Angewandte Chemie (International ed in English)
Science
bioRxiv
Multivalent interactions between eIF4G1, Pub1 and Pab1 drive the formation of protein condensates
bioRxiv
Hydration-dependent phase separation of a prion-like protein regulates seed germination during water stress.
Genes
The Impact of Coilin Nonsynonymous SNP Variants E121K and V145I on Cell Growth and Cajal Body Formation: The First Characterization
Soft Matter
Equilibrium size distribution and phase separation of multivalent, molecular assemblies in dilute solution
Bio-protocol
Studying Protein Aggregation in the Context of Liquid-liquid Phase Separation Using Fluorescence and Atomic Force Microscopy, Fluorescence and Turbidity Assays, and FRAP
bioRxiv
The emergence of phase separation as an organizing principle in bacteria
Neurochemistry international
Pathophysiological Implications of RNP Granules in Frontotemporal Dementia and ALS
Jill Bouchard
Contributing editor, Condensates.com
Here's a nice review on the biophysical properties of stress granules and paraspeckles in the hopes of finding a condensate-based therapy for neuodegenerative disorders.
Veterinary microbiology
Pseudorabies virus infection inhibits stress granules formation via dephosphorylating eIF2α
Jill Bouchard
Contributing editor, Condensates.com
Here's another virus that targets stress granules, and a close look at how it does it.
bioRxiv
Molecular details of protein condensates probed by microsecond-long atomistic simulations
bioRxiv
Liquid-liquid phase separation of tau driven by hydrophobic interaction facilitates fibrillization of tau
Nature chemistry
De novo engineering of intracellular condensates using artificial disordered proteins
Bioinformatics (Oxford, England)
IDRMutPred: predicting disease-associated germline nonsynonymous single nucleotide variants (nsSNVs) in intrinsically disordered regions
Jill Bouchard
Contributing editor, Condensates.com
Sometimes disease mutants make a big difference for condensate behavior. This tool might help find the important mutations to study out of the sea of possibilities.
The international journal of biochemistry & cell biology
“STRESSED OUT”: The Role of FUS and TDP-43 in Amyotrophic lateral sclerosis
Jill Bouchard
Contributing editor, Condensates.com
Understanding how these proteins gain cytoplasmic functions and lose nuclear functions may help us figure out how to target condensates to restore balance.
Acta neuropathologica
The role of hnRNPs in frontotemporal dementia and amyotrophic lateral sclerosis
Emerging topics in life sciences
Membraneless organelles: phasing out of equilibrium
BioRxiv
P-bodies are sites of rapid RNA decay during the neural crest epithelial—mesenchymal transition
Jill Bouchard
Contributing editor, Condensates.com
Here's one for the commonly debated question about the role of P bodies: these authors show they're sites for RNA decay.
Neuroscience letters
The effects of phospholipids and fatty acids on the oligomer formation of NAP-22
Jill Bouchard
Contributing editor, Condensates.com
It's always fun to see the intersection of phase separation and membranes. Here a membrane protein oligomerizes and ultimately phase separates due to specific lipids.
bioRxiv
Glycine Rich Segments Adopt Polyproline II Helices Which May Contribute to Biomolecular Condensate Formation
bioRxiv