer | small molecule | influenza A virus (IAV) | https://pubmed.ncbi.nlm.nih.gov/33762409/ | ||
| 8-Hydroxyquinoline | No | Stress granules | G3BP1 | unknown | Dissolver | small molecule | amyotrophic lateral sclerosis (ALS) / frontotemporal dementia (FTD) | https://pubmed.ncbi.nlm.nih.gov/31272829/ | |
| A2 | No | TDP-43 anisosomes | TDP43 mutants | unknown | Dissolver | small molecule | neurodegeneration | https://pubmed.ncbi.nlm.nih.gov/37937963/ | |
| A2 | No | NCOR2 anisosomes | NCOR2 | unknown | Inducer | small molecule | neurodegeneration | https://pubmed.ncbi.nlm.nih.gov/37937963/ | |
| A5 | No | TDP-43 anisosomes | TDP43 mutants | unknown | Dissolver | small molecule | neurodegeneration | https://pubmed.ncbi.nlm.nih.gov/37937963/ | |
| A5 | No | NCOR2 anisosomes | NCOR2 | unknown | Dissolver | small molecule | neurodegeneration | https://pubmed.ncbi.nlm.nih.gov/37937963/ | |
| ABT-888 | No | PAR-mediated PARIS aggregation | PARIS | PARP | Inducer | small molecule | Parkinson's disease | https://pubmed.ncbi.nlm.nih.gov/37870275/ | |
| Actinomycin D | Yes | Stress granules | GRP94, B2M RNA | DNA | Dissolver | small molecule | https://pubmed.ncbi.nlm.nih.gov/34244458/ | ||
| Alectinib | Yes | EML4-ALK cytoplasmic foci | EML4-ALK V1 | ALK | Inducer | small molecule | cancer | https://pubmed.ncbi.nlm.nih.gov/34661367/ | |
| ALW-II-41-27 | No | EphA2 membrane condensates | EphA2 | EphA2 | Dissolver | small molecule | colon cancer | https://pubmed.ncbi.nlm.nih.gov/37980165/ | |
| Aminocyclopropenone 1n | No | BRD4 in vitro condensates, trancriptional condensates | BRD4 | BRD4 | Dissolver | small molecule | colorectal cancer | https://pubmed.ncbi.nlm.nih.gov/35159127/ | |
| Anisomycin | No | Stress granules | G3BP1 | unknown | Dissolver | small molecule | amyotrophic lateral sclerosis (ALS) / frontotemporal dementia (FTD) | https://pubmed.ncbi.nlm.nih.gov/31272829/ | |
| Anisomycin | No | Stress granules | G3BP1 | ribosome | Dissolver | small molecule | https://pubmed.ncbi.nlm.nih.gov/38105199/ | ||
| Antimycin A | No | Proteasome storage granules | Rpn1 | Complex III | Inducer | small molecule | https://pubmed.ncbi.nlm.nih.gov/35975718/ | ||
| Apigenin | API | No | Stress granules | HuR, G3BP1 | HuR | Inducer | small molecule | age-related skeletal disorders | https://pubmed.ncbi.nlm.nih.gov/38375951/ |
| Avrainvillamide | No | Nucleolus | mutant NPM1 | NPM1 | Localizer | small molecule | acute myeloid leukemia (AML) | https://pubmed.ncbi.nlm.nih.gov/27906185/ | |
| AZD8055 | No | Stress granules | G3BP1 | mTOR | Dissolver | small molecule | https://pubmed.ncbi.nlm.nih.gov/30923191/ | ||
| b-AP15 | No | Stress granules | G3BP | DUBs | Inducer | small molecule | https://pubmed.ncbi.nlm.nih.gov/33687997/ | ||
| BAY 1892005 | No | p53 mutant condensates | p53 mutant | p53 DNA-binding defective mutant | Inducer | small molecule | https://pubmed.ncbi.nlm.nih.gov/32927263/ | ||
| BAY 1892005 | No | p53 mutant condensates | p53 mutant | p53 structural mutant | Dissolver | small molecule | https://pubmed.ncbi.nlm.nih.gov/32927263/ | ||
| BAY 249716 | No | p53 mutant condensates | p53 mutant | p53 DNA-binding defective mutant | Inducer | small molecule | https://pubmed.ncbi.nlm.nih.gov/32927263/ | ||
| BAY 249716 | No | p53 mutant condensates | p53 mutant | p53 structural mutant | Dissolver | small molecule | https://pubmed.ncbi.nlm.nih.gov/32927263/ | ||
| Benzethonium | No | Stress granules | G3BP1 | unknown | Dissolver | small molecule | amyotrophic lateral sclerosis (ALS) / frontotemporal dementia (FTD) | https://pubmed.ncbi.nlm.nih.gov/31272829/ | |
| BI-3802 | No | BCL6 condensates | BCL6 | BCL6 | Inducer | small molecule | https://pubmed.ncbi.nlm.nih.gov/33208943/ | ||
| BIBW2992 | No | Stress granules | n/a | EGFR signaling | n/a | small molecule | non-small cell lung cancer (NSCLC) | https://pubmed.ncbi.nlm.nih.gov/35433677/ | |
| Bicalutamide | Yes | Androgen receptor foci | Androgen receptor | Androgen receptor | Dissolver | small molecule | castration-resistant prostate cancer | https://pubmed.ncbi.nlm.nih.gov/36535377/ | |
| Bicalutamide | Yes | Androgen receptor foci | Mutant androgen receptor | Androgen receptor | Inducer | small molecule | castration-resistant prostate cancer; drug resistance | https://pubmed.ncbi.nlm.nih.gov/36535377/ | |
| BIX01294 | No | Viral inclusion bodies | SeV | EHMT methyltransferase | Dissolver | small molecule | RNA viruses like Influenza, Sendai and vesicular stomatitis virus (VSV) | https://www.biorxiv.org/content/10.1101/2023.11.01.564969v1 | |
| BMH-21 | No | DNA damage foci | TopBP1, pre-rRNA, gH2AX | RNA polymerase I | Dissolver | small molecule | https://pubmed.ncbi.nlm.nih.gov/37582658/ | ||
| BMH-21 | No | Nucleolus | UBF, NPM1 | RNA Pol I | Morpher | small molecule | https://www.biorxiv.org/content/10.1101/2021.09.09.459702v2 | ||
| BMH21 | No | Nucleolus | Nucleolin, NPM1 | Pol1 | Localizer | small molecule | cancer | https://pubmed.ncbi.nlm.nih.gov/24952786/ | |
| Bortezomib | Yes | Stress granules | G3BP | 26S proteasome | Inducer | small molecule | https://pubmed.ncbi.nlm.nih.gov/33687997/ | ||
| C1 | No | Tau aggregation and in vitro droplets | Tau | Dissolver | small molecule | neurodegeneration | https://pubmed.ncbi.nlm.nih.gov/34008959/ | ||
| C16 | No | Stress granules | G3BP1|PPRV-Nucleocapsid | PKR | Dissolver | small molecule | peste des petits ruminants virus (PPRV) infection | https://pubmed.ncbi.nlm.nih.gov/36651745/ | |
| CAY10626 | No | Paraspeckles | NEAT1_2 | PI3K/mTOR | Dissolver | small molecule | https://pubmed.ncbi.nlm.nih.gov/36099417/ | ||
| CB-5083 | No | Stress granules | G3BP | p97 | Inducer | small molecule | https://pubmed.ncbi.nlm.nih.gov/33687997/ | ||
| Cephaeline | No | Stress granules | G3BP1 | ribosome | Dissolver | small molecule | https://pubmed.ncbi.nlm.nih.gov/38105199/ | ||
| Ceritinib | Yes | EML4-ALK cytoplasmic foci | EML4-ALK V1 | ALK | Dissolver | small molecule | cancer | https://pubmed.ncbi.nlm.nih.gov/34661367/ | |
| Chidamide | No | YY1 transcriptional condensates | YY1, HDAC1/3 | HDAC | Inducer | small molecule | acute myeloid leukemia (AML) | https://pubmed.ncbi.nlm.nih.gov/36424383/ | |
| Colchicine | Yes | STING condensate gel-like transition | STING | Microtubule | Morpher | small molecule | DNA viruses | https://pubmed.ncbi.nlm.nih.gov/33833429/ | |
| Curcumin | No | FUS in vitro condensates, stress granules | FUS | unknown | Dissolver | small molecule | amyotrophic lateral sclerosis (ALS)/frontotemporal dementia (FTD) | https://pubmed.ncbi.nlm.nih.gov/37158592/ | |
| CX-5461 | No | Nucleolus | rRNA, H2B, RNA Pol I, Fibrillarin, gH2AX, topoisomerase I | ribosome synthesis | Morpher | small molecule | https://pubmed.ncbi.nlm.nih.gov/35978024/ | ||
| CX-5461 | No | Nucleolus | UBF, NPM1 | RNA Pol I | Morpher | small molecule | https://www.biorxiv.org/content/10.1101/2021.09.09.459702v2 | ||
| Cycloheximide | No | Stress granules | eIF3η, G3BP1 | Protein synthesis | Dissolver | small molecule | red-spotted grouper nervous necrosis virus (RGNNV) infection | https://pubmed.ncbi.nlm.nih.gov/35935992/ | |
| Cycloheximide | No | Stress granules | G3BP1 | ribosome | Dissolver | small molecule | https://pubmed.ncbi.nlm.nih.gov/38105199/ | ||
| Cytochalasin D | No | Refractile bodies | RB | Actin | Morpher | small molecule | Eimeria tenella infection | https://pubmed.ncbi.nlm.nih.gov/37033474/ | |
| Daunorubicin | Yes | Stress granules | G3BP1 | DNA topoisomerase I/II | Dissolver | small molecule | amyotrophic lateral sclerosis (ALS) / frontotemporal dementia (FTD) | https://pubmed.ncbi.nlm.nih.gov/31272829/ | |
| Digitoxin | Yes | Stress granules | G3BP1 | Na/K transporting ATPase | Dissolver | small molecule | amyotrophic lateral sclerosis (ALS) / frontotemporal dementia (FTD) | https://pubmed.ncbi.nlm.nih.gov/31272829/ | |
| DNL343 | No | Stress granules | truncated TDP-43, G3BP1 | eIF2B | Dissolver | small molecule | ALS | https://pubmed.ncbi.nlm.nih.gov/38511649/ | |
| Doxorubicin | Yes | Stress granules | G3BP1 | DNA topoisomerase II | Dissolver | small molecule | amyotrophic lateral sclerosis (ALS) / frontotemporal dementia (FTD) | https://pubmed.ncbi.nlm.nih.gov/31272829/ | |
| Doxorubicin | Yes | p53 deltaN invitro reconstituted condensates | p53 deltaN | DNA topoisomerase II | Inducer | small molecule | cancer, drug resistance | https://pubmed.ncbi.nlm.nih.gov/38435052/ | |
| Efavirenz | Yes | Stress granules | TIA1 | LINE-1 | Dissolver | small molecule | triple negative breast cancer (TNBC), drug resistance | https://pubmed.ncbi.nlm.nih.gov/34857678/ | |
| Emetine | Yes | Stress granules | G3BP1 | ribosome | Dissolver | small molecule | https://pubmed.ncbi.nlm.nih.gov/38105199/ | ||
