bioRxiv
Science
Proceedings of the National Academy of Sciences of the United States of America
Glucocorticoid receptor condensates link DNA-dependent receptor dimerization and transcriptional transactivation
JCI insight
Characterization of HNRNPA1 mutations defines diversity in pathogenic mechanisms and clinical presentation
Biochemistry
Liquid-Liquid Phase Separation in Biology: Specific Stoichiometric Molecular Interactions vs Promiscuous Interactions Mediated by Disordered Sequences
The journal of physical chemistry letters
Interplay between Kinetics and Dynamics of Liquid-Liquid Phase Separation in a Protein Solution Revealed by Coherent X-ray Spectroscopy
Journal of the American Chemical Society
Different Folding States from the Same Protein Sequence Determine Reversible vs Irreversible Amyloid Fate
Jill Bouchard
Managing editor, Condensates.com
This work argues amyloids can be reversible and irreversible.
Journal of virology
EV71 2A Protease inhibits P-body formation to promote viral RNA synthesis
Jill Bouchard
Managing editor, Condensates.com
I see a lot of interesting work about the role of stress granules in viral infections. This work looks at P bodies. Check out this paper for a fresh take on condensates in infections.
The EMBO journal
Tudor staphylococcal nuclease is a docking platform for stress granule components and is essential for SnRK1 activation in Arabidopsis
Jill Bouchard
Managing editor, Condensates.com
We saw this paper come out on bioRxiv last year, and it's nice to see it published in EMBO J now! Check out our post about the original bioRxiv preprint here.
bioRxiv
Regulation of a bacterial histidine kinase by a phase separating scaffolding protein
Nature communications
High-depth spatial transcriptome analysis by photo-isolation chemistry
Jill Bouchard
Managing editor, Condensates.com
This looks to be a useful new method to detect genes expressed in condensates.
Biochimica et biophysica acta Molecular cell research
Liquid-liquid phase separation as a common organizing principle of intracellular space and biomembranes providing dynamic adaptive responses
Biochimica et Biophysica Acta Molecular Cell Research
M33 condenses chromatin through nuclear body formation and methylation of both histone H3 lysine 9 and lysine 27
Journal of the American Chemical Society
G-Quadruplex-Induced Liquid-Liquid Phase Separation in Biomimetic Protocells
Nature reviews Microbiology
Targeting viral liquid-liquid phase separation
Jill Bouchard
Managing editor, Condensates.com
Here's a In Brief article on two recent Nature papers about using drugs targeting condensates to fight viruses. Find links to them below: Nat Cell Biol paper about targeting LLPS in SARS-CoV-2 Nature paper about a condensate-hardening drug against RSV
Journal of molecular biology
Interplay between disordered regions in RNAs and proteins modulates interactions within stress granules and processing bodies
Cell research
A phosphatidic acid-binding lncRNA SNHG9 facilitates LATS1 liquid-liquid phase separation to promote oncogenic YAP signaling
Nature reviews Molecular cell biology
Targeting viruses in their phase
Jill Bouchard
Managing editor, Condensates.com
Here's the Research Highlight on two recent Nature papers about using drugs targeting condensates to fight viruses. Find links to them below: Nat Cell Biol paper about targeting LLPS in SARS-CoV-2 Nature paper about a condensate-hardening drug against RSV
Journal of molecular biology
Nuclear protein condensates and their properties in regulation of gene expression
Journal of molecular biology
The diverse functions of small heat shock proteins in the proteostasis network
Nature Communications