Cell death & disease
Cellular fate of intersex differentiation
Jill Bouchard
Managing editor, Condensates.com
This paper shows that ovotestis infertility results from the proteasomes phase separating and causing female germline cells to be degraded.
Science
bioRxiv
Molecular determinants of phase separation for Drosophila DNA replication licensing factors
Nature communications
GCG inhibits SARS-CoV-2 replication by disrupting the liquid phase condensation of its nucleocapsid protein
Nucleic acids research
The rDNA is biomolecular condensate formed by polymer-polymer phase separation and is sequestered in the nucleolus by transcription and R-loops
Biomacromolecules
Exploring New Horizons in Liquid Compartmentalization via Microfluidics
Nucleic acids research
Suppression of liquid-liquid phase separation by 1,6-hexanediol partially compromises the 3D genome organization in living cells
Nature cell biology
The STING phase-separator suppresses innate immune signalling
Cell
Kinase-mediated RAS signaling via membraneless cytoplasmic protein granules
bioRxiv
Light-triggered and phosphorylation-dependent 14-3-3 association with NONPHOTOTROPIC HYPOCOTYL 3 is required for hypocotyl phototropism
bioRxiv
Condensation of pericentrin proteins in human cells illuminates phase separation in centrosome assembly
Neuron
Tau aggregates are RNA-protein assemblies that mislocalize multiple nuclear speckle components
International journal of biological macromolecules
Glass-like protein condensate for the long-term storage of proteins
Frontiers in cellular neuroscience
Hypothesis and Theory: Roles of Arginine Methylation in C9orf72-Mediated ALS and FTD
Journal of chemical theory and computation
Consistent Force Field Captures Homologue-Resolved HP1 Phase Separation
Proceedings of the National Academy of Sciences of the United States of America
Learning the molecular grammar of protein condensates from sequence determinants and embeddings
Protein science : a publication of the Protein Society
ATP energy-independently controls protein homeostasis with unique structure and diverse mechanisms
Jill Bouchard
Managing editor, Condensates.com
This review discusses the evolutionary implications of all of ATP's effects on phase separation and protein folding/stability.
JCI insight
Mitochondria-dependent phase separation of disease-relevant proteins drives pathological features of age-related macular degeneration
Methods (San Diego, Calif)
Integrating single-molecule spectroscopy and simulations for the study of intrinsically disordered proteins
Jill Bouchard
Managing editor, Condensates.com
This should be a nice breakdown of several methods that can be good for characterizing condensate-loving IDPs.
bioRxiv
Dipeptides are minimalistic but sufficient for liquid-liquid phase separation
Nature Cell Biology
Liquid-like protein assemblies initiate endocytosis
Jill Bouchard
Managing editor, Condensates.com
Here's the News & Views article associated with the latest Nature Cell Biol paper about liquid-like interactions and endocytic vesicles.