| Enzalutamide | Yes | Androgen receptor foci | Androgen receptor | Androgen receptor | Dissolver | small molecule | castration-resistant prostate cancer; drug resistance | https://pubmed.ncbi.nlm.nih.gov/36535377/ | |
| Enzalutamide | Yes | Androgen receptor foci | Mutant androgen receptor | Androgen receptor | Inducer | small molecule | castration-resistant prostate cancer; drug resistance | https://pubmed.ncbi.nlm.nih.gov/36535377/ | |
| EPI-001 | No | Androgen receptor foci | Androgen receptor | Androgen receptor | Dissolver | small molecule | castration-resistant prostate cancer; drug resistance | https://pubmed.ncbi.nlm.nih.gov/36535377/ | |
| Erlotinib | Yes | Stress granules | n/a | EGFR signaling | n/a | small molecule | non-small cell lung cancer (NSCLC) | https://pubmed.ncbi.nlm.nih.gov/35433677/ | |
| ET516 | No | Androgen receptor condensates | Androgen receptor | Androgen receptor | Dissolver | small molecule | castration-resistant prostate cancer | https://pubmed.ncbi.nlm.nih.gov/36229685/ | |
| Etoposide | Yes | Nucleolus | NONO, Fibrillarin | topoisomerase II | Localizer | small molecule | cancer | https://pubmed.ncbi.nlm.nih.gov/38224452/ | |
| Everolimus | Yes | Stress granules | G3BP1 | mTORC1 | Dissolver | small molecule | https://pubmed.ncbi.nlm.nih.gov/30923191/ | ||
| G007-LK | No | Degradation-competent Axin puncta | Axin, b-catenin | Tankyrase | Inducer | small molecule | cancer | https://pubmed.ncbi.nlm.nih.gov/26930278/ | |
| G3Ia | No | G3BP1/RNA/Caprin1 in vitro reconstituted condensates, Stress granules | G3BP1, eIF3h, PABPC1 | G3BP1 | Dissolver | small molecule | neurodegeneration, cancer | https://pubmed.ncbi.nlm.nih.gov/38284934/ | |
| G3Ib | No | G3BP1/RNA/Caprin1 in vitro reconstituted condensates, Stress granules | G3BP1, eIF3h, PABPC1 | G3BP1 | Dissolver | small molecule | neurodegeneration, cancer | https://pubmed.ncbi.nlm.nih.gov/38284934/ | |
| Gallic acid | GA | No | Tau condensates | Tau | Tau | Inducer, Morpher | small molecule | tauopathies | https://pubmed.ncbi.nlm.nih.gov/38545836/ |
| Gefitinib | Yes | Stress granules | n/a | EGFR signaling | n/a | small molecule | non-small cell lung cancer (NSCLC) | https://pubmed.ncbi.nlm.nih.gov/35433677/ | |
| Geldanamycin | GA | No | Nuclear speckles | SC35, DYRK3 | HSP90 | Localizer | small molecule | https://pubmed.ncbi.nlm.nih.gov/33738926/ | |
| Geldanamycin | GA | No | Stress granules | G3BP2 | HSP90 | Inducer | small molecule | https://pubmed.ncbi.nlm.nih.gov/33738926/ | |
| Geldanamycin | GA | No | P bodies | DCP1A | HSP90 | Dissolver | small molecule | https://pubmed.ncbi.nlm.nih.gov/33738926/ | |
| Glyceollin I | No | Eleanor RNA cloud | Eleanor ncRNA | unknown | Dissolver | small molecule | breast cancer, drug resistance | https://pubmed.ncbi.nlm.nih.gov/30315184/ | |
| Daporinad | No | DNA damage foci | γH2AX | NAMPT | Inducer | small molecule | Drug resistance | https://pubmed.ncbi.nlm.nih.gov/36849518/ | |
| GSK1059615 | No | Paraspeckles | NEAT1_2 | PI3K/mTOR | Dissolver | small molecule | https://pubmed.ncbi.nlm.nih.gov/36099417/ | ||
| GSK2606414 | No | Stress granules | G3BP1, RGNNV coat protein (CP) | PERK | Dissolver | small molecule | red-spotted grouper nervous necrosis virus (RGNNV) infection | https://pubmed.ncbi.nlm.nih.gov/35935992/ | |
| GSK-626616 | No | CAMKV condensates | CAMKV | DYRK3 | Inducer | small molecule | neuroblastoma | https://pubmed.ncbi.nlm.nih.gov/38255303/ | |
| GSK-626616 | No | Stress granules | SC35, DYRK3, Pericentrin, PABP, PCM1 | DYRK3 | Inducer | small molecule | https://pubmed.ncbi.nlm.nih.gov/29973724/ | ||
| GSK-J4 | No | Core regulatory circuitry condensates | HOXB8, FOSL1 | H3K27 demethylase | Dissolver | small molecule | osteosarcoma, drug resistance | https://pubmed.ncbi.nlm.nih.gov/34432948/ | |
| Guanabenz | Yes | Conductin condensates | Conductin | Gαi2 | Inducer | small molecule | colorectal cancer | https://pubmed.ncbi.nlm.nih.gov/35115535/ | |
| Harmine | No | CAMKV condensates | CAMKV | DYRK3 | Inducer | small molecule | neuroblastoma | https://pubmed.ncbi.nlm.nih.gov/38255303/ | |
| Harringtonine | No | Stress granules | G3BP1 | ribosome | Dissolver | small molecule | https://pubmed.ncbi.nlm.nih.gov/38105199/ | ||
| icFSP1 | No | FSP1 condensates | FSP1 | FSP1 | Inducer | small molecule | cancer | https://pubmed.ncbi.nlm.nih.gov/37380771/ | |
| IGS2.7 | No | Stress granules | TDP-43|F actin | CK-1 | Dissolver | small molecule | amyotrophic lateral sclerosis (ALS) | https://pubmed.ncbi.nlm.nih.gov/38325718/ | |
| INK128 | No | Paraspeckles | NEAT1_2 | mTOR | Dissolver | small molecule | https://pubmed.ncbi.nlm.nih.gov/36099417/ | ||
| ISRIB | No | Stress granules | eIF3a, G3BP1 | eIF2b | Dissolver | small molecule | https://pubmed.ncbi.nlm.nih.gov/25719440/ | ||
| Kanamycin A | Yes | SARS-CoV-2 Nucleocapsid condensates|SARS-CoV-2 Nucleocapsid and RNA in vitro condensates | SARS-CoV-2 N-protein | RNA | Dissolver | small molecule | COVID | https://pubmed.ncbi.nlm.nih.gov/33290746/ | |
| Lactimidomycin | No | Stress granules | G3BP1 | ribosome | Dissolver | small molecule | https://pubmed.ncbi.nlm.nih.gov/38105199/ | ||
| Leptomycin B | No | Nup98-HoxA9 aberrant Transcriptional condensates | Nup98-HoxA9 | CRM1 | Dissolver | small molecule | https://pubmed.ncbi.nlm.nih.gov/26740045/ | ||
| LFM-A13 | No | Stress granules | G3BP1|BTK | BTK | Dissolver | small molecule | viral infection | https://pubmed.ncbi.nlm.nih.gov/35798143/ | |
| Lipoamide | No | Stress granules | G3BP1 | HDAC | Dissolver | small molecule | https://pubmed.ncbi.nlm.nih.gov/37322067/ | ||
| Lipoamide | No | Stress granules | FUS, G3BP1, PABPC1, TIAL1, EWSR1 | disordered proteins | Dissolver | small molecule | Neurodegenerative disease | https://www.biorxiv.org/content/10.1101/721001v3 | |
| Lipoic acid | No | Stress granules | FUS, G3BP1, PABPC1, TIAL1, EWSR1 | unknown | Dissolver | small molecule | Neurodegenerative disease | https://www.biorxiv.org/content/10.1101/721001v3 | |
| Lopinavir | Yes | ATG4B condensates | ATG4B | HIV protease inhibitor | Inducer | small molecule | gastric cancer metastasis | https://pubmed.ncbi.nlm.nih.gov/38433354/ | |
| Lorecivivint | No | Nuclear speckles, FOXO1 nuclear foci | phospho-SC35, FOXO1 | CLK2, DYRK1A | Inducer | small molecule | knee osteoarthritis | https://pubmed.ncbi.nlm.nih.gov/31132406/ | |
| Lorlatinib | Yes | EML4-ALK cytoplasmic foci | EML4-ALK V1 | ALK | Dissolver | small molecule | cancer | https://pubmed.ncbi.nlm.nih.gov/34661367/ | |
| Lurbinectedin | Yes | Aberrant EWS-WT1 transcriptional condensate & nucleolus | EWS1-WT1, nucleolin | EWSR1 fusions | Localizer | small molecule | Desmoplastic small round cell tumor (DSRCT) | https://pubmed.ncbi.nlm.nih.gov/35657345/ | |
| Lurbinectedin | Yes | Aberrant EWS-FLI1 transcriptional condensate & nucleolus | EWS1-FLI, nucleolin | EWSR1 fusions | Localizer | small molecule | Ewing sarcoma | https://pubmed.ncbi.nlm.nih.gov/27697767 | |
| Madrasin | No | Stress-like granules | G3BP1 | Spliceosome | Inducer | small molecule | https://pubmed.ncbi.nlm.nih.gov/38366783/ | ||
| MI-2 | No | Stress granules | FUS, G3BP1, Fibrillarin | Menin-MLL | Localizer | small molecule | https://pubmed.ncbi.nlm.nih.gov/36606141/ | ||
| MI-3 | No | Stress granules | FUS, G3BP1, Fibrillarin | Menin-MLL | Localizer | small molecule | https://pubmed.ncbi.nlm.nih.gov/36606141/ | ||
| Mitoxantrone | Yes | Stress granules | G3BP1 | DNA | Dissolver | small molecule | amyotrophic lateral sclerosis (ALS) / frontotemporal dementia (FTD) | https://pubmed.ncbi.nlm.nih.gov/31272829/ | |
| MK.2206 | No | Stress granules | n/a | AKT | n/a | small molecule | non-small cell lung cancer (NSCLC) | https://pubmed.ncbi.nlm.nih.gov/35433677/ | |
| ML-792 | No | ALT telomere clusters | TRF1-Fok1, PML | SUMO-activating enzyme | Dissolver | small molecule | ALT cancer | https://www.biorxiv.org/content/10.1101/2024.02.29.582813v1 | |
| MS023 | No | Stress granules | G3BP1, Nucleocapsid | PRMT | Inducer | small molecule | COVID | https://pubmed.ncbi.nlm.nih.gov/34029587/ | |
| MS37452 | No | H3K27me3/PRC in vitro reconstituted condensates, facultative heterochromatin | PRC1, H3K27me3 | CBX7 | Morpher | small molecule | cancer, acute myeoloid leukemia (AML) | https://www.biorxiv.org/content/10.1101/2023.12.02.569699v1 | |
| NMS-873 | No | Stress granules | G3BP | p97 | Inducer | small molecule | https://pubmed.ncbi.nlm.nih.gov/33687997/ | ||
| Nucleozin | No | Viral factories | Nucleoprotein, Rab11 | Influenza nucleoprotein | Morpher | small molecule | influenza A virus (IAV) | https://pubmed.ncbi.nlm.nih.gov/37013374/ | |
| Olaparib | Yes | DNA damage foci | γH2AX | PARP | Inducer | small molecule | drug resistance | https://www.biorxiv.org/content/10.1101/2022.04.27.489674v2 | |
| Olaparib | Yes | DNA damage foci | γH2AX | PARP | Inducer | small molecule | https://pubmed.ncbi.nlm.nih.gov/29992957/ | ||
