Genes to cells : devoted to molecular & cellular mechanisms
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International journal of molecular sciences
Nuclear Reorganization in Hippocampal Granule Cell Neurons from a Mouse Model of Down Syndrome: Changes in Chromatin Configuration, Nucleoli and Cajal Bodies
Jill Bouchard
Contributing editor, Condensates.com
Here are some interesting effects of Down Syndrome on a couple condensates.
American Journal of Human Genetics
De novo TRIM8 variants impair its protein localization to nuclear bodies and cause developmental delay, epilepsy, and focal segmental glomerulosclerosis
bioRxiv
SANS (USH1G) regulates pre-mRNA splicing by mediating the intra-nuclear transfer of tri-snRNP complexes
Jill Bouchard
Contributing editor, Condensates.com
Here's a new protein associated with Cajal bodies and nuclear speckles.
bioRxiv
RNA polymerase II condensate formation and association with Cajal and histone locus bodies in living human cells
STAR protocols
Quantitative Imaging of MS2-Tagged hTR in Cajal Bodies: Photobleaching and Photoactivation
bioRxiv
SANS (USH1G) regulates pre-mRNA splicing by mediating the intra-nuclear transfer of tri-snRNPs from Cajal bodies to nuclear speckles for spliceosome assembly
Jill Bouchard
Contributing editor, Condensates.com
This paper implicates nuclear speckles and cajal bodies in the cellular dysfunctions that may lead to deaf-blindness.
Cell biochemistry and function
Novel nucleolar localization of clusterin and its associated functions in human oral cancers: An in vitro and in silico analysis
Jill Bouchard
Contributing editor, Condensates.com
This paper is about some complex communication between nucleoli and cajal bodies in cancer cells. Check it out to find out more.
PhD position in evaluation of liquid-liquid phase separation in disease cells and in vitro using fluorescence lifetime imaging and image correlation spectroscopy
The University of Manchester | Manchester, United Kingdom
ApplyeLife
A virus-encoded protein suppresses methylation of the viral genome through its interaction with AGO4 in the Cajal body
Developmental cell
Emerging Roles for Phase Separation in Plants
Biology open
Molecular determinants that govern scaRNA processing by Drosha/DGCR8
Jill Bouchard
Contributing editor, Condensates.com
Interesting, it looks like there may be some cross talk between Cajal bodies and nucleoli via scaRNAs.
Molecular & cellular oncology
A single-molecule view of telomerase regulation at telomeres
Jill Bouchard
Contributing editor, Condensates.com
Here's the author commentary about a recent study about the role of Cajal bodies in telomere regulation.
Proceedings of the National Academy of Sciences of the United States of America
A mouse tissue atlas of small noncoding RNA
Jill Bouchard
Contributing editor, Condensates.com
Here's a comprehensive analysis of condensate-specific noncoding RNAs from various tissues.
Viruses
Functional Characterization of Pepper Vein Banding Virus-Encoded Proteins and Their Interactions: Implications in Potyvirus Infection
Jill Bouchard
Contributing editor, Condensates.com
Here's an interesting review about how a plant virus uses its IDPs for multiple functions... including helping them localize to various membraneless organelles.
bioRxiv
DMA-tudor interaction modules control the specificity of in vivo condensates
Genes
The Impact of Coilin Nonsynonymous SNP Variants E121K and V145I on Cell Growth and Cajal Body Formation: The First Characterization
Jill Bouchard
Contributing editor, Condensates.com
This article is yet another example of how a single disease mutation in one protein can make a huge difference in the formation and function of a condensate.
Journal of visualized experiments : JoVE
Substructure Analyzer: A User-Friendly Workflow for Rapid Exploration and Accurate Analysis of Cellular Bodies in Fluorescence Microscopy Images
Jill Bouchard
Contributing editor, Condensates.com
This could be a really helpful method to monitor condensates.
Trends in biochemical sciences
Biomolecular Condensates in the Nucleus
Jill Bouchard
Contributing editor, Condensates.com
Need an update on what's new with nuclear condensates? This will be a good place to start!
BioMed research international
Rice stripe virus p2 Colocalizes and Interacts with Arabidopsis Cajal Bodies and Its Domains in Plant Cells
Jill Bouchard
Contributing editor, Condensates.com
Here's a plant virus that targets Cajal bodies in it's infection strategy.