The authors looked into whether the arrangement of LLPS-promoting and solubilizing sequences in the genome lead to single genome packaging. Read on to learn about generalizable principles of virus compaction.

Pressure-Jump Kinetics of Liquid-Liquid Phase Separation: Comparison of Two Different Condensed Phases of the RNA-Binding Protein, Fused in Sarcoma

ATP biphasically modulates LLPS of TDP-43 PLD by specifically binding arginine residues

Tau protein liquid-liquid phase separation can initiate tau aggregation

Zn-dependent structural transition of SOD1 modulates its ability to undergo liquid-liquid phase separation

Electrostatically driven complex coacervation and amyloid aggregation of tau are independent processes with overlapping conditions

Is transcriptional regulation just going through a phase?

Molecular determinants for regulation of G3BP1/2 phase separation by the SARS-CoV-2 nucleocapsid protein

Phase separation of Epstein-Barr Virus EBNA2 and Its Coactivator EBNALP controls gene expression

Liquid-liquid phase separation of tau driven by hydrophobic interaction facilitates fibrillization of tau

Role of spatial patterning of N-protein interactions in SARS-CoV-2 genome packaging

Jill Bouchard

Senior Scientist – Neurological & Rare Diseases

Principal Scientist/Sr. Principal Scientist – Medicinal Chemistry

Senior Director, DMPK