| Oligomycin A | No | Proteasome storage granules | Rpn1 | ATP synthase | Inducer | small molecule | https://pubmed.ncbi.nlm.nih.gov/35975718/ | ||
| Oxaliplatin | Yes | Nucleolus | NPM1 | DNA | Localizer | small molecule | cancer | https://pubmed.ncbi.nlm.nih.gov/31670961/ | |
| Oxaliplatin | Yes | Nucleolus | NPM1, Fibrillarin | DNA | Localizer | small molecule | cancer | https://pubmed.ncbi.nlm.nih.gov/36351392/ | |
| Pactamycin | No | Stress granules | G3BP1 | ribosome | Dissolver | small molecule | https://pubmed.ncbi.nlm.nih.gov/38105199/ | ||
| Palbociclib | PD.0332991 | Yes | Stress granules | n/a | CDK4/6 | n/a | small molecule | non-small cell lung cancer (NSCLC) | https://pubmed.ncbi.nlm.nih.gov/35433677/ |
| PD16685 | No | Pronucleus | Chromatin | WEE1/2 kinase | Dissolver | small molecule | https://pubmed.ncbi.nlm.nih.gov/37578641/ | ||
| PD184352 | No | P bodies | DDX6 | KRAS, NRAS | Dissolver | small molecule | cancer, drug resistance | https://pubmed.ncbi.nlm.nih.gov/37370689/ | |
| Penfluridol | Yes | Stress granules | G3BP1 | Dopamine receptor | Dissolver | small molecule | amyotrophic lateral sclerosis (ALS) / frontotemporal dementia (FTD) | https://pubmed.ncbi.nlm.nih.gov/31272829/ | |
| PI-103 | No | Paraspeckles | NEAT1/2 | PI3K/mTOR/DNA-PK | Dissolver | small molecule | https://pubmed.ncbi.nlm.nih.gov/36099417/ | ||
| Piceatannol | No | Stress granules | G3BP, PABPC1, TIA1 | Inducer | small molecule | https://pubmed.ncbi.nlm.nih.gov/34432484/ | |||
| PJ34 | No | Stress granules | mutant PARP12 | PARP | Localizer | small molecule | https://pubmed.ncbi.nlm.nih.gov/29070863/ | ||
| PKI-402 | No | Stress granules | G3BP1, YB-1 | PI3K/mTOR | Inducer | small molecule | drug resistance | https://pubmed.ncbi.nlm.nih.gov/38238825/ | |
| PR-619 | No | Stress granules | G3BP | DUBs | Inducer | small molecule | https://pubmed.ncbi.nlm.nih.gov/33687997/ | ||
| Pterostilbene | No | Stress granule | G3BP, PABPC1, TIA1 | Inducer | small molecule | https://pubmed.ncbi.nlm.nih.gov/34432484/ | |||
| Pyrvinium | Yes | Stress granules | G3BP1 | Androgen receptor | Dissolver | small molecule | amyotrophic lateral sclerosis (ALS) / frontotemporal dementia (FTD) | https://pubmed.ncbi.nlm.nih.gov/31272829/ | |
| Quinacrine | No | Stress granules | G3BP1 | unknown | Dissolver | small molecule | amyotrophic lateral sclerosis (ALS) / frontotemporal dementia (FTD) | https://pubmed.ncbi.nlm.nih.gov/31272829/ | |
| Rapamycin | Yes | Stress granules | n/a | FK506-binding protein 1A | n/a | natural product | non-small cell lung cancer (NSCLC) | https://pubmed.ncbi.nlm.nih.gov/35433677/ | |
| RBN012579 | No | Stress granules | G3BP1, RACK1, RPS6, eIF3h | PARP14 | Dissolver | small molecule | ovarian cancer | https://pubmed.ncbi.nlm.nih.gov/37873085/ | |
| Resveratrol | No | Eleanor RNA cloud | Eleanor ncRNA | Estrogen receptor | Dissolver | small molecule | breast cancer, drug resistance | https://pubmed.ncbi.nlm.nih.gov/30315184/ | |
| Resveratrol | No | Stress granules | G3BP, PABPC1, TIA1 | G3BP | Inducer | small molecule | https://pubmed.ncbi.nlm.nih.gov/34432484/ | ||
| RK33 | No | Stress granules | DDX3, G3BP1 | DDX3 | Dissolver | small molecule | https://pubmed.ncbi.nlm.nih.gov/33049245/ | ||
| SCH772984 | No | glucosome assemblies | PFKL | ERK1/2 | Dissolver | small molecule | cancer | https://pubmed.ncbi.nlm.nih.gov/35122791/ | |
| Selinexor | KPT-330 | Yes | Nucleolus | mutant NPM1 | XPO1/ CRM1 | Localizer | small molecule | AML | https://pubmed.ncbi.nlm.nih.gov/30205049/ |
| SI-2 | No | SRC-2/NSD2 condensates | SRC-3 | SRC-3 | Dissolver | small molecule | drug resistance, multiple myeloma | https://pubmed.ncbi.nlm.nih.gov/33589584/ | |
| Sodium azide | No | Proteasome storage granules | Rpn1 | cytochrome C oxidase | Inducer | small molecule | https://pubmed.ncbi.nlm.nih.gov/35975718/ | ||
| Spautin-1 | No | Stress granules | FUS, G3BP1, Fibrillarin | USP-10 and USP-13 | Localizer | small molecule | https://pubmed.ncbi.nlm.nih.gov/36606141/ | ||
| T-2 toxin | No | Stress granules | G3BP1 | ribosome | Dissolver | small molecule | https://pubmed.ncbi.nlm.nih.gov/38105199/ | ||
| TAK-243 | MLN7243 | No | Stress granules | G3BP1, Ubiquitin | E1 | Inducer | small molecule | https://pubmed.ncbi.nlm.nih.gov/33687997/ | |
| Talazoparib | Yes | Talazoparib | γH2AX | PARP | Inducer | small molecule | drug resistance | https://www.biorxiv.org/content/10.1101/2022.04.27.489674v2 | |
| Tamoxifen | Yes | Transcriptional condensates | MED1 | MED1 | Dissolver | small molecule | cancer | https://pubmed.ncbi.nlm.nih.gov/32554597/ | |
| TC12 | No | Stress granules | G3BP1 | G3BP1 | Inducer | small molecule | https://pubmed.ncbi.nlm.nih.gov/38262290/ | ||
| TC39 | No | Stress granules | G3BP1 | G3BP1 | Inducer | small molecule | https://pubmed.ncbi.nlm.nih.gov/38262290/ | ||
| TC6 | No | Stress granules | G3BP1 | G3BP1 | Inducer | small molecule | https://pubmed.ncbi.nlm.nih.gov/38262290/ | ||
| Temsirolimus | Yes | Stress granules | n/a | PI3K/mTOR signaling | n/a | small molecule | non-small cell lung cancer (NSCLC) | https://pubmed.ncbi.nlm.nih.gov/35433677/ | |
| Torin-1 | No | P bodies | Hedls | mTORC1/2 | Dissolver | small molecule | Karposi's sarcoma-associated herpesvirus (KSHV) infection | https://pubmed.ncbi.nlm.nih.gov/36634147/ | |
| Trabectedin | Yes | Aberrant EWS-FLI1 transcriptional condensate & nucleolus | EWS1-FLI, nucleolin | EWSR1 fusions | Localizer | small molecule | Ewing sarcoma | https://pubmed.ncbi.nlm.nih.gov/27697767 | |
| Trametinib | Yes | P bodies | DDX6 | KRAS, NRAS | Dissolver | small molecule | cancer, drug resistance | https://pubmed.ncbi.nlm.nih.gov/37370689/ | |
| Trichostatin A | No | Stress granules | TIA1 | general HDAC | Dissolver | small molecule | https://pubmed.ncbi.nlm.nih.gov/34345843/ | ||
| Triptolide | No | Stress granules | GRP94, B2M RNA | RNA Pol II | Dissolver | small molecule | https://pubmed.ncbi.nlm.nih.gov/34244458/ | ||
| Topotecan | Yes | Nucleolus | DNA topoisomerase I | DNA topoisomerase | Localizer | small molecule | https://pubmed.ncbi.nlm.nih.gov/11709553/ | ||
| Tryptanthrin | No | in vitro Tau aggregates | Tau | Tau | Dissolver | small molecule | Alzheimer's disease | https://pubmed.ncbi.nlm.nih.gov/38352474/ | |
| Tubastatin | No | Stress granules | TIA1 | HDAC6 | Dissolver | small molecule | https://pubmed.ncbi.nlm.nih.gov/34345843/ | ||
| UNC0642 | No | Viral inclusion bodies | SeV | EHMT methyltransferase | Dissolver | small molecule | RNA viruses like Influenza, Sendai and vesicular stomatitis virus (VSV) | https://www.biorxiv.org/content/10.1101/2023.11.01.564969v1 | |
| UNC6934 | No | Nucleolus | NSD2, Fibrillarin | NSD2 | Localizer | small molecule | https://pubmed.ncbi.nlm.nih.gov/34782742/ | ||
| VER‐155008 | No | Stress granules | G3BP2, PABPC1 | HSP70 | Inducer | small molecule | https://pubmed.ncbi.nlm.nih.gov/33738926/ | ||
| Verdinexor | Yes | TDP-43 anisosomes | TDP43 | XPO1/ CRM1 | Dissolver | small molecule | neurodegeneration | https://pubmed.ncbi.nlm.nih.gov/37937963/ | |
| Vinblastine | Yes | Stress granules | G3BP1 | Tubulin | Dissolver | small molecule | amyotrophic lateral sclerosis (ALS) / frontotemporal dementia (FTD) | https://pubmed.ncbi.nlm.nih.gov/31272829/ | |
| Withaferin A | No | TDP-43 anisosomes | TDP43 | NF-κB | Dissolver | small molecule | neurodegeneration | https://pubmed.ncbi.nlm.nih.gov/37937963/ | |
| WNK-643 | No | TDP-43 anisosomes | TDP43 | WNK kinase | Inducer | small molecule | neurodegeneration | https://pubmed.ncbi.nlm.nih.gov/37937963/ | |
| Wortmannin | No | Stress granules | G3BP1 | PI3K | Dissolver | small molecule | https://pubmed.ncbi.nlm.nih.gov/30923191/ | ||
| XAV939 | No | Degradation-competent Axin puncta | Axin, b-catenin | Tankyrase | Inducer | small molecule | cancer | https://pubmed.ncbi.nlm.nih.gov/26930278/ | |
| ZZW-115 | No | NUPR1 in vitro reconstituted condensates, Stress granules | G3BP1, NUPR1 | NUPR1 | Dissolver | small molecule | KrasG12D-dependent tumors | https://pubmed.ncbi.nlm.nih.gov/38360999/ | |
| Vitamin K3 | Yes | Stress-induced A-bodies | β-amyloid, immunoglobulin light chain, Congo red | unknown | Localizer | small molecule | Alzheimer's disease, AL amyloidosis | https://pubmed.ncbi.nlm.nih.gov/37660155/ | |
| Diclofenac | Yes | Stress-induced A-bodies | β-amyloid, immunoglobulin light chain, Congo red | Cyclooxygenase 1/2 | Localizer | small molecule | Alzheimer's disease, AL amyloidosis | https://pubmed.ncbi.nlm.nih.gov/37660155/ | |
| Doxorubicin | Yes | QKI7-positive stress granules | DNA topoisomerase II | DNA topoisomerase II | Inducer | small molecule | drug resistance | https://pubmed.ncbi.nlm.nih.gov/37379838/ | |
| Cisplatin | Yes | Transcriptional condensate | Med1 | DNA | Dissolver | small molecule | cancer | https://pubmed.ncbi.nlm.nih.gov/32554597/ | |
