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Science

bioRxiv

Consistent Force Field Captures Homolog Resolved HP1 Phase Separation

  • Methods
  • Phase Separation
  • Physics of Condensates

bioRxiv

Physical theory of biological noise buffering by multi-component phase separation

  • Methods
  • Phase Separation
  • Physics of Condensates
  • Transcription

bioRxiv

Role of spatial patterning of N-protein interactions in SARS-CoV-2 genome packaging

  • COVID-19
  • Infectious Disease
  • Methods
  • Phase Separation
  • Physics of Condensates

Jill Bouchard

Contributing editor, Condensates.com

The authors looked into whether the arrangement of LLPS-promoting and solubilizing sequences in the genome lead to single genome packaging. Read on to learn about generalizable principles of virus compaction.

Biomacromolecules

Self-Assembly of Silk-like Protein into Nanoscale Bicontinuous Networks under Phase-Separation Conditions

  • Imaging
  • Methods
  • Phase Separation
  • Physics of Condensates

mSphere

Association of Zinc Finger Antiviral Protein Binding to Viral Genomic RNA with Attenuation of Replication of Echovirus 7

  • Infectious Disease
  • Transcription

Jill Bouchard

Contributing editor, Condensates.com

The authors implicate stress granules and potentially other cellular compartments in mediating antiviral effects.

Biomacromolecules

Nanoscopic Dynamics Dictate the Phase Separation Behavior of Intrinsically Disordered Proteins

  • Methods
  • Phase Separation
  • Physics of Condensates

RNA biology

Identification and initial characterization of POLIII-driven transcripts by msRNA-sequencing

  • Methods

Jill Bouchard

Contributing editor, Condensates.com

It looks like this msRNAseq method may be helpful in identifying medium-sized RNA in other condensates too.

Cells

Limited Proteolysis-Coupled Mass Spectrometry Identifies Phosphatidylinositol 4,5-Bisphosphate Effectors in Human Nuclear Proteome

  • Cancer
  • Methods
  • Phase Separation
  • Physics of Condensates

Jill Bouchard

Contributing editor, Condensates.com

Do lipids make it into condensates? This method seeks to uncover the complicated relationship between lipids and many proteins that localize to condensates.

bioRxiv

Deciphering how naturally occurring sequence features impact the phase behaviors of disordered prion-like domains

  • Methods
  • Neurodegeneration
  • Phase Separation
  • Physics of Condensates

Nature communications

p62/SQSTM1-droplet serves as a platform for autophagosome formation and anti-oxidative stress response

  • Cancer
  • Neurodegeneration
  • Phase Separation
  • Transcription

Jill Bouchard

Contributing editor, Condensates.com

Here's the 2nd paper that came out in the same day about p62 bodies. If you don't know much about them (no judging, I didn't either ;), these papers might help you get up to speed!

EMBO reports

MOAP-1-mediated dissociation of p62/SQSTM1 bodies releases Keap1 and suppresses Nrf2 signaling

  • Cancer
  • Phase Separation
  • Physics of Condensates
  • Transcription

Jill Bouchard

Contributing editor, Condensates.com

Have you heard about p62 bodies yet? This is the first of two papers published on the same day about them.

Langmuir : the ACS journal of surfaces and colloids

Bulk Phase Behavior vs Interface Adsorption: Specific Multivalent Cation and Anion Effects on BSA Interactions

  • Methods
  • Phase Separation
  • Physics of Condensates

The journal of physical chemistry B

Structure-Function Properties in Disordered Condensates

  • Phase Separation
  • Physics of Condensates

Jill Bouchard

Contributing editor, Condensates.com

It was nice to get a sneak peak of this work from Jeremy Schmit at his Kitchen Table Talk in the fall. Check out Jeremy's video here for a great supplement to this paper!

Frontiers in cell and developmental biology

Complex Interactions Between Membrane-Bound Organelles, Biomolecular Condensates and the Cytoskeleton

  • Phase Separation
  • Physics of Condensates

Trends in cell biology

Biomolecular Condensates at the Front: Cell Migration Meets Phase Separation

  • Neurodegeneration
  • Phase Separation
  • Physics of Condensates

bioRxiv

Overexpression of the microtubule-binding protein CLIP-170 induces a +TIP network superstructure consistent with a biomolecular condensate

  • Phase Separation
  • Physics of Condensates

Jill Bouchard

Contributing editor, Condensates.com

Cool, it looks like growing microtubules are regulated at least in part by the phase separation of plus-end tracking proteins (+TIPs).

bioRxiv

Interplay of folded domains and the disordered low-complexity domain in mediating hnRNPA1 phase separation

  • Methods
  • Phase Separation
  • Physics of Condensates
  • Transcription

Current opinion in cell biology

Noise buffering by biomolecular condensates in glucose sensing

  • Cancer
  • Metabolism
  • Neurodegeneration
  • Phase Separation

Journal of molecular cell biology

Observation of an α-synuclein liquid droplet state and its maturation into Lewy body-like assemblies

  • Neurodegeneration
  • Phase Separation
  • Physics of Condensates

Journal of molecular biology

Biochemical timekeeping via reentrant phase transitions

  • Methods
  • Phase Separation
  • Physics of Condensates
  • Transcription

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