Oncogene
Decitabine suppresses triple-negative breast cancer by disrupting DNMT1 liquid-liquid phase separation and synergizes with G9a inhibition
Neurobiology of disease
Splicing modulation of ATXN2 as a therapeutic strategy to regulate Ataxin-2 protein levels in ALS
bioRxiv
Mimicking two posttranslational modifications associated with oxidative stress affords phase separation of vimentin
Cancer pathogenesis and therapy
From fusion partner to clinical practice: A treatment-oriented framework for transcription factor E3 (TFE3)-rearranged renal carcinoma
Bioactive materials
Biomimetic stress granules replenish lysosomal repair to reinstate macrophage immunometabolic antibacterial programs
Trends in molecular medicine
Statins suppress colon tumors by inhibiting KRAS condensates
Fish & shellfish immunology
A TFPI-1 Homolog from Sebastes schlegelii: Characterization of C-Terminal Endogenous Cleavage and Antimicrobial role of Derived Peptide
Cells
Initial Molecular Detection of Membrane Damage in Post-Golgi Compartments
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Ferroptosis Suppression by the M6A Reader IGF2BP1 Underlies Gemcitabine Resistance in Pancreatic Ductal Adenocarcinoma
Science advances
Capsid stabilization reprograms the nuclear fate of the HIV genome
Journal of colloid and interface science
Length-encoded phase transitions in proline-alanine-serine peptides: from nanoaggregates to condensates
Hepatology (Baltimore, Md.)
With no lysine kinase 1 in hepatic stellate cells promotes mouse and human liver fibrosis through glycolytic triosephosphate isomerase 1
Experimental cell research
From Contested Target to Context-Aware Node: A Three-Layer Regulatory Code for Interpreting FTO’s Oncogene-Tumor Suppressor Paradox in Cancer
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
SDF-1 Attenuates Oocyte Quality Decline During Reproductive Aging Through Autophagy-Enhanced Stress Granule Scavenging
Molecular and cellular biology
Global Profiling of Remodeled Subcellular Structures Due to Drug Treatment and Disease
bioRxiv : the preprint server for biology
Disrupting a Convergent Acetylation Circuit Collapses Leukemic Identity Across AML Subtypes
Small (Weinheim an der Bergstrasse, Germany)
Functionalized Coacervates for Cancer Therapy: Advances and Prospects in Phase-Separation-Based Intelligent Drug Delivery
Pathogens (Basel, Switzerland)
Hiding in Plain Sight: HIV-1 Membraneless Organelles as Nuclear Hubs-Host Hijacking, Replication, Immune Evasion, and Drug-Access Implications
Cells
Lipid Droplets as Metabolic-Epigenetic Signaling Hubs: Interplay Between Phase Separation, Cellular Adaptation, and Disease
Nucleic acids research