| Cisplatin | Yes | Nucleolus | Fibrillarin | DNA | Inducer | small molecule | cancer | https://pubmed.ncbi.nlm.nih.gov/32554597/ | |
| Sulforaphane | No | Transcriptional condensates | β-catenin, LEF1, PRMT5 | unknown | Inducer | natural product | colorectal cancer | https://pubmed.ncbi.nlm.nih.gov/30338040/ | |
| Pyrvinium pamoate | PP | Yes | Nuclear speckle | SON | Androgen receptor | Morpher | small molecule | tauopathies; retinopathies | https://pubmed.ncbi.nlm.nih.gov/38659924/ |
| Claramine | No | α-synuclein in vitro reconstituted condensates | α-synuclein | PTP1B | Inducer | small molecule | Parkinson's disease | https://pubmed.ncbi.nlm.nih.gov/38714700/ | |
| Veliparib | No | DNA damage foci | γH2AX | PARP | Inducer | small molecule | https://pubmed.ncbi.nlm.nih.gov/29992957/ | ||
| Talazoparib | Yes | Talazoparib | γH2AX | PARP | Inducer | small molecule | https://pubmed.ncbi.nlm.nih.gov/29992957/ | ||
| JQ1 | No | Transcriptional condensate | Med1 | BRD4 | Dissolver | small molecule | Cancer | https://pubmed.ncbi.nlm.nih.gov/32554597/ | |
| F10 DARPin | No | Aggresome | HDAC6 | HDAC6 | Dissolver | protein | influenza A virus (IAV); Zika virus (ZIKV) | https://pubmed.ncbi.nlm.nih.gov/35476995/ | |
| F10 DARPin | No | Stress granules | G3BP1 | HDAC6 | Dissolver | protein | influenza A virus (IAV); Zika virus (ZIKV) | https://pubmed.ncbi.nlm.nih.gov/35476995/ | |
| Phillygenin | No | Stress granules | G3BP1 | unknown | Inducer | natural product | Avian infectious bronchitis virus (IBV) | https://pubmed.ncbi.nlm.nih.gov/35421804/ | |
| Metformin | Yes | Insulin receptor clusters | Insulin receptor (IR) | AMPK; Mitochondrial complex I | Dissolver | small molecule | Type 2 diabetes | https://pubmed.ncbi.nlm.nih.gov/36473871/ | |
| CP21R7 | No | Viral condensates | SARS-CoV2 N-protein | GSK3 | Inducer | small molecule | COVID | https://pubmed.ncbi.nlm.nih.gov/36795767/ | |
| Autophinib | No | Viral condensates | SARS-CoV2 N-protein | GSK3 | Inducer | small molecule | COVID | https://pubmed.ncbi.nlm.nih.gov/36795767/ | |
| Bortezomib | Yes | Viral condensates | SARS-CoV2 N-protein | Proteasome | Inducer | small molecule | COVID | https://pubmed.ncbi.nlm.nih.gov/36795767/ | |
| Carfilzomib | Yes | Viral condensates | SARS-CoV2 N-protein | Proteasome | Inducer | small molecule | COVID | https://pubmed.ncbi.nlm.nih.gov/36795767/ | |
| Ixazomib | Yes | Viral condensates | SARS-CoV2 N-protein | Proteasome | Inducer | small molecule | COVID | https://pubmed.ncbi.nlm.nih.gov/36795767/ | |
| Oprozomib | No | Viral condensates | SARS-CoV2 N-protein | Proteasome | Inducer | small molecule | COVID | https://pubmed.ncbi.nlm.nih.gov/36795767/ | |
| LY2090314 | No | Viral condensates | SARS-CoV2 N-protein | GSK3 | Inducer | small molecule | COVID | https://pubmed.ncbi.nlm.nih.gov/36795767/ | |
| CHIR-98014 | No | Viral condensates | SARS-CoV2 N-protein | GSK3 | Inducer | small molecule | COVID | https://pubmed.ncbi.nlm.nih.gov/36795767/ | |
| 6-BIO | No | Viral condensates | SARS-CoV2 N-protein | GSK3 | Inducer | small molecule | COVID | https://pubmed.ncbi.nlm.nih.gov/36795767/ | |
| A1070722 | No | Viral condensates | SARS-CoV2 N-protein | GSK3 | Inducer | small molecule | COVID | https://pubmed.ncbi.nlm.nih.gov/36795767/ | |
| Autophinib | No | Viral condensates | SARS-CoV2 N-protein | GSK3 | Inducer | small molecule | COVID | https://pubmed.ncbi.nlm.nih.gov/36795767/ | |
| Laduviglusib | No | Viral condensates | SARS-CoV2 N-protein | GSK3 | Inducer | small molecule | COVID | https://pubmed.ncbi.nlm.nih.gov/36795767/ | |
| Bosutinib | Yes | Viral condensates | SARS-CoV2 N-protein | Src/ABL | Dissolver | small molecule | COVID | https://pubmed.ncbi.nlm.nih.gov/36795767/ | |
| Ponatinib | Yes | Viral condensates | SARS-CoV2 N-protein | Phospholipase A2 | Dissolver | small molecule | COVID | https://pubmed.ncbi.nlm.nih.gov/36795767/ | |
| Olverembatinib | No | Viral condensates | SARS-CoV2 N-protein | ABL | Dissolver | small molecule | COVID | https://pubmed.ncbi.nlm.nih.gov/36795767/ | |
| Salvianolic acid B | SalB | No | Viral condensates | SARS-CoV2 N-protein | unknown | Dissolver | natural product | COVID | https://pubmed.ncbi.nlm.nih.gov/36795767/ |
| Geldanamycin | No | Stress granules | G3BP1/2 | Hsp90 | Inducer | small molecule | Drug resistance; cancer | https://pubmed.ncbi.nlm.nih.gov/38731625/ | |
| Ceritinib | Yes | Stress granules | G3BP1/2 | ALK | Inducer | small molecule | Drug resistance; cancer | https://pubmed.ncbi.nlm.nih.gov/38731625/ | |
| TAT-SIP-C1 | No | Stress granules | G3BP1/2 | Caprin1/G3BP1 | Dissolver | peptide | Drug resistance; cancer | https://pubmed.ncbi.nlm.nih.gov/38731625/ | |
| TAT-SIP-C2 | No | Stress granules | G3BP1/2 | Caprin1/G3BP1 | Dissolver | peptide | Drug resistance; cancer | https://pubmed.ncbi.nlm.nih.gov/38731625/ | |
| SIP-U1-Antp | No | Stress granules | G3BP1/2 | USP10/G3BP1 | Dissolver | peptide | Drug resistance; cancer | https://pubmed.ncbi.nlm.nih.gov/38731625/ | |
| EX527 | No | Virus-induced IRF3 condensates | IRF3, MED1 | SIRT1 | Dissolver | small molecule | Virus infection; age-related immuno-senescence | https://pubmed.ncbi.nlm.nih.gov/35879450/ | |
| Doxorubicin | Adriamycin | Yes | Heterochromatin | H3K9me3, HP1α, DNA | DNA topoisomerase | Inducer | small molecule | Cancer | https://pubmed.ncbi.nlm.nih.gov/37689690/ |
| 5-ALA | 5-aminolevulinic acid | Yes | FMRpolyG / CGG repeat foci | FMRpolyG, CGG repeat | G-quadruplex RNA | Dissolver | metabolite | Fragile X-related tremor/ataxia syndrome (FXTAS) | https://pubmed.ncbi.nlm.nih.gov/33523882/ |
| Tautomycin | No | CGG repeat foci | CGG repeat, Sam68 | Phosphatase 1, 2A, smooth muscle endogenous phosphatase | Dissolver | natural product | Fragile X-related tremor/ataxia syndrome (FXTAS) | https://pubmed.ncbi.nlm.nih.gov/20186122/ | |
| Dihydrocapsaicin | DHC | No | Stress granules | TIA-1, G3BP1, eIF3b, EIF4G | Transient receptor potential cation channel subfamily V member 1 | Inducer | natural product | https://pubmed.ncbi.nlm.nih.gov/34953209/ | |
| 5-fluorouracil | 5-FU | Yes | Cajal bodies | Coilin | Thymidylate synthase | Dissolver; Morpher | small molecule | Colorectal cancer (CRC); drug resistance | https://pubmed.ncbi.nlm.nih.gov/35151311/ |
| Cisplatin | Yes | Cajal bodies | Coilin | DNA | Dissolver; Morpher | small molecule | Colorectal cancer (CRC); drug resistance | https://pubmed.ncbi.nlm.nih.gov/35151311/ | |
| Raltitrexed | No | Cajal bodies | Coilin | Thymidylate synthase | Dissolver; Morpher | small molecule | Colorectal cancer (CRC); drug resistance | https://pubmed.ncbi.nlm.nih.gov/35151311/ | |
| Apatinib | No | Cajal bodies | Coilin | Vascular endothelial growth factor receptor 2 | Dissolver; Morpher | small molecule | Colorectal cancer (CRC); drug resistance | https://pubmed.ncbi.nlm.nih.gov/35151311/ | |
| Artemisinin | Yes | Cajal bodies | Coilin | Ferriprotoporphyrin IX | Dissolver | small molecule | Colorectal cancer (CRC); drug resistance | https://pubmed.ncbi.nlm.nih.gov/35151311/ | |
| Doxorubicin | Yes | DNA damage foci | 53BP1 | DNA topoisomerase II | Inducer | small molecule | https://pubmed.ncbi.nlm.nih.gov/34504951/ | ||
| Raloxifene | Yes | Hypoxia-induced stress granules | TIAR, G3BP2 | Estrogen receptor | Inducer | small molecule | Glioblastoma (GBM) | https://pubmed.ncbi.nlm.nih.gov/33203845/ | |
| Morusin | No | Stress granules | G3BP1 | unknown | Inducer | natural product | Cancer; drug resistance | https://pubmed.ncbi.nlm.nih.gov/32731602/ | |
| Lapatinib | Yes | Stress granules | FMRP, G3BP, DDX3, eIF4GI | erbB-2 | Inducer | small molecule | Breast cancer; drug resistance | https://pubmed.ncbi.nlm.nih.gov/32365111/ | |
| Imatinib | Yes | BCR-ABL positive stress granules | BCR-ABL | BCR-ABL | Dissolver | small molecule | Chronic myelogenous leukemia (CML) | https://pubmed.ncbi.nlm.nih.gov/31735741/ | |
| PIM447 | No | P-bodies | EDC3, DCP1a | PIM | Inducer | small molecule | Cancer | https://pubmed.ncbi.nlm.nih.gov/33586867/ | |
| GSK690693 | No | P-bodies | EDC3, DCP1a | AKT | Inducer | small molecule | Cancer | https://pubmed.ncbi.nlm.nih.gov/33586867/ | |
| GSK626616 | No | Stress granules | PABP1, G3BP1 | DYRK3 | Morpher | small molecule | https://pubmed.ncbi.nlm.nih.gov/23415227/ | ||
| JAK3 inhibitor IV | No | Stress granules | PABP1, G3BP1 | JAK1/3 | Morpher | small molecule | https://pubmed.ncbi.nlm.nih.gov/23415227/ | ||
| Harmine | No | Stress granules | PABP1, G3BP1 | Amine oxidase A | Morpher | small molecule | https://pubmed.ncbi.nlm.nih.gov/23415227/ | ||
| CDK2 inhibitor IV | No | Stress granules | PABP1, G3BP1 | CDK2 | Morpher | small molecule | https://pubmed.ncbi.nlm.nih.gov/23415227/ | ||
| CDK4 inhibitor III | No | Stress granules | PABP1, G3BP1 | CDK4 | Morpher | small molecule | https://pubmed.ncbi.nlm.nih.gov/23415227/ | ||
