RNA (New York, NY)
Most Recent
Cell
RNA promotes the formation of spatial compartments in the nucleus
The Plant journal : for cell and molecular biology
Phase separation of chromatin and small RNA pathways in plants
Nature
Nucleation landscape of biomolecular condensates
Neurology Genetics
Dysfunctional Homozygous VRK1-D263G Variant Impairs the Assembly of Cajal Bodies and DNA Damage Response in Hereditary Spastic Paraplegia
BioRxiv
RNA is required for the maintenance of multiple cytoplasmic and nuclear membrane-less organelles
bioRxiv
Coilin oligomerization and remodeling by Nopp140 reveals a hybrid assembly mechanism for Cajal bodies
Jill Bouchard
Managing editor, Condensates.com
Oligomerization and intrinsic disorder stake another claim to condensates.
Genes & development
Nopp140-chaperoned 2′-O-methylation of small nuclear RNAs in Cajal bodies ensures splicing fidelity
Jill Bouchard
Managing editor, Condensates.com
It looks like Cajal bodies play an important role in snRNA modification.
Frontiers in molecular biosciences
Post-Translational Modifications Modulate Proteinopathies of TDP-43, FUS and hnRNP-A/B in Amyotrophic Lateral Sclerosis
International journal of molecular sciences
Drosophila to Explore Nucleolar Stress
Jill Bouchard
Managing editor, Condensates.com
This paper delves into a whole lot of condensate crosstalk.
Cell reports
TOR signaling regulates liquid phase separation of the SMN complex governing snRNP biogenesis
Cell
DMA-tudor interaction modules control the specificity of in vivo condensates
Nucleic acids research
SANS (USH1G) regulates pre-mRNA splicing by mediating the intra-nuclear transfer of tri-snRNP complexes
Jill Bouchard
Managing editor, Condensates.com
This data led the authors to propose that SANS drives phase separation of nuclear speckles; I'm sure they're already working out the details.
Journal of cell science
The cajal body protein coilin is a regulator of the miR-210 hypoxamiR and influences MIR210HG alternative splicing
Jill Bouchard
Managing editor, Condensates.com
This work shows how Cajal bodies react to hypoxia. Check it out.
BioRxiv
TCAB1 is necessary for telomerase assembly
Jill Bouchard
Managing editor, Condensates.com
This is an interesting study about a protein that extracts components from the nucleolus so telomerase can assemble. I always love to hear when condensates play key roles in regulating important cellular functions.
Frontiers in cellular neuroscience
Altered Phase Separation and Cellular Impact in C9orf72-Linked ALS/FTD
Biochemical and biophysical research communications
G-patch domain-containing protein 4 localizes to both the nucleoli and Cajal bodies and regulates cell growth and nucleolar structure
Molecular Cell
Is transcriptional regulation just going through a phase?
International journal of molecular sciences
RNA-Binding Proteins and the Complex Pathophysiology of ALS
Jill Bouchard
Managing editor, Condensates.com
Here's a nice review about how mutations in RNA-binding proteins cause various membraneless organelles to dysfunction.
bioRxiv