| Wee1/Chk1 inhibitor | No | Stress granules | PABP1, G3BP1 | Wee1/Chk1 | Morpher | small molecule | https://pubmed.ncbi.nlm.nih.gov/23415227/ | ||
| HMS3229I17 | No | Stress granules | PABP1, G3BP1 | PKR | Morpher | small molecule | https://pubmed.ncbi.nlm.nih.gov/23415227/ | ||
| Geldanamycin | No | Stress granules | Hsp90, Nrd1 | Hsp90 | Dissolver | small molecule | https://pubmed.ncbi.nlm.nih.gov/39040524/ | ||
| Myricetin | No | α-Synuclein in vitro condensates | α-Synuclein | unknown | Morpher | natural product | Parkinson's disease | https://pubmed.ncbi.nlm.nih.gov/35657723/ | |
| Curcumin | No | α-Synuclein in vitro condensates | α-Synuclein | unknown | Dissolver | natural product | Parkinson's disease | https://pubmed.ncbi.nlm.nih.gov/38731658/ | |
| AMI-1 | No | Axonal FUS granules | FUS-P525L, FUS, SMN | Histone methyltrasferase | Dissolver | small molecule | Spinal muscular atrophy (SMA) | https://pubmed.ncbi.nlm.nih.gov/39052476/ | |
| ADOX | No | Nuclear stress granules | FUS | S-adenosinemethionine-dependent methytransferase | Inducer | small molecule | Spinal muscular atrophy (SMA) | https://pubmed.ncbi.nlm.nih.gov/39052476/ | |
| MS023 | No | Nuclear stress granules | FUS | PRMT | Inducer | small molecule | Spinal muscular atrophy (SMA) | https://pubmed.ncbi.nlm.nih.gov/39052476/ | |
| Olaparib + Cisplatin | Yes | KAT6A condensates | KAT6A|PARP1 | PARP + DNA | Inducer | combination | Ovarian cancer; drug resistance | https://pubmed.ncbi.nlm.nih.gov/38973255/ | |
| GSK-J4 | No | Transcriptional condensate | SP1 | H3K27me3 demethylase | Dissolver | small molecule | Lung adenocarcinoma (LUAD) | https://pubmed.ncbi.nlm.nih.gov/38976739/ | |
| Shikonin | No | Tau in vitro condensates; Tau fibrils | Tau | unknown | Dissolver | natural product | Alzheimer's disease; Parkinson's disease | https://pubmed.ncbi.nlm.nih.gov/35120943/ | |
| Suramin | Yes | Tau in vitro condensates | Tau | TNFα | Inducer | small molecule | Alzheimer's disease | https://pubmed.ncbi.nlm.nih.gov/36894559/ | |
| bis-ANS | 4,4’-dianilino-1,1’-binaphthyl-5,5’-disulfonic acid | No | TDP-43 Low complexity domain (TDP-43 LCD) in vitro condensates | TDP-43 LCD | non-polar cavities | Inducer; Dissolver | small molecule | https://pubmed.ncbi.nlm.nih.gov/33149109/ | |
| ANS | No | TDP-43 Low complexity domain (TDP-43 LCD) in vitro condensates | TDP-43 LCD | Inducer | small molecule | https://pubmed.ncbi.nlm.nih.gov/33149109/ | |||
| AmNS | No | TDP-43 Low complexity domain (TDP-43 LCD) in vitro condensates | TDP-43 LCD | Inducer | small molecule | https://pubmed.ncbi.nlm.nih.gov/33149109/ | |||
| SNS | No | TDP-43 Low complexity domain (TDP-43 LCD) in vitro condensates | TDP-43 LCD | Inducer | small molecule | https://pubmed.ncbi.nlm.nih.gov/33149109/ | |||
| Congo Red | No | TDP-43 Low complexity domain (TDP-43 LCD) in vitro condensates | TDP-43 LCD | amyloids | Inducer; Dissolver | small molecule | https://pubmed.ncbi.nlm.nih.gov/33149109/ | ||
| bis-ANS | 4,4’-dianilino-1,1’-binaphthyl-5,5’-disulfonic acid | No | FUS Low complexity domain (FUS LCD) in vitro condensates | FUS LCD | non-polar cavities | Inducer; Dissolver | small molecule | https://pubmed.ncbi.nlm.nih.gov/33149109/ | |
| bis-ANS | 4,4’-dianilino-1,1’-binaphthyl-5,5’-disulfonic acid | No | Ded1p in vitro condensates | Ded1p | non-polar cavities | Inducer; Dissolver | small molecule | https://pubmed.ncbi.nlm.nih.gov/33149109/ | |
| bis-ANS | 4,4’-dianilino-1,1’-binaphthyl-5,5’-disulfonic acid | No | Tau in vitro condensates | Tau | non-polar cavities | Inducer; Dissolver | small molecule | https://pubmed.ncbi.nlm.nih.gov/33149109/ | |
| bis-ANS | 4,4’-dianilino-1,1’-binaphthyl-5,5’-disulfonic acid | No | Stress granules | G3BP1 | non-polar cavities | Morpher | small molecule | https://pubmed.ncbi.nlm.nih.gov/33149109/ | |
| Tannic acid | TA | No | Tau in vitro condensates | Tau | unknown | Inducer; Dissolver | natural product | Alzheimer's disease | https://pubmed.ncbi.nlm.nih.gov/38960272/ |
| 1c | No | Tau/Zn in vitro condensates | Tau | Dissolver | small molecule | Alzheimer's disease | https://pubmed.ncbi.nlm.nih.gov/36471564/ | ||
| 1c | No | Tau in vitro condensates | Tau | Dissolver | small molecule | Alzheimer's disease | https://pubmed.ncbi.nlm.nih.gov/36471564/ | ||
| VX-670 | No | CUG repeat foci | MBNL1 | CUG repeat | Localizer | oligonucleotide | Myotonic dystrophy type 1 (DM1) | https://www.vrtx.com/our-science/rd-pipeline/myotonic-dystrophy-type-1/ | |
| PGN-EDODM1 | No | CUG repeat foci | CUG repeats; MBNL1 | CUG repeat | Dissolver | oligonucleotide | Myotonic dystrophy type 1 (DM1) | https://investors.pepgen.com/static-files/97ab01d2-7373-4220-899b-249ce5a6bc03 | |
| 25-hydroxycholesterol | 25-HC | No | CRYAB bodies | CRYAB R120G mutant | Dissolver | small molecule | Ischemic cardioomyopathy (ICM) | https://www.biorxiv.org/content/10.1101/2024.08.30.610556v1 | |
| Nocodazole | No | Tau cytoplasmic clusters | Tau | Tubulin | Inducer | small molecule | Alzheimer's disease | https://pubmed.ncbi.nlm.nih.gov/39032487/ | |
| HHS-166 | No | Stress granules | G3BP1 | G3BP1 | Dissolver | small molecule | https://pubmed.ncbi.nlm.nih.gov/37159397/ | ||
| AHL-030 | No | P bodies | EDC4 | EDC3 | Dissolver | small molecule | https://pubmed.ncbi.nlm.nih.gov/37159397/ | ||
| AHL-030 | No | Stress granules | G3BP1 | EDC3 | Inducer | small molecule | https://pubmed.ncbi.nlm.nih.gov/37159397/ | ||
| Nexturastat A | No | phospho-HDAC6 condensates | phospho HDAC6 | HDAC | Dissolver | small molecule | Triple-negative breast cancer (TNBC) | https://pubmed.ncbi.nlm.nih.gov/39198689/ | |
| Harmine | No | Cajal bodies | Coilin; SMN | Amine oxidase A | Dissolver | natural product | https://pubmed.ncbi.nlm.nih.gov/39258320/ | ||
| 5 | No | Stress granules | G3BP1; FUS R495X | ERα; FKBP12 | Dissolver | small molecule | Amyotrophic lateral sclerosis (ALS) | https://pubmed.ncbi.nlm.nih.gov/39294374/ | |
| LL-III | No | Synuclein in vitro condensates | αSynuclein | multiple | Inducer | peptide | Parkinson's disease (PD) | https://pubmed.ncbi.nlm.nih.gov/34165838/ | |
| GCTR | No | Tau in vitro condensates | Tau | Tau protofibrils | Dissolver | small molecule | Alzheimer's disease (AD) | https://pubmed.ncbi.nlm.nih.gov/38507972/ | |
| Nocodazole | No | Negri bodies | RABV-N | Tubulin | Dissolver | small molecule | Rabies virus (RABV) infection | https://pubmed.ncbi.nlm.nih.gov/28680096/ | |
| 6xCTG | No | CUG repeat RNA in vitro condensates | CUG repeat RNA | CUG repeat RNA | Dissolver | oligonucleotide | |||
| Doxorubicin | Yes | CAG repeat RNA in vitro condensates; CAG repeat RNA nuclear condensates; CUG repeat RNA nuclear condensates | CAG repeart RNA | DNA topoisomerase II | Dissolver | small molecule | Huntington's disease (HD); spinocerebellar ataxis (SCA); Myotonic dystrophy (DM1) | https://pubmed.ncbi.nlm.nih.gov/28562589/ | |
| ACI-6677 | No | TDP-43 in vitro condensates; pTDP-43 inclusions | TDP-43 | TDP-43 | Dissolver | monoclonal antibody | Amytrophic Lateral Sclerosis (ALS); frontotemporal lobar degeneration with TDP-43 pathology (FTLD-TDP) | https://pubmed.ncbi.nlm.nih.gov/39363348/ | |
| Cisplatin | Yes | Stress granules | G3BP1; TIA1; Caprin1 | DNA | Inducer | small molecule | Drug cytotoxicity | https://pubmed.ncbi.nlm.nih.gov/39575153/ | |
| Oligodeoxynucleotides | ODNs | No | TDP-43 cytoplasmic condensates | TDP-43 | unknown | Inducer | oligonucleotide | Amytrophic Lateral Sclerosis (ALS); frontotemporal lobar degeneration (FTLD) | https://pubmed.ncbi.nlm.nih.gov/39551138/ |
| SMQ-03-20 | No | PDE11A condensates | PDE11A4 | PDE11 | Dissolver | small molecule | Age-related cognitive decline | https://www.biorxiv.org/content/10.1101/2024.10.01.616004v1 | |
| Tadalafil | Yes | PDE11A condensates | PDE11A4 | PDE11 | Dissolver | small molecule | Age-related cognitive decline | https://www.biorxiv.org/content/10.1101/2024.10.01.616004v1 | |
| BC11-37 | No | PDE11A condensates | PDE11A4 | PDE11 | Dissolver | small molecule | Age-related cognitive decline | https://www.biorxiv.org/content/10.1101/2024.10.01.616004v1 | |
| SMQ-2-057 | No | PDE11A condensates | PDE11A4 | PDE11 | Dissolver | small molecule | Age-related cognitive decline | https://www.biorxiv.org/content/10.1101/2024.10.01.616004v1 | |
| SMQ-3-030 | No | PDE11A condensates | PDE11A4 | PDE11 | Dissolver | small molecule | Age-related cognitive decline | https://www.biorxiv.org/content/10.1101/2024.10.01.616004v1 | |
| Rapamycin | Yes | Stress granules | RIN | FK506-binding protein 1A | Dissolver | natural product | Traumatic brain injury (TBI) | https://pubmed.ncbi.nlm.nih.gov/29432563/ | |
| Rapamycin | Yes | Stress granules | p-TDP-43; TIAR | FK506-binding protein 1A | Dissolver | natural product | Amytrophic Lateral Sclerosis (ALS) | Amytrophic Lateral Sclerosis (ALS) | |
| Rapamycin | Yes | p62 bodies | p62 | FK506-binding protein 1A | Dissolver | natural product | Amytrophic Lateral Sclerosis (ALS) | https://pubmed.ncbi.nlm.nih.gov/39536963/ | |
| Sevoflurane | Yes | stress granules | hnRNPA2/B1 | RUVBL2 | Inducer | small molecule | Perioperative neurocognitive disorders (PND) | https://pubmed.ncbi.nlm.nih.gov/39610020/ | |
| Fluspirilene | No | Stress granules | G3BP1 | NADH | Localizer | small molecule | SARS-CoV-2 | https://pubmed.ncbi.nlm.nih.gov/39708056/ | |
| WIN-62577 | No | Stress granules | G3BP1 | muscarinic acetylcholine receptor | Localizer | small molecule | SARS-CoV-2 | https://pubmed.ncbi.nlm.nih.gov/39708056/ | |
| PROTAC (Proteolysis Targeting Chimera) degrader 129 | PT-129 | No | Stress granules | G3BP1 | G3BP1 | Dissolver | small molecule | Cancer | https://pubmed.ncbi.nlm.nih.gov/39710983/ |
| #129 | No | Stress granules | G3BP1 | G3BP1 | Dissolver | small molecule | Cancer | https://pubmed.ncbi.nlm.nih.gov/39710983/ | |
| Triangular prism-shaped DNA nanostructure containing polythymidine | ΔDNA(polyT) | No | In vitro reconstituted stress granules | G3BP1 | mRNAs | Inducer | nanodevice | https://pubmed.ncbi.nlm.nih.gov/39704478/ | |
| Titanium dioxide nanoparticles | TiO2 NPs | Yes | Stress granules | G3BP1; RACK1 | blood-testis barrier (BTB) | Dissolver | natural product | Reproductive toxicity | https://pubmed.ncbi.nlm.nih.gov/39709656/ |
| FOXM1-interfering peptides | FIPs | No | FOXM1 condensates | FOXM1 | FOXM1 | Dissolver | peptide | Breast cancer | https://pubmed.ncbi.nlm.nih.gov/39814884/ |
| Forsythoside B | FTSB | No | α-Syn condensates | α-Syn | α-Syn aggregates | Dissolver | natural product | Parkinson's disease (PD) | https://pubmed.ncbi.nlm.nih.gov/39818366/ |
| Echinacoside | ECH | No | α-Syn condensates | α-Syn | TGF beta signaling pathway | Dissolver | natural product | Parkinson's disease (PD) | https://pubmed.ncbi.nlm.nih.gov/39818366/ |
| PARP14i | No | Stress granules | G3BP1|RACK1 | MARylation of RACK1 | Dissolver | small molecule | Ovarian cancer | https://pubmed.ncbi.nlm.nih.gov/39760726/ | |
| Graphene Quantum Dots | GQDs | No | Stress granules | TDP-43 | TDP-43 | Dissolver | small molecule | Amytrophic Lateral Sclerosis (ALS) | https://pubmed.ncbi.nlm.nih.gov/39901566/ |
| Cysteine Au nanospheres | Cys AuNPs | No | Stress granules | G3BP1 | unknown | Inducer | other | https://pubmed.ncbi.nlm.nih.gov/39862843/ | |
| L-cysteine Au nanospheres | L-Cys AuNPs | No | Stress granules | G3BP1 | unknown | Inducer | other | https://pubmed.ncbi.nlm.nih.gov/39862843/ | |
| D-cysteine Au nanospheres | D-Cys AuNPs | No | Stress granules | G3BP1 | unknown | Inducer | other | https://pubmed.ncbi.nlm.nih.gov/39862843/ | |
| Penicillamine Au nanospheres | Pen AuNPs | No | Stress granules | G3BP1 | unknown | Inducer | other | https://pubmed.ncbi.nlm.nih.gov/39862843/ | |
| L-penicillamine Au nanospheres | L-pen AuNPs | No | Stress granules | G3BP1 | unknown | Inducer | other | https://pubmed.ncbi.nlm.nih.gov/39862843/ | |
| D-penicillamine Au nanospheres | D-pen AuNPs | No | Stress granules | G3BP1 | unknown | Inducer | other | https://pubmed.ncbi.nlm.nih.gov/39862843/ | |
| Histidine Au nanospheres | His AuNPs | No | Stress granules | G3BP1 | unknown | Inducer | other | https://pubmed.ncbi.nlm.nih.gov/39862843/ | |
| L-histidine Au nanospheres | L-his AuNPs | No | Stress granules | G3BP1 | unknown | Inducer | other | https://pubmed.ncbi.nlm.nih.gov/39862843/ | |
| D-histidine Au nanospheres | D-his AuNPs | No | Stress granules | G3BP1 | unknown | Inducer | other | https://pubmed.ncbi.nlm.nih.gov/39862843/ | |
| Cisplatin | Yes | Stress granules | G3BP1 | DNA | Inducer | other | https://pubmed.ncbi.nlm.nih.gov/39862843/ | ||
| L-penicillamine Au nanospheres | L-pen AuNPs | No | Cisplatin-induced stress granules | G3BP1 | unknown | Inducer | other | https://pubmed.ncbi.nlm.nih.gov/39862843/ | |
| D-penicillamine Au nanospheres | D-pen AuNPs | No | Cisplatin-induced stress granules | G3BP1 | unknown | Dissolver | other | https://pubmed.ncbi.nlm.nih.gov/39862843/ | |
| perillaldehyde | PAE | No | Stress granules | G3BP1 | G3BP1/2 | Inducer | natural product | Parkinson's disease (PD) | https://pubmed.ncbi.nlm.nih.gov/39951026/ |
| Z9 | No | Viral replication compartment | TSWV N-protein | TSWV N-protein | Dissolver | small molecule | tomato spotted wilt virus (TSWV) | https://pubmed.ncbi.nlm.nih.gov/40016246/ | |
| G3BP1 190-208 CPP | No | Stress granules | G3BP1; TIA1 | G3BP1 | Dissolver | peptide | Nerve injury | https://pubmed.ncbi.nlm.nih.gov/40014573/ | |
| Quercetin | QC | No | Stress granules | HIV-1 gp120 | reactive oxygen species (ROS) | Dissolver | natural product | HIV-associated neurocognitive disorders | https://pubmed.ncbi.nlm.nih.gov/40031974/ |
| Sorafenib | SOR | yes | Stress granules in Huh7 cell lines with p53 Y220C missense mutations | G3BP1; eIF4E; PABP | Kinases | Inducer | small molecule | Hepatocellular carcinoma (HCC) | Hepatocellular carcinoma (HCC) |
| Sorafenib | SOR | yes | Stress granules in SNU449 cell lines with p53 A161T missense mutations | G3BP1; eIF4E; PABP | Kinases | Inducer | small molecule | Hepatocellular carcinoma (HCC) | https://pubmed.ncbi.nlm.nih.gov/40064891/ |
| Sorafenib | SOR | yes | Stress granules in SNU475 cell lines with p53 G262A missense mutations | G3BP1 | Kinases | Inducer | small molecule | Hepatocellular carcinoma (HCC) | https://pubmed.ncbi.nlm.nih.gov/40064891/ |
| Sorafenib | SOR | yes | Stress granules in Hep3B cell lines with p53 null mutations | G3BP1 | Kinases | Inducer | small molecule | Hepatocellular carcinoma (HCC) | https://pubmed.ncbi.nlm.nih.gov/40064891/ |
| Sorafenib | SOR | yes | Stress granules in PLC/PRF/5 cell lines with p53 R249S missense mutations | G3BP1 | Kinases | Inducer | small molecule | Hepatocellular carcinoma (HCC) | https://pubmed.ncbi.nlm.nih.gov/40064891/ |
| Sorafenib | SOR | yes | Stress granules in HepG2 cell lines | G3BP1 | Kinases | Inducer | small molecule | Hepatocellular carcinoma (HCC) | https://pubmed.ncbi.nlm.nih.gov/40064891/ |
| Sorafenib | SOR | yes | Stress granules in TOV112D cell lines with p53 R175H missense mutations | G3BP1 | Kinases | Inducer | small molecule | Hepatocellular carcinoma (HCC) | https://pubmed.ncbi.nlm.nih.gov/40064891/ |
| Thapsigargin | TG | no | Stress granules in Huh7 cell lines with p53 Y220C missense mutations | G3BP1 | Sarco-endoplasmic reticulum Ca2+-ATPase (SERCA) | Inducer | natural product | Hepatocellular carcinoma (HCC) | https://pubmed.ncbi.nlm.nih.gov/40064891/ |
| Thapsigargin | TG | no | Stress granules in SNU449 cell lines with p53 A161T missense mutations | G3BP1 | Sarco-endoplasmic reticulum Ca2+-ATPase (SERCA) | Inducer | natural product | Hepatocellular carcinoma (HCC) | https://pubmed.ncbi.nlm.nih.gov/40064891/ |
| Thapsigargin | TG | no | Stress granules in PLC/PRF/5 cell lines with p53 R249S missense mutations | G3BP1 | Sarco-endoplasmic reticulum Ca2+-ATPase (SERCA) | Inducer | natural product | Hepatocellular carcinoma (HCC) | https://pubmed.ncbi.nlm.nih.gov/40064891/ |
| Thapsigargin | TG | no | Stress granules in SNU475 cell lines with p53 G262A missense mutations | G3BP1 | Sarco-endoplasmic reticulum Ca2+-ATPase (SERCA) | Inducer | natural product | Hepatocellular carcinoma (HCC) | https://pubmed.ncbi.nlm.nih.gov/40064891/ |
| Thapsigargin | TG | no | Stress granules in Hep3B cell lines with p53 null mutations | G3BP1 | Sarco-endoplasmic reticulum Ca2+-ATPase (SERCA) | Inducer | natural product | Hepatocellular carcinoma (HCC) | https://pubmed.ncbi.nlm.nih.gov/40064891/ |
| Thapsigargin | TG | no | Stress granules in TOV112D cell lines with p53 R175H missense mutations | G3BP1 | Sarco-endoplasmic reticulum Ca2+-ATPase (SERCA) | Inducer | natural product | Hepatocellular carcinoma (HCC) | https://pubmed.ncbi.nlm.nih.gov/40064891/ |
| Thapsigargin | TG | no | Stress granules in KHOS/NP cell lines with p53 R156P missense mutations | G3BP1 | Sarco-endoplasmic reticulum Ca2+-ATPase (SERCA) | Inducer | natural product | Hepatocellular carcinoma (HCC) | https://pubmed.ncbi.nlm.nih.gov/40064891/ |
| Thapsigargin | TG | no | Stress granules in U2OS cell lines | G3BP1 | Sarco-endoplasmic reticulum Ca2+-ATPase (SERCA) | Inducer | natural product | Hepatocellular carcinoma (HCC) | https://pubmed.ncbi.nlm.nih.gov/40064891/ |
| Thapsigargin | TG | no | Stress granules in SJSA1 cell lines | G3BP1 | Sarco-endoplasmic reticulum Ca2+-ATPase (SERCA) | Inducer | natural product | Hepatocellular carcinoma (HCC) | https://pubmed.ncbi.nlm.nih.gov/40064891/ |
| Thapsigargin | TG | no | Stress granules in OSC19 cell lines with p53 null mutations | G3BP1 | Sarco-endoplasmic reticulum Ca2+-ATPase (SERCA) | Inducer | natural product | Hepatocellular carcinoma (HCC) | https://pubmed.ncbi.nlm.nih.gov/40064891/ |
| Vincristine | VCR | yes | Stress granules in Huh7 cell lines with p53 Y220C missense mutations | G3BP1 | Tubulin | Inducer | small molecule | Hepatocellular carcinoma (HCC) | https://pubmed.ncbi.nlm.nih.gov/40064891/ |
| Vincristine | VCR | yes | Stress granules in SNU475 cell lines with p53 G262A missense mutations | G3BP1 | Tubulin | Inducer | small molecule | Hepatocellular carcinoma (HCC) | https://pubmed.ncbi.nlm.nih.gov/40064891/ |
| Vincristine | VCR | yes | Stress granules in Hep3B cell lines with p53 null mutations Stress granules in Hep3B cell lines with p53 null mutations | G3BP1 | Tubulin | Inducer | small molecule | Hepatocellular carcinoma (HCC) | https://pubmed.ncbi.nlm.nih.gov/40064891/ |
| Vincristine | VCR | yes | Stress granules in KHOS/NP cell lines with p53 R156P missense mutations | G3BP1 | Tubulin | Inducer | small molecule | Hepatocellular carcinoma (HCC) | https://pubmed.ncbi.nlm.nih.gov/40064891/ |
| Vincristine | VCR | yes | Stress granules in U2OS cell lines | G3BP1 | Tubulin | Inducer | small molecule | Hepatocellular carcinoma (HCC) | https://pubmed.ncbi.nlm.nih.gov/40064891/ |
| Vincristine | VCR | yes | Stress granules in HN31 cell lines with p53 C176F missense mutations | G3BP1 | Tubulin | Inducer | small molecule | Hepatocellular carcinoma (HCC) | https://pubmed.ncbi.nlm.nih.gov/40064891/ |
| Tilfrinib | no | HNRNPH1 condensates | HNRNPH1 | Brk/PTK6 | Dissolver | small molecule | Colorectal cancer (CRC) | https://pubmed.ncbi.nlm.nih.gov/40103198/ | |
| ML324 | no | PABPC1 condensates | PABPC1; eIF4G | matrix metalloprotease (MMP)37 ; histone demethylase 4 (KDM4) | Dissolver | small molecule | Chronic myeloid leukaemia (CML) | https://pubmed.ncbi.nlm.nih.gov/40102686/ | |
| 1,10-Phen | no | PABPC1 condensates | PABPC1; eIF4G | matrix metalloprotease (MMP)37 ; histone demethylase 4 (KDM4) | Dissolver | small molecule | Chronic myeloid leukaemia (CML) | https://pubmed.ncbi.nlm.nih.gov/40102686/ | |
| (− )-Gallocatechin gallate | GCG | No | SARS-CoV-2 Nucleocapsid condensates|SARS-CoV-2 Nucleocapsid in vitro reconstituted condensates | SARS-CoV2 nucleocapsid | Bcl-2 ; HIV integrase | Dissolver | natural compound | COVID | https://pubmed.ncbi.nlm.nih.gov/40086356/ |
| Tubercidin | no | Nuclear speckles | SC35 | DNA | Inducer | small molecule | Cardiotoxicity | https://pubmed.ncbi.nlm.nih.gov/40121465/ | |
| ARV-771 | no | FOXP1 condensates | FOXP1 | BET family | Morpher | small molecule | Small cell lung cancer (SCLC) | https://pubmed.ncbi.nlm.nih.gov/40082538/ | |
| Cisplatin | yes | FOXP1 condensates | FOXP1 | DNA | Morpher | small molecule | Small cell lung cancer (SCLC) | https://pubmed.ncbi.nlm.nih.gov/40082538/ | |
| Etoposide | yes | FOXP1 condensates | FOXP1 | topoisomerase II | Morpher | small molecule | Small cell lung cancer (SCLC) | https://pubmed.ncbi.nlm.nih.gov/40082538/ | |
| Talazoparib | yes | FOXP1 condensates | FOXP1 | PARP | Morpher | small molecule | Small cell lung cancer (SCLC) | https://pubmed.ncbi.nlm.nih.gov/40082538/ | |
| 17AGG | no | Stress granules | G3BP1; PABP | HSP90 | Dissolver | small molecule | Head and neck cancer (HNC) | https://pubmed.ncbi.nlm.nih.gov/40114316/ | |
| Cisplatin | yes | Stress granules | G3BP1; PABP | DNA | Inducer | small molecule | Head and neck cancer (HNC) | https://pubmed.ncbi.nlm.nih.gov/40114316/ | |
| GSK8612 | no | Stress granules | G3BP1; PABP | TBK1 | Dissolver | small molecule | Head and neck cancer (HNC) | https://pubmed.ncbi.nlm.nih.gov/40114316/ | |
| FIP4 | FOXM1‐interfering peptide 4 | no | FOXM1 condensates | FOXM1 | FOXM1 | Dissolver | peptide | Breast cancer | https://pubmed.ncbi.nlm.nih.gov/39814884/ |
| Hydrogen sulfide | H2S | no | Stress granules | G3BP1 | N/A | Inducer | small molecule | Hydrogen sulfide respiratory damage | https://pubmed.ncbi.nlm.nih.gov/40202609/ |
| Pyridoxal hydrochloride | no | Stress granules | G3BP1 | N/A | Dissolver | small molecule | Stress-related skin disorders | https://pubmed.ncbi.nlm.nih.gov/40216204/ | |
| Mitoxantrone | Mito | yes | Stress granules | G3BP1 | DNA | Dissolver | small molecule | Amyotrophic Lateral Sclerosis (ALS) | https://pubmed.ncbi.nlm.nih.gov/40284406/ |
| RBM20 antisense oligonucleotides | RBM20-ASOs | no | RBM20 condensates | RBM20 | RBM20 | Dissolver | oligonucleotide | Dilated cardiomyopathy (DCM) | https://pubmed.ncbi.nlm.nih.gov/40242865/ |
| 4-Amino-3',4'-dihydroxychalcone | 4-ADHC | no | Tau condensates | Tau | Tau | Morpher | small molecule | Alzheimer's disease; frontotemporal dementia (FTD) | https://pubmed.ncbi.nlm.nih.gov/40226980/ |
| Cisplatin | yes | Stress granules | G3BP1 | DNA | Inducer | small molecule | Drug resistance | https://pubmed.ncbi.nlm.nih.gov/40247038/ | |
| Cisplatin | yes | P-body | DDX6 | DNA | Dissolver | small molecule | Drug resistance | https://pubmed.ncbi.nlm.nih.gov/40247038/ | |
| Cycloheximide | CHX | yes | Stress granules | G3BP1 | FK506-binding protein 1A | Inducer | small molecule | Drug resistance | https://pubmed.ncbi.nlm.nih.gov/40247038/ |
| Cycloheximide | CHX | yes | P-body | DDX6 | FK506-binding protein 1A | Dissolver | small molecule | Drug resistance | https://pubmed.ncbi.nlm.nih.gov/40247038/ |
| Pyrvinium | yes | Stress granules | G3BP1 | CK1 | Inducer | small molecule | Drug resistance | https://pubmed.ncbi.nlm.nih.gov/40247038/ | |
| Pyrvinium | yes | P-body | DDX6 | CK1 | Dissolver | small molecule | Drug resistance | https://pubmed.ncbi.nlm.nih.gov/40247038/ | |
| Cadmium(II) | no | PML body | PML | unknown | Localizer | other | Cancer | https://pubmed.ncbi.nlm.nih.gov/40243484/ | |
| Cobalt(II) | no | PML body | PML | unknown | Localizer | other | Cancer | https://pubmed.ncbi.nlm.nih.gov/40243484/ | |
| Chromium(III) | no | PML body | PML | unknown | Localizer | other | Cancer | https://pubmed.ncbi.nlm.nih.gov/40243484/ | |
| Integrated Stress Response Inhibitor | ISRIB | no | Stress granules | G3BP1 | eIF2B | Dissolver | small molecule | Prolactinoma | https://pubmed.ncbi.nlm.nih.gov/40281543/ |
| L-7 | no | Stress granules | G3BP1 | G3BP1 | Dissolver | small molecule | Chikungunya virus | https://pubmed.ncbi.nlm.nih.gov/40306108/ | |
| WIN | no | Stress granules | G3BP1 | G3BP1 | Dissolver | small molecule | Chikungunya virus | https://pubmed.ncbi.nlm.nih.gov/40306108/ | |
| SB2 | no | Stress granules | G3BP1 | G3BP1 | Dissolver | small molecule | Chikungunya virus | https://pubmed.ncbi.nlm.nih.gov/40306108/ | |
| NAL | no | Stress granules | G3BP1 | G3BP1 | Dissolver | small molecule | Chikungunya virus | https://pubmed.ncbi.nlm.nih.gov/40306108/ | |
| DHD | no | Stress granules | G3BP1 | G3BP1 | Dissolver | small molecule | Chikungunya virus | https://pubmed.ncbi.nlm.nih.gov/40306108/ | |
| GSK | no | Stress granules | G3BP1 | G3BP1 | Dissolver | small molecule | Chikungunya virus | https://pubmed.ncbi.nlm.nih.gov/40306108/ | |
| FLU | no | Stress granules | G3BP1 | G3BP1 | Dissolver | small molecule | Chikungunya virus | https://pubmed.ncbi.nlm.nih.gov/40306108/ | |
| Ponceau S | no | Condensates | Ponceau S | BSA | Inducer | small molecule | https://pubmed.ncbi.nlm.nih.gov/40353860/ | ||
| Ponceau S | no | Condensates | Ponceau S | Lysozyme | Inducer | small molecule | https://pubmed.ncbi.nlm.nih.gov/40353860/ | ||
| Sennoside A | no | Sennoside A | Nucleocapsid | Nucleocapsid | Dissolver | natural product | COVID | https://pubmed.ncbi.nlm.nih.gov/40371698/ | |
| Sennoside B | no | SARS-CoV-2 Nucleocapsid condensates|SARS-CoV-2 Nucleocapsid in vitro reconstituted condensates | Nucleocapsid | Nucleocapsid | Dissolver | natural product | COVID | https://pubmed.ncbi.nlm.nih.gov/40371698/ | |
| Lipoamide | no | Stress granules | FUS| G3BP1| PABPC1| TIAL1| EWSR1 | SFPQ | Dissolver | small molecule | amyotrophic lateral sclerosis (ALS) | https://pubmed.ncbi.nlm.nih.gov/40369342/ | |
| Polydeoxyribonucleotide | PDRN | no | Stress granules | G3BP1 | LC3 | Dissolver | oligonucleotide | Skin aging | https://pubmed.ncbi.nlm.nih.gov/40343916/ |
| Veliparib | No | DNA damage foci | γH2AX | PARP | Inducer | small molecule | Drug resistance | https://pubmed.ncbi.nlm.nih.gov/36849518/ | |
| Chloroquine | yes | αSyn inclusions | αSyn | Toll-like receptor 9 | Dissolver | small molecule | Parkinson’s disease (PD) | https://pubmed.ncbi.nlm.nih.gov/40317721/ | |
| Cisplatin | yes | Nucleolus | NPM1|Fibrillarin | DNA | Morpher | small molecule | Cancer | https://pubmed.ncbi.nlm.nih.gov/40391829/ | |
| Oxaliplatin | yes | Nucleolus | NPM1|Fibrillarin | DNA | Morpher | small molecule | Cancer | https://pubmed.ncbi.nlm.nih.gov/40391829/ | |
| Actinomycin D | ActD | yes | Nucleolus | NPM1|Fibrillarin | DNA | Morpher | small molecule | Cancer | https://pubmed.ncbi.nlm.nih.gov/40391829/ |
| 1R, 2R DACH Pt | no | Nucleolus | NPM1|Fibrillarin | DNA | Morpher | small molecule | Cancer | https://pubmed.ncbi.nlm.nih.gov/40391829/ | |
| 1R, 2R Penta Pt | no | Nucleolus | NPM1|Fibrillarin | DNA | Morpher | small molecule | Cancer | https://pubmed.ncbi.nlm.nih.gov/40391829/ | |
| 16–19F | no | Stress granules | G3BP1|MCM7 | PRMT5 | Inducer | small molecule | MTAP-deleted cancer | https://pubmed.ncbi.nlm.nih.gov/40440106/ | |
| Natamycin | yes | FfSR condensates | FfSR | Ergosterol | Dissolver | small molecule | Rice bakanae disease | https://pubmed.ncbi.nlm.nih.gov/40514608/ | |
| Coumermycin A1 | no | Stress granules | RABV|TIAR | DNA gyrase | Inducer | small molecule | Rabies virus (RABV) | https://pubmed.ncbi.nlm.nih.gov/36069552/ | |
| Olaparib | yes | USP49 condensates | USP49|RAP70|Rad51 | PARP | Inducer | small molecule | Radioresistance|Esophageal squamous cell carcinoma (ESCC) | https://pubmed.ncbi.nlm.nih.gov/40460957/ | |
| Abroquinone | AQ | no | β-catenin condensates | β-catenin | β-catenin | Inducer | small molecule | Liver cancer | https://pubmed.ncbi.nlm.nih.gov/40593772/ |
| Salvianolic acid C | SAC | No | YTHDF1 condensates | YTHDF1|FMRP | YTHDF1 | Dissolver | small molecule | Fragile X syndrome (FXS) | https://pubmed.ncbi.nlm.nih.gov/37949069/ |
| KI-DX-014 | no | DDX21 condensates | DDX21 | DDX21 | Dissolver | small molecule | Cancer|Neurodegeneration | https://pubmed.ncbi.nlm.nih.gov/40637641/ | |
| Nilotinib | yes | WDR3 condensates | WDR3 | Bcr-Abl|ABL | Dissolver | small molecule | Osteosarcoma | https://pubmed.ncbi.nlm.nih.gov/40646517/ | |
| WNK463 | no | MxA condensates | MxA | WNK1 | Inducer | small molecule | Oral cancer | https://pubmed.ncbi.nlm.nih.gov/40643468/ | |
| WNK-IN-11 | no | MxA condensates | MxA | WNK1-4 | Morpher | small molecule | Oral cancer | https://pubmed.ncbi.nlm.nih.gov/40643468/ | |
| Closantel | no | MxA condensates | MxA | SPAK/OSR1 | Dissolver | small molecule | Oral cancer | https://pubmed.ncbi.nlm.nih.gov/40643468/ | |
| T-025 | no | Nuclear speckles | SRSF7|SRSF2 | CLK | Inducer|Localizer|Morpher | small molecule | Triple-negative breast cancer (TNBC) | https://pubmed.ncbi.nlm.nih.gov/40731028/ | |
| 3b | no | α-Synuclein condensates | α-Synuclein | α-Synuclein | Dissolver | small molecule | Parkinson’s disease (PD) | https://pubmed.ncbi.nlm.nih.gov/40770610/ | |
| Rapamycin | yes | Stress granules | NCOA7|G3BP1|CAPRIN1 | FK506-binding protein 1A | Dissolver | small molecule | Ovarian aging | https://pubmed.ncbi.nlm.nih.gov/40745099/ | |
| N7 mRNA-LNP | no | Stress granules | NCOA7|G3BP1|CAPRIN1 | NCOA7 | Dissolver | RNA | Ovarian aging | https://pubmed.ncbi.nlm.nih.gov/40745099/ | |
| Sevoflurane | yes | Stress granules | hnRNPA2/B1|TIA1| | Serotonin 3a (5-Hta) receptor | Morpher|Localizer | small molecule | Neurotoxicity | https://pubmed.ncbi.nlm.nih.gov/40776395/ | |
| Pyrvinium pamoate | PP | yes | Nuclear speckles | SRSF2|SON | Androgen receptor | Morpher | small molecule | Proteinopathies | https://pubmed.ncbi.nlm.nih.gov/40764481/ |
| nCoV400Fab | no | SARS-CoV-2 Nucleocapsid condensates | SARS-CoV-2 Nucleocapsid | SARS-CoV-2 Nucleocapsid | Dissolver | small molecule | COVID | https://pubmed.ncbi.nlm.nih.gov/40830575/ | |
| Cisplatin | yes | Stress granules | G3BP1|TIAR | DNA | Inducer | small molecule | Osteosarcoma (OS) | https://pubmed.ncbi.nlm.nih.gov/40858563/ | |
| Doxorubicin | yes | Stress granules | G3BP1|TIAR | DNA topoisomerase II | Inducer | small molecule | Osteosarcoma (OS) | https://pubmed.ncbi.nlm.nih.gov/40858563/ | |
| Etoposide | yes | Stress granules | G3BP1|TIAR | DNA topoisomerase II | Inducer | small molecule | Osteosarcoma (OS) | https://pubmed.ncbi.nlm.nih.gov/40858563/ | |
| Methotrexate | yes | Stress granules | G3BP1|TIAR | Dihydrofolate reductase | Inducer | small molecule | Osteosarcoma (OS) | https://pubmed.ncbi.nlm.nih.gov/40858563/ | |
| Integrated stress response inhibitor | ISRIB | no | Stress granules | TIA1 | eIF2B | Inducer | small molecule | Neurodegenerative diseases | https://pubmed.ncbi.nlm.nih.gov/40887259/ |
| RK-33 | no | RNP granules | DDX3|G3BP1 | DDX3 | Morpher | small molecule | https://pubmed.ncbi.nlm.nih.gov/40863725/ | ||
| G4C2 C-ASO | no | RNA condensates | C-ASO | G4C2 repeat RNA | Dissolver | RNA | https://pubmed.ncbi.nlm.nih.gov/40840752/ | ||
| TD-interfering peptide | TIP | no | EML4-ALK condensates | EML4-ALK | EML4-ALK | Dissolver | peptide | Cancer | https://pubmed.ncbi.nlm.nih.gov/40875402/ |
| Tolcapone | yes | SARS-CoV-2 Nucleocapsid condensates | SARS-CoV-2 Nucleocapsid | catechol-O-methyltransferase (COMT) | Inducer | small molecule | COVID | https://pubmed.ncbi.nlm.nih.gov/34634033/ | |
| Nelfinavir mesylate | yes | SARS-CoV-2 Nucleocapsid condensates | SARS-CoV-2 Nucleocapsid | HIV protease inhibitor | Inducer | small molecule | COVID | https://pubmed.ncbi.nlm.nih.gov/34634033/ | |
| LDK378 | Ceritinib | yes | SARS-CoV-2 Nucleocapsid condensates | SARS-CoV-2 Nucleocapsid | tyrosine kinase inhibitor | Inducer | small molecule | COVID | https://pubmed.ncbi.nlm.nih.gov/34634033/ |
| Nilotinib | yes | SARS-CoV-2 Nucleocapsid condensates | SARS-CoV-2 Nucleocapsid | Bcr-Abl|ABL | Morpher | small molecule | COVID | https://pubmed.ncbi.nlm.nih.gov/34634033/ | |
| Chlorhexidine | yes | SARS-CoV-2 Nucleocapsid condensates | SARS-CoV-2 Nucleocapsid | bacterial cell walls | Inducer | small molecule | COVID | https://pubmed.ncbi.nlm.nih.gov/34634033/ | |
| Elvitegravir | yes | SRC-1 condensates | SRC1|BFP2|YAP | HIV-1 integrase | Dissolver | small molecule | Cancer | https://pubmed.ncbi.nlm.nih.gov/33850322/ | |
| Crystal Violet | no | SARS-CoV-2 Nucleocapsid condensates | SARS-CoV-2 Nucleocapsid | DNA | Inducer | small molecule | COVID | https://pubmed.ncbi.nlm.nih.gov/34634033/ | |
| Huezole | R-huezole | no | Tubulin condensates | Tubilin | Tubulin | Inducer | small molecule | https://pubmed.ncbi.nlm.nih.gov/35694339/ | |
| CVL218 | no | SARS-CoV-2 Nucleocapsid condensates | SARS-CoV-2 Nucleocapsid | PARP | Morpher | small molecule | COVID | https://pubmed.ncbi.nlm.nih.gov/33770364/ | |
| PJ34 | no | SARS-CoV-2 Nucleocapsid condensates | SARS-CoV-2 Nucleocapsid | PARP | Morpher | small molecule | COVID | https://pubmed.ncbi.nlm.nih.gov/33770364/ | |
| Integrated stress response inhibitor | Integrated stress response inhibitor | no | Stress granules | TIA1 | eIF2b | Inducer | small molecule | https://pubmed.ncbi.nlm.nih.gov/40887259/ | |
| RK-33 | no | RNP granules|Stress granules|P-bodies | G3BP1|DDX3 | DDX3 | Morpher|Localizer | small molecule | Cancer | https://pubmed.ncbi.nlm.nih.gov/40863725/ | |
| Salicylic acid | SA | yes | Nuclear speckles | ELF3 | ELF3 | Dissolver | small molecule | Plant thermomorphogenic growth | https://pubmed.ncbi.nlm.nih.gov/40913711/ |
| Licochalcone B | no | Stress granules | G3BP1|TIA1 | TACE | Dissolver|Morpher | small molecule | Acute lung injury (ALI) | https://pubmed.ncbi.nlm.nih.gov/40930288/ | |
| Gold nanoparticle–DNA | AuDNA | no | Stress granules | VEGF | Inducer | DNA | Cancer | https://pubmed.ncbi.nlm.nih.gov/40944981/ | |
| Doxorubicin | DOX | yes | ALYREF condensates | ALYREF | DNA topoisomerase II | Dissolver | small molecule | Cardiotoxicity|Drug-induced cardiotoxicity | https://pubmed.ncbi.nlm.nih.gov/40899520/ |
| CGX-635 | yes | Fibrillarin condensates | fibrillarin | fibrillarin | Inducer | small molecule | Acute Myeloid Leukemia (AML) | https://pubmed.ncbi.nlm.nih.gov/38745030/ | |
| Polyethyleneimine | PEI | no | RNA condensates | RNA | TGFβ1 mRNA | Inducer | small molecule | Breast cancer | https://pubmed.ncbi.nlm.nih.gov/36209170/ |
| Cyclodextrin-based polymer | cDex | no | RNA condensates | RNA | TGFβ1 mRNA | Inducer | small molecule | Breast cancer | https://pubmed.ncbi.nlm.nih.gov/36209170/ |
| Dextran polymer modified with diethylenetriamine | DETA-Dex | no | RNA condensates | RNA | TGFβ1 mRNA | Inducer | small molecule | Breast cancer | https://pubmed.ncbi.nlm.nih.gov/36209170/ |
| XS561 | no | Nur77 condensates | Nur77 | Nur77 | Inducer | small molecule | Breast cancer | https://pubmed.ncbi.nlm.nih.gov/38486987/ | |
| BI1071 | no | Nur77 condensates | Nur77 | Nur77 | Inducer | small molecule | Breast Cancer | https://pubmed.ncbi.nlm.nih.gov/38486987/ | |
| XL-3156 | no | cGAS foci | cGAS | cGAS | Dissolver|Morpher | small molecule | Leukemia | https://pubmed.ncbi.nlm.nih.gov/40461475/ | |
| XL-3158 | no | cGAS foci | cGAS | cGAS | Dissolver|Morpher | small molecule | Leukemia | https://pubmed.ncbi.nlm.nih.gov/40461475/ | |
| ZXH-3-26 | no | BRD4 condensates | BRD4 | BRD4 | Dissolver | small molecule | Cervical cancer | https://pubmed.ncbi.nlm.nih.gov/37156794/ | |
| CMP76 | no | Stress granules | G3BP1|hnRNPK|FXR1|Myc mRNA | Myc | Localizer | small molecule | Non-small cell lung carcinoma (NSCLC) | https://pubmed.ncbi.nlm.nih.gov/40943063/ |